Gfi1b^tm2Tmo
Targeted Allele Detail

Summary

• Symbol: Gfi1b^tm2Tmo
• Name: growth factor independent 1B; targeted mutation 2, Tarik Moroy
• MGI ID: MGI:4868580
• Gene: Gfi1b Location: Chr2:28499462-28511994 bp, - strand Genetic Position: Chr2, 19.38 cM
• Alliance: Gfi1b^tm2Tmo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167416
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT flanked neomycin selection cassette was inserted in intron 4. Exons 2-4 and the selection cassette were flanked by loxP sites. (J:167416)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gfi1b Mutation: 20 strains or lines available

References

• Original: J:167416 Khandanpour C, et al., Evidence that growth factor independence 1b regulates dormancy and peripheral blood mobilization of hematopoietic stem cells. Blood. 2010 Dec 9;116(24):5149-61
• All: 5 reference(s)