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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Dkk1
dickkopf WNT signaling pathway inhibitor 1
MGI:1329040
20 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Ctnnb1Bfc/\Ctnnb1+
\Dkk1tm1Lmgd/\Dkk1+
either: (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl) or (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl * C57BL/6) 		abnormal eye morphology J:170646
abnormal head morphology J:170646
preweaning lethality, incomplete penetrance J:170646
\Ctnnb1Bfc/\Ctnnb1+
\Dkk1tm1Lmgd/\Dkk1+
\Lrp6Gw/\Lrp6+
either: (involves: 101/H * 129 * BALB/cCrl * C3H) or (involves: 101/H * 129 * BALB/cCrl * C3H * C57BL/6) 		abnormal head size J:170646
caudal body truncation J:170646
\Ctnnb1Bfc/\Ctnnb1Bfc
\Dkk1tm1Lmgd/\Dkk1+
either: (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl) or (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl * C57BL/6) 		abnormal head size J:170646
\Dkk1tm1Lmgd/\Dkk1+
\Lrp6Gw/\Lrp6+
involves: 101/H * 129 * BALB/c * C3H 		abnormal head morphology J:170646
kinked tail J:170646
\Dkk1tm1Lmgd/\Dkk1+
\Lrp6Gw/\Lrp6Gw
involves: 101/H * 129 * BALB/c * C3H 		abnormal head morphology J:170646
\Dkk1tm1Lmgd/\Dkk1+
\Gsctm2Bhr/\Gsc+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		decreased forebrain size J:119933
\Dkk1tm1Lmgd/\Dkk1+
\Gsctm2Bhr/\Gsctm2Bhr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal embryo development J:119933
abnormal eye development J:119933
decreased forebrain size J:119933
microcephaly J:119933
\Dkk1tm1Lmgd/\Dkk1+
\Kremen1tm1Dgen/\Kremen1tm1Dgen
\Kremen2tm1Cni/\Kremen2tm1Cni
either: B6.Cg-Kremen1tm1Dgen Kremen2tm1Cni Dkk1tm1Lmgd or (involves: 129S1/Sv * 129X1/SvJ * CD-1) 		increased bone volume J:137914
polydactyly J:137914
\Dkk1tm1Lmgd/\Dkk1tm1Lmgd
\Sfrp5tm1Shwl/\Sfrp5tm1Shwl
involves: 129 * CD-1 		abnormal anterior head development J:117057
normal embryo phenotype J:117057
perinatal lethality, complete penetrance J:117057
\Dkk1tm1Sia/\Dkk1tm1Sia
\Sfrp1tm1Aksh/\Sfrp1tm1Aksh
involves: 129 * C57BL/6 * CBA 		incomplete somite formation J:135313
\Dkk1tm1Sia/\Dkk1tm1Sia
\Sfrp1tm1Aksh/\Sfrp1tm1Aksh
\Sfrp2tm1Aksh/\Sfrp2+
involves: 129 * C57BL/6 * CBA 		incomplete somite formation J:135313
\Dkk1tm1Sia/\Dkk1tm1Sia
\Sfrp1tm1Aksh/\Sfrp1tm1Aksh
\Sfrp2tm1Aksh/\Sfrp2tm1Aksh
involves: 129 * C57BL/6 * CBA 		abnormal presomitic mesoderm morphology J:135313
incomplete embryo turning J:135313
incomplete somite formation J:135313
\Gt(ROSA)26Sortm1(Dkk1)Flng/\Gt(ROSA)26Sor+
\Rac1tm1Djk/\Rac1+
\Tg(Msx2-cre)5Rem/0
involves: 129S4/SvJae * 129X1/SvJ 		absent hindlimb J:145305
short forelimb J:145305
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory