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Ifngr1tm1Agt
Targeted Allele Detail
Summary
Symbol: Ifngr1tm1Agt
Name: interferon gamma receptor 1; targeted mutation 1, Michel Aguet
MGI ID: MGI:1857286
Synonyms: G129, IFN-gamma R-, IFN-gammaR-, IFN-gammaR-, IFN-gamma R0, IFN-gammaR0, IFN-gammaR1-, IFN-gammaRalpha_, IFN-gamma-R KO, IFN-gammaR KO, IFNgammaR KO, Ifngr-, Ifngr1-, IFNgR KO, IFn type II receptor
Gene: Ifngr1  Location: Chr10:19467697-19485977 bp, + strand  Genetic Position: Chr10, 8.49 cM
Alliance: Ifngr1tm1Agt page
Trpm2tm1.1Alp/Trpm2tm1.1Alp and Ifngr1tm1Agt/Ifngr1tm1Agt mice exhibit increased susceptibility to bacterial infection

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63815
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a neomycin cassette into exon V, which encodes an extracellular membrane-proximal portion of the receptor. (J:61321, J:63815, J:96036)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 12 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Ifngr1tm1Agt
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 13 strains available      Cell Lines: 0 lines available
Carrying any Ifngr1 Mutation:  52 strains or lines available
References
Original:  J:63815 Huang S, et al., Immune response in mice that lack the interferon-gamma receptor [see comments]. Science. 1993 Mar 19;259(5102):1742-5
All:  623 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory