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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fzd4tm2.1Nat
targeted mutation 2.1, Jeremy Nathans
MGI:4412057
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fzd4tm2.1Nat/Fzd4tm2.1Nat involves: 129S1/Sv * 129X1/SvJ MGI:4412187
cn2
 		Fzd4tm1Nat/Fzd4tm2.1Nat
Tg(rx3-icre)1Mjam/? 		involves: 129S1/Sv * 129X1/SvJ MGI:4412190
cn3
 		Fzd4tm1Nat/Fzd4tm2.1Nat
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+ 		involves: 129S1/Sv * 129X1/SvJ MGI:4948328
cn4
 		Fzd4tm1Nat/Fzd4tm2.1Nat
Tg(Tek-cre)1Ywa/0 		involves: 129S1/Sv * 129X1/SvJ MGI:4948329
cn5
 		Fzd4tm1Nat/Fzd4tm2.1Nat
Tg(Tek-cre)1Ywa/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:4412188


Genotype
MGI:4412187
hm1
Allelic
Composition		 Fzd4tm2.1Nat/Fzd4tm2.1Nat
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd4tm2.1Nat mutation (1 available); any Fzd4 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:154020 )
• in the absence of cre mediated recombination, mice have a normal phenotype
• the alkaline phosphatase knock-in is not expressed




Genotype
MGI:4412190
cn2
Allelic
Composition		 Fzd4tm1Nat/Fzd4tm2.1Nat
Tg(rx3-icre)1Mjam/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd4tm1Nat mutation (1 available); any Fzd4 mutation (29 available)
Fzd4tm2.1Nat mutation (1 available); any Fzd4 mutation (29 available)
Tg(rx3-icre)1Mjam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal eye electrophysiology ( J:154020 )
• electroretinogram a wave is relatively normal
• electroretinogram b wave is markedly reduced




Genotype
MGI:4948328
cn3
Allelic
Composition		 Fzd4tm1Nat/Fzd4tm2.1Nat
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd4tm1Nat mutation (1 available); any Fzd4 mutation (29 available)
Fzd4tm2.1Nat mutation (1 available); any Fzd4 mutation (29 available)
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation (3 available); any Gt(ROSA)26Sor mutation (942 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
small kidney ( J:170839 )
• at E18.5 in mice treated with tamoxifen at E12.5 or E13.5




Genotype
MGI:4948329
cn4
Allelic
Composition		 Fzd4tm1Nat/Fzd4tm2.1Nat
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd4tm1Nat mutation (1 available); any Fzd4 mutation (29 available)
Fzd4tm2.1Nat mutation (1 available); any Fzd4 mutation (29 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:170839 )
N
• kidney size is normal




Genotype
MGI:4412188
cn5
Allelic
Composition		 Fzd4tm1Nat/Fzd4tm2.1Nat
Tg(Tek-cre)1Ywa/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd4tm1Nat mutation (1 available); any Fzd4 mutation (29 available)
Fzd4tm2.1Nat mutation (1 available); any Fzd4 mutation (29 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
impaired pupillary reflex ( J:154020 )
• rod and cone signals are not transmitted effectively
abnormal retina vasculature morphology ( J:154020 )
• vascular development on the vitreal face of the retina is retarded
• intra retinal capillaries are completely absent
• vessels from the vitreal surface penetrate the retina and end in ball-like structures
• large vessels are dilated and artery to vein anastomoses develop
• incomplete recombination in retinas creates mosaics in which capillaries form in some region
• vessels from conditionally knocked out regions can integrate into wild type capillary beds
abnormal eye electrophysiology ( J:154020 )
• electroretinogram a wave is relatively normal
• electroretinogram b wave is markedly reduced

behavior/neurological
abnormal optokinetic reflex ( J:154020 )
• rod and cone signals are not transmitted effectively
impaired pupillary reflex ( J:154020 )
• rod and cone signals are not transmitted effectively

nervous system
abnormal brain vasculature morphology ( J:154020 )
• leakage of IgG into the cerebellum

cardiovascular system
abnormal brain vasculature morphology ( J:154020 )
• leakage of IgG into the cerebellum
abnormal retina vasculature morphology ( J:154020 )
• vascular development on the vitreal face of the retina is retarded
• intra retinal capillaries are completely absent
• vessels from the vitreal surface penetrate the retina and end in ball-like structures
• large vessels are dilated and artery to vein anastomoses develop
• incomplete recombination in retinas creates mosaics in which capillaries form in some region
• vessels from conditionally knocked out regions can integrate into wild type capillary beds




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory