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Fzd4tm2.1Nat
Targeted Allele Detail
Summary
Symbol: Fzd4tm2.1Nat
Name: frizzled class receptor 4; targeted mutation 2.1, Jeremy Nathans
MGI ID: MGI:4412057
Synonyms: Fz4CKOAP
Gene: Fzd4  Location: Chr7:89053574-89062341 bp, + strand  Genetic Position: Chr7, 49.32 cM
Alliance: Fzd4tm2.1Nat page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:154020
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsOne loxP site was inserted in the 5' UTR and another was inserted 3' of the 3' UTR. An alkaline phosphatase sequence was inserted 3' of the last loxP site and was followed by an frt flanked PGK-neo cassette. Flp recombinase expression resulted in the excision of the PGK-neo cassette. (J:154020)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fzd4 Mutation:  29 strains or lines available
References
Original:  J:154020 Ye X, et al., Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. Cell. 2009 Oct 16;139(2):285-98
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory