Cx3cr1tm2.1(cre/ERT2)Litt
Targeted Allele Detail
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Symbol: |
Cx3cr1tm2.1(cre/ERT2)Litt |
Name: |
C-X3-C motif chemokine receptor 1; targeted mutation 2.1, Dan R Littman |
MGI ID: |
MGI:5450813 |
Synonyms: |
Cx3cr1CreER, CX3CR1YFP-creER |
Gene: |
Cx3cr1 Location: Chr9:119877749-119897362 bp, - strand Genetic Position: Chr9, 71.37 cM
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Alliance: |
Cx3cr1tm2.1(cre/ERT2)Litt page
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Germline Transmission: |
Earliest citation of germline transmission:
J:205483
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Parent Cell Line: |
E14.1 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Inducible, Recombinase, Reporter) |
Inducer: |
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tamoxifen |
Mutations: |
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Insertion, Intragenic deletion
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Cx3cr1tm2.1(cre/ERT2)Litt expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: A targeting vector was designed to replace exon 2 of the chemokine (C-X3-C) receptor 1 (Cx3cr1) gene with a cre/ERT2 (cre recombinase fused to an estrogen receptor ligand binding domain) coding sequence, followed by an internal ribosome entry site (IRES) and an enhanced yellow fluorescent protein (EYFP). A frt-flanked neomycin resistance cassette, in reverse orientation to the gene, was
also inserted downstream of the EYFP sequence. Flp-mediated recombination excised the neomycin resistance sequence.
(J:190965, J:205483)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Cx3cr1
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:190965 Littman DR, An inducible cre recombinase driven by Cx3cr1. MGI Direct Data Submission. 2013; |
All: |
211 reference(s) |
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