About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nus1tm1.2Qrm
targeted mutation 1.2, Qing Robert Miao
MGI:6361026
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nus1tm1.2Qrm/Nus1tm1.2Qrm involves: 129P2/OlaHsd * FVB/N MGI:6361027
ht2
 		Nus1tm1.2Qrm/Nus1+ involves: 129P2/OlaHsd * FVB/N MGI:6361028


Genotype
MGI:6361027
hm1
Allelic
Composition		 Nus1tm1.2Qrm/Nus1tm1.2Qrm
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nus1tm1.2Qrm mutation (0 available); any Nus1 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:229464 )
• early embryonic lethality with no embryos seen at E7.5




Genotype
MGI:6361028
ht2
Allelic
Composition		 Nus1tm1.2Qrm/Nus1+
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nus1tm1.2Qrm mutation (0 available); any Nus1 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal vascular development ( J:229464 )
• embryoid bodies derived from embryonic stem cells exhibit defective blood vessel development, form dilated and truncated EC tubes which have less branching and fail to develop into a tree-like structure in vitro
• however, heterozygous mice are viable




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory