Nus1^tm1.2Qrm
Targeted Allele Detail

Summary

• Symbol: Nus1^tm1.2Qrm
• Name: NUS1 dehydrodolichyl diphosphate synthase subunit; targeted mutation 1.2, Qing Robert Miao
• MGI ID: MGI:6361026
• Synonyms: NgBR^KO, Nus1^ko
• Gene: Nus1 Location: Chr10:52293643-52316279 bp, + strand Genetic Position: Chr10, 26.64 cM
• Alliance: Nus1^tm1.2Qrm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229464
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and a loxP site and FRT-flanked neo cassette were inserted downstream of exon 4 via homologous recombination. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination in the germline removed exons 2-4. (J:229464)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nus1 Mutation: 18 strains or lines available

References

• Original: J:229464 Rana U, et al., Nogo-B receptor deficiency causes cerebral vasculature defects during embryonic development in mice. Dev Biol. 2016 Feb 15;410(2):190-201
• All: 1 reference(s)