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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ifnar1
interferon (alpha and beta) receptor 1
MGI:107658
67 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Adarem1Stsn/Adartm1Olds
Ifnar1tm1Agt/Ifnar1tm1Agt
involves: 129S/SvEv * 129S2/SvPas * C57BL/6J 		growth/size/body region phenotype J:308678
normal homeostasis/metabolism phenotype J:308678
normal mortality/aging J:308678
Aim2tm1.2Arte/Aim2tm1.2Arte
Dnase2atm1Osa/Dnase2atm1Osa
Ifnar1tm1Agt/Ifnar1tm1Agt
involves: 129 * BALB/c * C57BL/6 * C57BL/6J 		abnormal spleen morphology J:238323
enlarged spleen J:238323
increased autoantibody level J:238323
increased circulating interleukin-10 level J:238323
increased circulating tumor necrosis factor level J:238323
increased spleen weight J:238323
rheumatoid arthritis J:238323
Dnase2atm1Osa/Dnase2atm1Osa
Ifnar1tm1Agt/Ifnar1tm1Agt
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 		abnormal blood homeostasis J:114982
abnormal cytokine level J:114982
abnormal macrophage morphology J:114982
abnormal spleen morphology J:238323
anemia J:114982
enlarged spleen J:114982, J:238323
increased anti-double stranded DNA antibody level J:114982
increased autoantibody level J:238323
increased circulating interleukin-10 level J:238323
increased circulating interleukin-18 level J:114982
increased circulating tumor necrosis factor level J:114982, J:238323
increased spleen red pulp amount J:114982
increased spleen weight J:238323
joint inflammation J:114982, J:238323
postnatal growth retardation J:114982
rheumatoid arthritis J:114982, J:238323
Dnase2atm1Osa/Dnase2atm1Osa
Ifnar1tm1Agt/Ifnar1tm1Agt
Xkr8tm1.2Osa/Xkr8tm1.2Osa
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 		abnormal Sertoli cell phagocytosis J:293092
Faslpr/Faslpr
Ifnar1tm1Agt/Ifnar1tm1Agt
MRL.Cg-Ifnar1tm1Agt Faslpr 		enlarged lymph nodes J:92084
glomerulonephritis J:92084
increased anti-nuclear antigen antibody level J:92084
increased autoantibody level J:92084
increased IgA level J:92084
increased IgG2b level J:92084
increased IgG3 level J:92084
increased IgG level J:92084
increased IgM level J:92084
increased susceptibility to systemic lupus erythematosus J:92084
increased urine protein level J:92084
salivary gland inflammation J:92084
Faslpr/Faslpr
Ifnar1tm1Agt/Ifnar1tm1Agt
Ifngr1tm1Agt/Ifngr1tm1Agt
MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr 		decreased anti-nuclear antigen antibody level J:92084
decreased autoantibody level J:92084
decreased IgG level J:92084
decreased susceptibility to systemic lupus erythematosus J:92084
glomerulonephritis J:92084
increased IgG level J:92084
increased susceptibility to systemic lupus erythematosus J:92084
increased urine protein level J:92084
salivary gland inflammation J:92084
small lymph nodes J:92084
Ifih1Rgsc422/Ifih1+
Ifnar1tm1Agt/Ifnar1+
involves: 129S2/SvPas * C57BL/6JJcl * DBA/2JJcl 		glomerulonephritis J:209917
Ifnar1tm1Agt/Ifnar1tm1Agt
Ifngr1tm1Agt/Ifngr1tm1Agt
involves: 129S2/SvPas * 129S7/SvEvBrd 		abnormal immunoglobulin level J:101427
normal immune system phenotype J:286237
increased susceptibility to Herpesvirales infection J:81243
increased susceptibility to Herpesvirales infection induced morbidity/mortality J:115139
increased susceptibility to Poxviridae infection J:101427
increased susceptibility to Togaviridae infection J:81243
Ifnar1tm1Agt/Ifnar1tm1Agt
Irf2tm1Mak/Irf2tm1Mak
involves: 129S2/SvPas * C57BL/6 		abnormal skin condition J:66034
Ifnar1tm1Agt/Ifnar1tm1Agt
Myd88tm1Aki/Myd88+
B6.129-Myd88tm1Aki Ifnar1tm1Agt 		increased susceptibility to parasitic infection J:140485
Ifnar1tm1Agt/Ifnar1tm1Agt
Myd88tm1Aki/Myd88tm1Aki
B6.129-Myd88tm1Aki Ifnar1tm1Agt 		increased susceptibility to parasitic infection J:140485
increased susceptibility to parasitic infection induced morbidity/mortality J:140485
Ifnar1tm1Agt/Ifnar1tm1Agt
Myd88tm1Aki/Myd88tm1Aki
involves: 129P2/OlaHsd * 129S2/SvPas 		abnormal leukocyte migration J:171379
Ifnar1tm1Agt/Ifnar1tm1Agt
Otulintm1c(EUCOMM)Hmgu/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0
involves: 129S2/SvPas * C57BL/6 * C57BL/6N * DBA/2 		dermatitis J:312394
normal immune system phenotype J:312394
normal integument phenotype J:312394
Ifnar1tm1Agt/Ifnar1tm1Agt
Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi
involves: 129S2/SvPas * C57BL/6N 		decreased fetal size J:186986
perinatal lethality, complete penetrance J:186986
Ifnar1tm1Agt/Ifnar1tm1Agt
Slamf1tm1Oono/Slamf1tm1Oono
B6.129-Slamf1tm1Oono Ifnar1tm1Agt 		abnormal lymphopoiesis J:117810
increased susceptibility to Paramyxoviridae infection J:117810
Ifnar1tm1Agt/Ifnar1tm1Agt
Sp140em1Vnce/Sp140em1Vnce
B6.Cg-Sp140em1Vnce Ifnar1tm1Agt 		normal immune system phenotype J:313901
Ifnar1tm1Agt/Ifnar1tm1Agt
Tg(CD46)373Zbz/Tg(CD46)373Zbz
involves: 129S2/SvPas * C3H/He * C57BL/6 		abnormal gait J:160878
abnormal neuron physiology J:160878
astrocytosis J:160878
brain inflammation J:160878
increased susceptibility to Paramyxoviridae infection J:160878
increased susceptibility to Paramyxoviridae infection induced morbidity/mortality J:160878
induced hyperactivity J:160878
lethargy J:160878
lung hemorrhage J:160878
lung inflammation J:160878
meningitis J:160878
pulmonary hyperemia J:160878
Ifnar1tm1Agt/Ifnar1tm1Agt
Tg(H2-K1-Ifnb1)10Seif/Tg(H2-K1-Ifnb1)10Seif
C3.Cg-Ifnar1tm1Agt Tg(H2-K1-Ifnb1)10Seif 		normal reproductive system phenotype J:174828
Ifnar1tm1Agt/Ifnar1tm1Agt
Tg(Hmgcr-MX1)LStae/Tg(Hmgcr-MX1)LStae
involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL 		decreased susceptibility to Orthomyxoviridae infection J:119783
decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality J:119783
Ifnar1tm1Agt/Ifnar1tm1Agt
Ythdf3em1Caox/Ythdf3em1Caox
involves: C57BL/6J 		abnormal macrophage physiology J:276397
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory