126 phenotypes from 4 alleles in 20 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Atg5em1Smoc/Atg5em1Smoc S100a4em1(cre)Zhyg/S100a4+ involves: C57BL/6J	abnormal tumor morphology	J:330821
	decreased tumor growth/size	J:330821
Atg5Gt(IRESBetageo)4Pgr/Atg5Gt(IRESBetageo)4Pgr involves: 129S1/Sv * 129X1/SvJ * NMRI	no abnormal phenotype detected	J:48376
Atg5tm1Myok/Atg5tm1Myok involves: 129S/SvEv	normal cellular phenotype	J:232686
Atg5tm1Myok/Atg5tm1Myok involves: 129S/SvEv * C57BL/6	no abnormal phenotype detected	J:110050
Atg5tm1Myok/Atg5tm1Myok A1cfTg(Myh6-cre/Esr1*)1Jmk/? involves: 129S/SvEv * FVB/N	abnormal cardiac muscle contractility	J:121778
	abnormal myocardial fiber physiology	J:121778
	dilated heart left ventricle	J:121778
	increased heart weight	J:121778
	increased lung weight	J:121778
	increased myocardial fiber size	J:121778
Atg5tm1Myok/Atg5tm1Myok Lyz2tm1(cre)Ifo/Lyz2+ involves: 129P2/OlaHsd * 129S/SvEv	abnormal circulating chemokine level	J:235399
	abnormal kidney morphology	J:235399
	abnormal macrophage physiology	J:235399
	abnormal renal glomerulus morphology	J:235399
	decreased body weight	J:235399
	decreased circulating interleukin-10 level	J:235399
	glomerulonephritis	J:235399
	increased anti-double stranded DNA antibody level	J:235399
	increased anti-nuclear antigen antibody level	J:235399
	increased autoantibody level	J:235399
	increased blood urea nitrogen level	J:235399
	increased circulating creatinine level	J:235399
	increased circulating interleukin-1 beta level	J:235399
	increased circulating interleukin-6 level	J:235399
	increased circulating interleukin-12b level	J:235399
	increased IgG level	J:235399
	increased lymphocyte cell number	J:235399
	increased monocyte cell number	J:235399
	increased neutrophil cell number	J:235399
	increased susceptibility to systemic lupus erythematosus	J:235399
	increased urine protein level	J:235399
Atg5tm1Myok/Atg5tm1Myok Myl2tm1(cre)Krc/Myl2+ involves: 129S/SvEv * 129S4/SvJae	abnormal cardiovascular system physiology	J:121778
	congestive heart failure	J:121778
	dilated heart left ventricle	J:121778
	increased physiological sensitivity to xenobiotic	J:121778
	increased susceptibility to induced morbidity/mortality	J:121778
Atg5tm1Myok/Atg5tm1Myok Tg(BEST1-cre)1Taf/0 involves: 129S/SvEv * C57BL/6J	abnormal autophagy	J:200084
	decreased a-wave amplitude	J:200084
	decreased b-wave amplitude	J:200084
	normal vision/eye phenotype	J:200084
Atg5tm1Myok/Atg5tm1Myok Tg(CAG-cre)13Miya/? involves: 129S/SvEv * C57BL/6	abnormal liver morphology	J:110050
Atg5tm1Myok/Atg5tm1Myok Tg(Kap-cre)1Isa/0 involves: 129S/SvEv * C57BL/6 * DBA	abnormal proximal convoluted tubule morphology	J:179961
	aminoaciduria	J:179961
	normal homeostasis/metabolism phenotype	J:179961
	hyperthreoninuria	J:179961
	impaired autophagy	J:179961
	increased kidney weight	J:179961
	increased urine glucose level	J:179961
	normal mortality/aging	J:179961
	tryptophanuria	J:179961
	valinuria	J:179961
Atg5tm1Myok/Atg5tm1Myok Tg(Kap-icre)29066/2Sig/0 involves: 129S/SvEv * C57BL/6J * SJL	increased susceptibility to induced morbidity/mortality	J:293453
Atg5tm1Myok/Atg5tm1Myok Tg(Mx1-cre)1Cgn/? involves: 129S/SvEv * C57BL/6 * CBA	abnormal liver morphology	J:110050
Atg5tm1Myok/Atg5tm1Myok Tg(Myh6-cre)2182Mds/? involves: 129S/SvEv * C57BL/6 * FVB/N	no abnormal phenotype detected	J:121778
Atg5tm1Myok/Atg5tm1Myok Tg(Nes-cre)1Kln/? involves: 129S/SvEv * C57BL/6 * SJL	abnormal axon morphology	J:110050
	abnormal behavior	J:110050
	abnormal brain morphology	J:110050
	abnormal cell physiology	J:110050
	abnormal cerebellar granule cell morphology	J:110050
	abnormal cerebral cortex morphology	J:110050
	abnormal hippocampus morphology	J:110050
	abnormal inferior colliculus morphology	J:110050
	abnormal motor capabilities/coordination/movement	J:110050
	abnormal suckling behavior	J:110050
	abnormal thalamus morphology	J:110050
	ataxia	J:110050
	decreased body weight	J:110050
	decreased cerebral cortex pyramidal cell number	J:110050
	decreased grip strength	J:110050
	impaired coordination	J:110050
	limb grasping	J:110050
	neuron degeneration	J:110050
	neuronal intranuclear inclusions	J:110050
	postnatal growth retardation	J:110050
	premature death	J:110050
	Purkinje cell degeneration	J:110050
	short stride length	J:110050
	tremors	J:110050
Atg5tm1Myok/Atg5tm1Myok Tg(Pomc1-cre)1Gsb/0 involves: 129S/SvEv * C57BL/6 * FVB/N	abnormal autophagy	J:232686
	normal adipose tissue phenotype	J:232686
	normal growth/size/body region phenotype	J:232686
	normal nervous system phenotype	J:232686
Atg5tm1Myok/Atg5tm1Myok Tg(SFTPC-cre)11Yo/0 involves: 129S/SvEv * C57BL/6	normal mortality/aging	J:300057
Atg5tm1Myok/Atg5tm1Myok Tg(Stra8-icre)1Reb/0 involves: 129S/SvEv * FVB/NJ	abnormal acrosome assembly	J:307712
	abnormal cauda epididymis morphology	J:307712
	abnormal sperm end piece morphology	J:307712
	abnormal sperm flagellum morphology	J:307712
	abnormal sperm head morphology	J:307712
	abnormal sperm individualization	J:307712
	abnormal sperm midpiece morphology	J:307712
	abnormal sperm mitochondrial sheath morphology	J:307712
	abnormal sperm nucleus morphology	J:307712
	abnormal spermiation	J:307712
	abnormal spermiogenesis	J:307712
	abnormal testis physiology	J:307712
	absent sperm fibrous sheath	J:307712
	asthenozoospermia	J:307712
	decreased testis weight	J:307712
	double-headed sperm	J:307712
	globozoospermia	J:307712
	immotile sperm	J:307712
	impaired autophagy	J:307712
	male infertility	J:307712
	multinucleated giant male germ cells	J:307712
	oligozoospermia	J:307712
	reduced male fertility	J:307712
	short sperm flagellum	J:307712
	teratozoospermia	J:307712
Atg5tm1Myok/Atg5tm1Myok Tg(Vil1-cre)997Gum/0 involves: 129S/SvEv * C57BL/6 * SJL	abnormal Paneth cell morphology	J:141419
	impaired autophagy	J:141419
Atg5tm1Myok/Atg5tm1Myok Tg(Vil1-cre)1000Gum/0 involves: 129S/SvEv * C57BL/6J * SJL/J	abnormal intestinal goblet cell morphology	J:206181
Atg5tm1Nmz/Atg5tm1Nmz B6.129-Atg5tm1Nmz/NmzRbrc	normal respiratory system phenotype	J:300057
Atg5tm1Nmz/Atg5tm1Nmz involves: 129 * BALB/c * C57BL/6	abnormal thymus cortex morphology	J:140583
Atg5tm1Nmz/Atg5tm1Nmz involves: 129S1/Sv * 129X1/SvJ	abnormal adenohypophysis morphology	J:110050
	abnormal adrenal gland morphology	J:110050
	abnormal brain morphology	J:110050
	abnormal hepatocyte morphology	J:110050
	abnormal liver morphology	J:110050
	abnormal utricle morphology	J:163712
	absent otoliths	J:163712
	enlarged otoliths	J:163712
	neuronal intranuclear inclusions	J:110050
Atg5tm1Nmz/Atg5tm1Nmz involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal amino acid level	J:104491
	abnormal circulating amino acid level	J:104491
	abnormal lysosome morphology	J:104491
	abnormal ST segment	J:104491
	absent gastric milk in neonates	J:104491
	normal hematopoietic system phenotype	J:103983
	neonatal lethality, complete penetrance	J:104491
	normal vision/eye phenotype	J:103983
Atg5tm1Nmz/Atg5tm1Nmz Tg(Cd4-cre)1Cwi/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	abnormal T cell morphology	J:211733
	abnormal T cell physiology	J:211733
	abnormal T cell subpopulation ratio	J:211733
	decreased CD4-positive, alpha-beta T cell number	J:211733
	decreased CD8-positive, alpha-beta T cell number	J:211733
	decreased T cell number	J:211733
	decreased T cell proliferation	J:211733
	impaired autophagy	J:211733
	increased mitochondrial size	J:211733
	oxidative stress	J:211733