Gfi1b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gfi1b
growth factor independent 1B
MGI:1276578

31 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Col1a1^{tm1(tetO-cre)Haho}/? Gfi1b^tm1.1Haho/Gfi1b^tm1.1Haho involves: 129S4/SvJaeSor * C57BL/6	abnormal megakaryocyte differentiation	J:207446
	abnormal megakaryocyte progenitor cell morphology	J:207446
	absent erythroid progenitor cell	J:207446
	absent platelets	J:207446
	anemia	J:207446
	decreased hemoglobin content	J:207446
	postnatal lethality, complete penetrance	J:207446
	thrombocytopenia	J:207446
Gfi1b^tm1.1Haho/Gfi1b^tm1.1Haho Tg(Mx1-cre)1Cgn/0 involves: 129S4/SvJaeSor * C57BL/6	abnormal bone marrow cell morphology/development	J:207446
	abnormal megakaryocyte differentiation	J:207446
	abnormal megakaryocyte progenitor cell morphology	J:207446
	absent erythroid progenitor cell	J:207446
	absent platelets	J:207446
	anemia	J:207446
	decreased hemoglobin content	J:207446
	postnatal lethality, complete penetrance	J:207446
	thrombocytopenia	J:207446
Gfi1b^{tm1b(EUCOMM)Hmgu}/Gfi1b⁺ C57BL/6N-Gfi1b^{tm1b(EUCOMM)Hmgu}/H	decreased neutrophil cell number	J:211773
	increased circulating bilirubin level	J:211773
	increased circulating serum albumin level	J:211773
	increased lymphocyte cell number	J:211773
	increased total body fat amount	J:211773
Gfi1b^{tm1b(EUCOMM)Hmgu}/Gfi1b^{tm1b(EUCOMM)Hmgu} C57BL/6N-Gfi1b^{tm1b(EUCOMM)Hmgu}/H	prenatal lethality	J:211773
	preweaning lethality, complete penetrance	J:211773
Gfi1b^tm1Sho/Gfi1b^tm1Sho involves: 129S1/Sv	abnormal embryonic erythrocyte morphology	J:74523
	abnormal embryonic erythropoiesis	J:74523
	abnormal erythropoiesis	J:74523
	abnormal megakaryocyte differentiation	J:74523
	absent erythrocytes	J:74523
	edema	J:74523
	hemorrhage	J:74523
	lethality throughout fetal growth and development, complete penetrance	J:74523
	pallor	J:74523
Gfi1b^tm1Tmo/Gfi1b^tm1Tmo B6.129-Gfi1b^tm1Tmo	abnormal erythropoiesis	J:141749
	internal hemorrhage	J:141749
	lethality throughout fetal growth and development, complete penetrance	J:141749
Gfi1b^tm2Tmo/Gfi1b^tm2Tmo Tg(Mx1-cre)1Cgn/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	abnormal blood cell morphology/development	J:167416
	abnormal hematopoietic stem cell physiology	J:167416
	decreased erythrocyte cell number	J:167416
	normal hematopoietic system phenotype	J:167416
	increased hematopoietic stem cell number	J:167416
	increased splenocyte number	J:167416
	thrombocytopenia	J:167416

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