Nus1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nus1
NUS1 dehydrodolichyl diphosphate synthase subunit
MGI:1196365

32 phenotypes from 4 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj} Nus1^tm1.1Qrm/Nus1^tm1.1Qrm involves: 129 * C57BL/6 * SJL	abnormal lipid homeostasis	J:243753
	hepatic steatosis	J:243753
	increased liver free fatty acids level	J:243753
	increased liver triglyceride level	J:243753
Nus1^tm1.1Qrm/Nus1^tm1.1Qrm Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129 * C57BL/6 * DBA * SJL	abnormal circulating cholesterol level	J:243753
	abnormal lipid homeostasis	J:243753
	decreased liver cholesterol level	J:243753
	increased circulating free fatty acids level	J:243753
	increased circulating triglyceride level	J:243753
	increased liver free fatty acids level	J:243753
	increased liver triglyceride level	J:243753
Nus1^tm1.1Qrm/Nus1^tm1.1Qrm Tg(Cdh5-cre/ERT2)1Rha/0 involves: 129P2/OlaHsd * C57BL/6	abnormal brain vasculature morphology	J:229464
	abnormal vascular development	J:229464
	decreased embryo size	J:229464
Nus1^tm1.1Qrm/Nus1^tm1.1Qrm Tg(Tek-cre)1Ywa/0 involves: 129P2/OlaHsd * C57BL/6 * SJL	abnormal brain vasculature morphology	J:229464
	abnormal vascular development	J:229464
	abnormal vitelline vasculature morphology	J:229464
	decreased embryo size	J:229464
	embryonic lethality during organogenesis, complete penetrance	J:229464
Nus1^tm1.1Wcsa/Nus1^tm1.1Wcsa involves: 129S4/SvJae	embryonic lethality, complete penetrance	J:215785
Nus1^tm1.2Qrm/Nus1⁺ involves: 129P2/OlaHsd * FVB/N	abnormal vascular development	J:229464
Nus1^tm1.2Qrm/Nus1^tm1.2Qrm involves: 129P2/OlaHsd * FVB/N	embryonic lethality between implantation and somite formation, complete penetrance	J:229464
Nus1^tm1Wcsa/Nus1^tm1.1Wcsa involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	abnormal cell physiology	J:215785
	abnormal cellular cholesterol metabolism	J:215785
	increased sensitivity to induced cell death	J:215785
Nus1^tm1Wcsa/Nus1^tm1Wcsa Not Specified	abnormal lung endothelial cell physiology	J:230506
	decreased lung endothelial cell proliferation	J:230506
	increased lung endothelial cell apoptosis	J:230506
Nus1^tm1Wcsa/Nus1^tm1Wcsa Tg(Cdh5-cre/ERT2)1Rha/0 Not Specified	abnormal jugular lymph sac morphology	J:230506
	abnormal vascular development	J:230506
	abnormal vitelline vasculature morphology	J:230506
	decreased endothelial cell proliferation	J:230506
	embryonic lethality, complete penetrance	J:230506
	hemorrhage	J:230506
	increased vascular endothelial cell apoptosis	J:230506
	subcutaneous edema	J:230506
Nus1^tm1Wcsa/Nus1^tm1Wcsa Tg(Tek-cre)12Flv/0 involves: C3H * C57BL/6	abnormal embryo morphology	J:230506
	abnormal placenta vasculature	J:230506
	abnormal vascular endothelial cell physiology	J:230506
	abnormal visceral yolk sac physiology	J:230506
	abnormal vitelline vasculature morphology	J:230506
	decreased embryo size	J:230506
	embryonic lethality during organogenesis, complete penetrance	J:230506
	excessive folding of visceral yolk sac	J:230506
	thin placenta labyrinth	J:230506

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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