73 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Amhr2tm3(cre)Bhr/Amhr2+ Smad2tm1Cxd/Smad2tm1.1Mwst Smad3tm1Par/Smad3tm1Zuk involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal cumulus expansion	J:142827
	abnormal ovarian follicle morphology	J:142827
	decreased litter size	J:142827
	decreased oocyte number	J:142827
	decreased tertiary ovarian follicle number	J:142827
	increased atretic ovarian follicle number	J:142827
	increased circulating follicle stimulating hormone level	J:142827
	increased circulating luteinizing hormone level	J:142827
	premature ovarian failure	J:142827
	reduced female fertility	J:142827
Apctm1Mmt/Apc+ Smad2tm1Kato/Smad2+ involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J	decreased tumor-free survival time	J:79668
	increased intestinal adenoma incidence	J:79668
Apctm1Mmt/Apc+ Smad2tm2Kato/Smad2+ involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J	decreased tumor-free survival time	J:79668
	increased intestinal adenoma incidence	J:79668
M1665Asr/M1665Asr+ Smad2tm1Cxd/Smad2+ involves: 129S6/SvEvTac * Black Swiss * C57BL/6J	increased body weight	J:141536
	increased bone mineral density	J:141536
	increased lean body mass	J:141536
M2195Asr/M2195Asr+ Smad2tm1Cxd/Smad2+ involves: 129S6/SvEvTac * Black Swiss * C57BL/6J	decreased body weight	J:141536
	decreased bone mass	J:141536
	decreased bone mineral content	J:141536
Nodaltm1Rob/Nodal+ Smad2tm1.1Epb/Smad2+ involves: 129S/SvEv * 129X1/SvJ * C57BL/6J * SJL	abnormal eye development	J:183402
	abnormal olfactory epithelium morphology	J:183402
	embryonic growth retardation	J:183402
	holoprosencephaly	J:183402
	proboscis	J:183402
Ppm1atm1.1Xya/Ppm1atm1.1Xya Smad2tm1Xya/Smad2tm1Xya Tg(KRT5-cre)1Xya/0 involves: 129S6/SvEvTac * FVB/N	abnormal wound healing	J:178733
	enhanced wound healing	J:178733
	increased keratinocyte migration	J:178733
Smad2tm1.1Epb/Smad2tm1.1Epb Smad3tm1Cxd/Smad3tm1Cxd involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * SJL	abnormal cell morphology	J:119642
	decreased apoptosis	J:119642
	premature death	J:119642
Smad2tm1.1Epb/Smad2tm1.1Epb Smad3tm1Cxd/Smad3tm1Cxd Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * DBA * SJL	abnormal cell morphology	J:119642
	abnormal cell physiology	J:119642
	increased physiological sensitivity to xenobiotic	J:119642
	normal liver/biliary system phenotype	J:119642
Smad2tm1Cxd/Smad2+ Smad3tm1Cxd/Smad3+ involves: 129S6/SvEvTac * C57BL/6	abnormal Meckel's cartilage morphology	J:76396
Smad2tm1Cxd/Smad2+ Smad3tm1Cxd/Smad3+ involves: 129S6/SvEvTac * NIH Black Swiss	abnormal craniofacial morphology	J:70388, J:106308
	abnormal developmental patterning	J:106308
	abnormal endoderm development	J:106308
	abnormal foregut morphology	J:106308
	abnormal gastrulation	J:106308
	abnormal heart looping	J:106308
	abnormal hepatic cord morphology	J:70388
	abnormal hepatoblast migration	J:106308
	abnormal hepatocyte physiology	J:70388
	abnormal liver morphology	J:70388
	abnormal pericardial cavity morphology	J:106308
	abnormal somite development	J:106308
	cyclopia	J:106308
	decreased hepatocyte proliferation	J:70388
	delayed hepatic development	J:106308
	dilated liver sinusoidal space	J:70388
	embryonic growth retardation	J:106308
	embryonic lethality during organogenesis, incomplete penetrance	J:70388
	holoprosencephaly	J:106308
	increased erythrocyte cell number	J:70388
	increased fetal size	J:70388
	lethality throughout fetal growth and development, complete penetrance	J:106308
	liver hypoplasia	J:70388, J:106308
	small liver	J:70388
	small thyroid gland	J:106308
Smad2tm1Enl/Smad2+ Nodaltm1Rob/Nodal+ involves: 129S/SvEv * 129S4/SvJae	abnormal craniofacial morphology	J:48467
	abnormal direction of embryo turning	J:48467
	abnormal gastrulation	J:48467
	abnormal heart looping	J:48467
	abnormal lateral plate mesoderm morphology	J:48467
	abnormal left-right axis patterning	J:48467
	cyclopia	J:48467
	right pulmonary isomerism	J:48467
	rostral body truncation	J:48467
	transposition of great arteries	J:48467
Smad2tm1Rob/Smad2tm2Rob Smad3tm1Xfw/Smad3+ Edil3Tg(Sox2-cre)1Amc/Edil3+ involves: 129/Sv * 129S/SvEv * C57BL/6 * CBA * CD-1	abnormal heart development	J:84300
	absent foregut	J:84300
	fused somites	J:84300
	rostral body truncation	J:84300
Smad2tm3Rob/Smad2tm3Rob Smad3tm1Xfw/Smad3tm1Xfw involves: 129/Sv * 129S/SvEv * C57BL/6 * ICR	osteoarthritis	J:95374
Smad2tm4(SMADH3)Rob/Smad2tm4(SMADH3)Rob involves: 129S/SvEv * C57BL/6 * ICR	abnormal forebrain development	J:95374
	abnormal hindbrain development	J:95374
	exencephaly	J:95374
	holoprosencephaly	J:95374
	microcephaly	J:95374
	neonatal lethality, incomplete penetrance	J:95374
	prenatal lethality, incomplete penetrance	J:95374
Smad2tm5(SMAD2)Rob/Smad2tm5(SMAD2)Rob involves: 129S/SvEv	embryonic lethality, complete penetrance	J:82809