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Fzd4 Gene Detail
Summary
  • Symbol
    Fzd4
  • Name
    frizzled class receptor 4
  • Synonyms
    Fz4
  • Feature Type
    protein coding gene
  • IDs
    MGI:108520
    NCBI Gene: 14366
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:89053574-89062341 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 49.32 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    199 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108520
protein coding gene Chr7:89053563-89062342 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032495
protein coding gene Chr7:91814340-91820085 (+)
A/J MGP_AJ_G0032469
protein coding gene Chr7:89621401-89627142 (+)
AKR/J MGP_AKRJ_G0032405
protein coding gene Chr7:91697795-91703535 (+)
BALB/cJ MGP_BALBcJ_G0032480
protein coding gene Chr7:89267136-89272877 (+)
C3H/HeJ MGP_C3HHeJ_G0032195
protein coding gene Chr7:92102746-92108491 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032978
protein coding gene Chr7:95369628-95375372 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029973
protein coding gene Chr7:92537900-92543623 (+)
CAST/EiJ MGP_CASTEiJ_G0031522
protein coding gene Chr7:83537958-83543699 (+)
CBA/J MGP_CBAJ_G0032162
protein coding gene Chr7:98557863-98563608 (+)
DBA/2J MGP_DBA2J_G0032314
protein coding gene Chr7:88051618-88057363 (+)
FVB/NJ MGP_FVBNJ_G0032270
protein coding gene Chr7:87924691-87930430 (+)
LP/J MGP_LPJ_G0032403
protein coding gene Chr7:93049548-93055292 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032304
protein coding gene Chr7:99611610-99617350 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033000
protein coding gene Chr7:90994343-91000088 (+)
PWK/PhJ MGP_PWKPhJ_G0031240
protein coding gene Chr7:81067377-81073147 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031083
protein coding gene Chr7:78311042-78367431 (+)
WSB/EiJ MGP_WSBEiJ_G0031639
protein coding gene Chr7:91607248-91612992 (+)



Homology
more
  • Human Ortholog
    FZD4, frizzled class receptor 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FZD4, frizzled class receptor 4
  • Synonyms
    CD344, EVR1, FEVR, Fz-4, Fz4, FZD4S, FzE4, GPCR, hFz4
  • Links
    NCBI Gene ID: 8322
    neXtProt AC: NX_Q9ULV1
    UniProt: Q9ULV1

  • Chr Location
    11q14.2; chr11:86945679-86955395 (-)  GRCh38

Human Diseases
more
  • Diseases
    2 with Fzd4 mouse models; 1 with human FZD4 associations

Human Disease Mouse Models
      
IDs
View 2 models
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    54 phenotypes from 4 alleles in 5 genetic backgrounds
    11 phenotypes from multigenic genotypes
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display abnormalities in hearing, locomotion, retinal morphology, and degeneration of the cerebellum. Homozygous knockout affects retinal angiogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14366 NCBI Gene Model | MGI Sequence Detail 8768 C57BL/6J ±  kb
    transcript NM_008055 RefSeq | MGI Sequence Detail 3685 ZRU/MplStud  
    polypeptide Q61088 UniProt | EBI | MGI Sequence Detail 537 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      Genomic 1
      cDNA 30
      Primer pair 14
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-37564
    References
    more
    • Summaries
      All 152
      Developmental Gene Expression 58
      Diseases 3
      Gene Ontology 27
      Phenotypes 55
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:353442 Luo X, et al., Casein kinase 1alpha mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells. BMC Biol. 2024 Aug 26;22(1):176

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    10/29/2024
    MGI 6.24
    The Jackson Laboratory