Fzd4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Fzd4
frizzled class receptor 4
MGI:108520

54 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Fzd4^{tm1.1(KOMP)Vlcg}/Fzd4^{tm1.1(KOMP)Vlcg} C57BL/6N-Fzd4^{tm1.1(KOMP)Vlcg}/Ucd	edema	J:211773
Fzd4^tm1.1Lex/Fzd4^tm1.1Lex involves: 129S5/SvEvBrd * C57BL/6	normal cardiovascular system phenotype	J:181399
	decreased angiogenesis	J:181399
Fzd4^tm1Nat/Fzd4^tm1Nat involves: 129S1/Sv * 129X1/SvJ	abnormal brain vasculature morphology	J:154020
	abnormal cerebellum morphology	J:154020
	abnormal eye electrophysiology	J:154020
	abnormal optokinetic reflex	J:154020
	abnormal retina vasculature morphology	J:154020
	impaired pupillary reflex	J:154020
	small kidney	J:170839
Fzd4^tm1Nat/Fzd4^tm1Nat involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal astrocyte physiology	J:70078
	abnormal cerebellar granule layer morphology	J:70078
	abnormal cerebellum morphology	J:107732
	abnormal corpus luteum morphology	J:115734
	abnormal digestion	J:70078
	abnormal esophageal squamous epithelium morphology	J:70078
	abnormal esophagus morphology	J:70078
	abnormal gait	J:70078
	abnormal organ of Corti morphology	J:107732
	abnormal posture	J:70078
	abnormal retina development	J:328283
	abnormal retina vasculature morphology	J:107732
	abnormal stria vascularis morphology	J:107732
	abnormal stria vascularis vasculature morphology	J:107732
	abnormal vascular development	J:115734
	absent corpus luteum	J:115734
	absent startle reflex	J:70078
	ataxia	J:70078
	cerebellum hypoplasia	J:70078
	cochlear hair cell degeneration	J:107732
	cochlear inner hair cell degeneration	J:107732
	cochlear outer hair cell degeneration	J:107732
	decreased angiogenesis	J:328283
	decreased circulating progesterone level	J:115734
	decreased Purkinje cell number	J:70078
	decreased skeletal muscle fiber diameter	J:70078
	decreased startle reflex	J:70078
	diluted coat color	J:70078
	enlarged esophagus	J:70078
	failure of embryo implantation	J:115734
	female infertility	J:115734
	hemorrhage	J:107732, J:328283
	hunched posture	J:70078
	impaired hearing	J:70078
	impaired luteal cell differentiation	J:115734
	impaired luteinization	J:115734
	increased or absent threshold for auditory brainstem response	J:70078
	male infertility	J:115734
	persistence of hyaloid vascular system	J:107732
	premature death	J:70078
	normal reproductive system phenotype	J:115734
	retina hemorrhage	J:107732
	short stride length	J:70078
	stria vascularis degeneration	J:107732
	weight loss	J:70078
Fzd4^tm1Nat/Fzd4^tm2.1Nat Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ involves: 129S1/Sv * 129X1/SvJ	small kidney	J:170839
Fzd4^tm1Nat/Fzd4^tm2.1Nat Tg(rx3-icre)1Mjam/? involves: 129S1/Sv * 129X1/SvJ	abnormal eye electrophysiology	J:154020
Fzd4^tm1Nat/Fzd4^tm2.1Nat Tg(Tek-cre)1Ywa/0 involves: 129S1/Sv * 129X1/SvJ	normal renal/urinary system phenotype	J:170839
Fzd4^tm1Nat/Fzd4^tm2.1Nat Tg(Tek-cre)1Ywa/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	abnormal brain vasculature morphology	J:154020
	abnormal eye electrophysiology	J:154020
	abnormal optokinetic reflex	J:154020
	abnormal retina vasculature morphology	J:154020
	impaired pupillary reflex	J:154020
Fzd4^tm2.1Nat/Fzd4^tm2.1Nat involves: 129S1/Sv * 129X1/SvJ	no abnormal phenotype detected	J:154020

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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