GO Annotations Graph

• Symbol: Xbp1
• Name: X-box binding protein 1
• ID: MGI:98970

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031490	chromatin DNA binding	ISO	J:164563
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:217988
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:195351
Molecular Function	GO:0042826	histone deacetylase binding	IPI	J:217988
Molecular Function	GO:0042826	histone deacetylase binding	IPI	J:215876
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	IPI	J:159304
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:215889
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:215892
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:137188
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0044389	ubiquitin-like protein ligase binding	IPI	J:217988
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:170486
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:215890
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:217988
Cellular Component	GO:0005634	nucleus	IDA	J:170486
Cellular Component	GO:0005634	nucleus	IDA	J:137188
Cellular Component	GO:0005634	nucleus	IDA	J:215876
Cellular Component	GO:0005634	nucleus	IDA	J:159304
Cellular Component	GO:0005634	nucleus	IDA	J:215890
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ISO	J:164563
Biological Process	GO:0060612	adipose tissue development	IMP	J:198494
Biological Process	GO:0001525	angiogenesis	IMP	J:211440
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0006914	autophagy	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0071230	cellular response to amino acid stimulus	IDA	J:211083
Biological Process	GO:0071498	cellular response to fluid shear stress	ISO	J:164563
Biological Process	GO:0071332	cellular response to fructose stimulus	IDA	J:137188
Biological Process	GO:0042149	cellular response to glucose starvation	IDA	J:215889
Biological Process	GO:0071333	cellular response to glucose stimulus	IDA	J:137188
Biological Process	GO:0032869	cellular response to insulin stimulus	IDA	J:159304
Biological Process	GO:0071353	cellular response to interleukin-4	IDA	J:215658
Biological Process	GO:0071499	cellular response to laminar fluid shear stress	ISO	J:164563
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	IEP	J:163558
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:215658
Biological Process	GO:0031670	cellular response to nutrient	IDA	J:159304
Biological Process	GO:0034599	cellular response to oxidative stress	ISO	J:164563
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	IDA	J:198494
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	ISO	J:164563
Biological Process	GO:0042632	cholesterol homeostasis	IMP	J:137188
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IDA	J:211083
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IDA	J:215889
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	ISO	J:155856
Biological Process	GO:0001935	endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0001935	endothelial cell proliferation	IMP	J:211440
Biological Process	GO:0060691	epithelial cell maturation involved in salivary gland development	IMP	J:128972
Biological Process	GO:0060691	epithelial cell maturation involved in salivary gland development	IMP	J:128972
Biological Process	GO:0031017	exocrine pancreas development	IMP	J:128972
Biological Process	GO:0055089	fatty acid homeostasis	IMP	J:137188
Biological Process	GO:0002071	glandular epithelial cell maturation	IMP	J:128972
Biological Process	GO:0002071	glandular epithelial cell maturation	IMP	J:128972
Biological Process	GO:0002071	glandular epithelial cell maturation	IMP	J:128972
Biological Process	GO:0035356	intracellular triglyceride homeostasis	IMP	J:137188
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP	J:147348
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0001889	liver development	IMP	J:59916
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0007517	muscle organ development	IEA	J:60000
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:59916
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO	J:155856
Biological Process	GO:1900102	negative regulation of endoplasmic reticulum unfolded protein response	ISO	J:164563
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0010832	negative regulation of myotube differentiation	IDA	J:215889
Biological Process	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048666	neuron development	IDA	J:211083
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:164563
Biological Process	GO:0045579	positive regulation of B cell differentiation	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response	ISO	J:164563
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	ISO	J:164563
Biological Process	GO:0045600	positive regulation of fat cell differentiation	IMP	J:198494
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation	IMP	J:59916
Biological Process	GO:0031062	positive regulation of histone methylation	ISO	J:164563
Biological Process	GO:0002639	positive regulation of immunoglobulin production	ISO	J:164563
Biological Process	GO:0002639	positive regulation of immunoglobulin production	IDA	J:215658
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:215658
Biological Process	GO:1903489	positive regulation of lactation	IMP	J:198494
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	ISO	J:164563
Biological Process	GO:1900100	positive regulation of plasma cell differentiation	ISO	J:164563
Biological Process	GO:1901985	positive regulation of protein acetylation	ISO	J:164563
Biological Process	GO:0042307	positive regulation of protein import into nucleus	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0045582	positive regulation of T cell differentiation	ISO	J:164563
Biological Process	GO:0032008	positive regulation of TOR signaling	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:217988
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:159304
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:59916
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:215876
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:137188
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:211083
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:195351
Biological Process	GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response	IMP	J:215656
Biological Process	GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response	ISO	J:164563
Biological Process	GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response	IDA	J:215890
Biological Process	GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response	IBA	J:265628
Biological Process	GO:0035470	positive regulation of vascular wound healing	ISO	J:164563
Biological Process	GO:0031648	protein destabilization	ISO	J:164563
Biological Process	GO:0031648	protein destabilization	IMP	J:211083
Biological Process	GO:0015031	protein transport	IEA	J:60000
Biological Process	GO:0010506	regulation of autophagy	IMP	J:211083
Biological Process	GO:0001558	regulation of cell growth	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0031647	regulation of protein stability	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:198494
Biological Process	GO:0051602	response to electrical stimulus	ISO	J:155856
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IDA	J:159304
Biological Process	GO:0034976	response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IDA	J:215658
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IDA	J:215876
Biological Process	GO:1990418	response to insulin-like growth factor stimulus	IDA	J:215889
Biological Process	GO:0006986	response to unfolded protein	IEA	J:60000
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0060096	serotonin secretion, neurotransmission	ISO	J:155856
Biological Process	GO:0055092	sterol homeostasis	IMP	J:137188
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:215889
Biological Process	GO:0006366	transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IMP	J:211083
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	ISO	J:164563