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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Kdm1a
lysine (K)-specific demethylase 1A
MGI:1196256
80 phenotypes from 9 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Gt(ROSA)26Sortm2(H1/tetO-RNAi:Kdm1a)Arte/Gt(ROSA)26Sor+
involves: C57BL/6
abnormal bone marrow cell morphology/development J:192055
abnormal erythropoiesis J:192055
abnormal granulocyte differentiation J:192055
abnormal megakaryocyte morphology J:192055
abnormal megakaryocyte progenitor cell morphology J:192055
abnormal monocyte differentiation J:192055
abnormal platelet morphology J:192055
abnormal proerythroblast morphology J:192055
anemia J:192055
decreased erythroid progenitor cell number J:192055
enlarged spleen J:192055
normal hematopoietic system phenotype J:192055
increased circulating erythropoietin level J:192055
increased erythroid progenitor cell number J:192055
increased hematopoietic stem cell number J:192055
increased hematopoietic stem cell proliferation J:192055
increased leukocyte cell number J:192055
increased mean platelet volume J:192055
increased megakaryocyte cell number J:192055
Kdm1aGt(RRK075)Byg/Kdm1aGt(RRK075)Byg
involves: 129P2/OlaHsd * C57BL/6
abnormal gastrulation J:169674
embryonic lethality between implantation and placentation, incomplete penetrance J:169674
embryonic lethality during organogenesis, complete penetrance J:169674
Kdm1aGt(RRK075)Byg/Kdm1atm1.2Rsd
involves: 129P2/OlaHsd * C57BL/6
abnormal gastrulation J:169674
prenatal lethality, complete penetrance J:169674
Kdm1atm1(NCOM)Mfgc/Kdm1a+
C57BL/6N-Kdm1atm1(NCOM)Mfgc/Nju
decreased grip strength J:211773
decreased locomotor activity J:211773
increased basophil cell number J:211773
increased eosinophil cell number J:211773
increased mean platelet volume J:211773
small heart J:211773
small kidney J:211773
small liver J:211773
small lung J:211773
small spleen J:211773
Kdm1atm1(NCOM)Mfgc/Kdm1atm1(NCOM)Mfgc
C57BL/6N-Kdm1atm1(NCOM)Mfgc/Nju
preweaning lethality, complete penetrance J:211773
Kdm1atm1.1Rsd/Kdm1atm1.1Rsd
Tg(Pitx1-cre)7Rsd/0
involves: BALB/c * C57BL/6
abnormal cell cycle J:121427
abnormal luteinizing hormone level J:121427
abnormal pituitary gland development J:121427
abnormal pituitary hormone level J:121427
decreased growth hormone level J:121427
decreased thyroid-stimulating hormone level J:121427
normal nervous system phenotype J:121427
Kdm1atm1.1Sbae/Kdm1atm1.1Sbae
B6.Cg-Kdm1atm1.1Sbae
abnormal circadian behavior persistence J:210640
abnormal circardian behavior entrainment J:210640
normal behavior/neurological phenotype J:210640
Kdm1atm1.1Sho/Kdm1atm1.1Sho
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
abnormal definitive hematopoiesis J:201572
decreased body size J:201572
decreased bone marrow cell number J:201572
decreased common myeloid progenitor cell number J:201572
decreased erythrocyte cell number J:201572
decreased hematopoietic stem cell number J:201572
decreased leukocyte cell number J:201572
postnatal lethality, incomplete penetrance J:201572
thrombocytopenia J:201572
Kdm1atm1.1Sho/Kdm1atm1.1Sho
Eportm1.1(EGFP/icre)Uk/Epor+
involves: 129 * BALB/cJ
abnormal erythropoiesis J:201572
abnormal liver morphology J:201572
abnormal proerythroblast morphology J:201572
decreased embryo size J:201572
decreased fetal derived definitive erythrocyte cell number J:201572
pale liver J:201572
reticulocytopenia J:201572
Kdm1atm1.1Sho/Kdm1atm1.1Sho
Tg(Mx1-cre)1Cgn/?
involves: 129 * C57BL/6 * CBA/Ca
abnormal common myeloid progenitor cell morphology J:201572
abnormal definitive hematopoiesis J:201572
abnormal induced morbidity/mortality J:201572
decreased common myeloid progenitor cell number J:201572
decreased granulocyte number J:201572
decreased hematopoietic stem cell number J:201572
decreased neutrophil cell number J:201572
increased hematopoietic stem cell number J:201572
pancytopenia J:201572
Kdm1atm1.1Tche/Kdm1atm1.1Tche
Not Specified
abnormal heart development J:270116
abnormal mitral valve morphology J:270116
cardiac muscle degeneration J:270116
lethality during fetal growth through weaning, complete penetrance J:270116
perimembraneous ventricular septal defect J:270116
perinatal lethality, complete penetrance J:270116
Kdm1atm1.1Tche/Kdm1atm1.2Tche
Not Specified
ventricular septal defect J:270116
Kdm1atm1.2Rsd/Kdm1atm1.2Rsd
Not Specified
abnormal gastrulation J:169674
embryonic lethality between implantation and somite formation, complete penetrance J:121427
lethality during fetal growth through weaning, complete penetrance J:169674
Kdm1atm1.2Tche/Kdm1a+
involves: 129 * C57BL/6
no abnormal phenotype detected J:144527
Kdm1atm1.2Tche/Kdm1atm1.2Tche
involves: 129 * C57BL/6
absent egg cylinders J:144527
embryonic growth arrest J:144527
embryonic lethality between implantation and somite formation, complete penetrance J:144527
failure to gastrulate J:144527
increased apoptosis J:144527
Kdm1atm1Ebg/Kdm1atm1Ebg
B6.129-Kdm1atm1Ebg
abnormal brain wave pattern J:235553
absence seizures J:235553
decreased susceptibility to pharmacologically induced seizures J:235553
decreased susceptibility to xenobiotic induced morbidity/mortality J:235553
normal nervous system phenotype J:235553
tonic-clonic seizures J:235553

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory