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Targeted Allele Detail
Symbol: Atg5tm1Myok
Name: autophagy related 5; targeted mutation 1, Minesuke Yokoyama
MGI ID: MGI:3663625
Synonyms: atg5f, Atg5flox
Gene: Atg5  Location: Chr10:44144354-44240287 bp, + strand  Genetic Position: Chr10, 23.24 cM
Alliance: Atg5tm1Myok page
Cataract development in Atg5tm1Myok/Atg5tm1Myok Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Cryaa-cre)10Mlr/0 mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:110050
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to flank exon 3 with loxP sites. A neomycin resistance cassette was included such that expression of cre recombinase would remove both exon 3 and the neo. (J:110050)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 22 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Atg5tm1Myok
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Atg5 Mutation:  26 strains or lines available
Original:  J:110050 Hara T, et al., Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature. 2006 Jun 15;441(7095):885-9
All:  241 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory