Kdm1a^tm1.2Rsd
Targeted Allele Detail

Summary

• Symbol: Kdm1a^tm1.2Rsd
• Name: lysine (K)-specific demethylase 1A; targeted mutation 1.2, Michael G Rosenfeld
• MGI ID: MGI:3711561
• Synonyms: Lsd1^-
• Gene: Kdm1a Location: Chr4:136277851-136330034 bp, - strand Genetic Position: Chr4, 68.8 cM
• Alliance: Kdm1a^tm1.2Rsd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121427
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector was used to insert loxP sites to flank an HSVTK-PGKNeo cassette and exon 6, which corresponds to the amino terminus of the amine oxidase domain. A type I recombination event in ES cells resulted in deletion of the selection cassette and exon6, leaving a single loxP site. (J:121427)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm1a Mutation: 42 strains or lines available

References

• Original: J:121427 Wang J, et al., Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature. 2007 Apr 19;446(7138):882-7
• All: 4 reference(s)