Tyms MGI Mouse Gene Detail - MGI:98878

Symbol

Tyms
Name

thymidylate synthase
Synonyms

TS

Feature Type

protein coding gene
IDs

MGI:98878
NCBI Gene: 22171
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr5:30263200-30278615 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 15.81 cM
Mapping Data

1 experiment

SNPs within 2kb

577 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98878	protein coding gene	Chr5:30243544-30279261 (-)
129S1/SvImJ	ENSMUSG00200010928	protein coding gene	Chr5:25754287-25769539 (-)
A/J	ENSMUSG00195044329	protein coding gene	Chr5:25202380-25217796 (-)
AKR/J	ENSMUSG00220008214	protein coding gene	Chr5:25219529-25234782 (-)
BALB/cJ	ENSMUSG00180028320	protein coding gene	Chr5:25006994-25022409 (-)
C3H/HeJ	ENSMUSG00175042869	protein coding gene	Chr5:26981365-26996779 (-)
C57BL/6NJ	ENSMUSG00215037896	protein coding gene	Chr5:25725722-25741143 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027049	protein coding gene	Chr5:24623728-24638030 (-)
CAST/EiJ	ENSTCUG00005019543	protein coding gene	Chr5:25167783-25206681 (-)
CBA/J	ENSMUSG00210042790	protein coding gene	Chr5:25954590-25970004 (-)
DBA/2J	ENSMUSG00185033291	protein coding gene	Chr5:27817041-27832455 (-)
FVB/NJ	ENSMUSG00205017867	protein coding gene	Chr5:24714837-24730091 (-)
JF1/MsJ	ENSUMUG00000052194	protein coding gene	Chr5:32359791-32374870 (-)
LP/J	ENSMUSG00230040655	protein coding gene	Chr5:32424788-32440040 (-)
NOD/ShiLtJ	ENSMUSG00190011897	protein coding gene	Chr5:25014116-25029531 (-)
NZO/HlLtJ	ENSMUSG00225019744	protein coding gene	Chr5:37641615-37657030 (-)
PWK/PhJ	ENSLUMG00010043977	protein coding gene	Chr5:25113995-25129035 (-)
SPRET/EiJ	no annotation
WSB/EiJ	ENSIUOG00005039336	protein coding gene	Chr5:27916807-27932222 (-)

Human Ortholog

TYMS, thymidylate synthetase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TYMS, thymidylate synthetase
Synonyms

DKCD, HST422, TMS, TS
Links

HGNC:12441

NCBI Gene ID: 7298

UniProt: P04818
Chr Location

18p11.32; chr18:657515-676613 (+) GRCh38

MGI Vertebrate Homology

Tyms stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TYMS
Gene Tree

Tyms

Diseases

9 with human TYMS associations

				Human Disease	Mouse Models
				abdominal aortic aneurysm IDs abdominal aortic aneurysm DOID:7693 EFO:0004214 MESH:D017544 NCI:C27000 OMIM:100070 OMIM:609782 OMIM:611891 OMIM:614375 UMLS_CUI:C0162871
				acute lymphoblastic leukemia IDs acute lymphoblastic leukemia DOID:9952 EFO:0000220 ICD10CM:C91.00 ICD9CM:204.0 NCI:C3167 NCI:C7055 OMIM:247640 OMIM:613065 ORDO:513 UMLS_CUI:C0023449 UMLS_CUI:C1335469
				acute myeloid leukemia IDs acute myeloid leukemia DOID:9119 DOID:9118 DOID:9171 ICD10CM:C92.0 ICD9CM:205.0 KEGG:05221 MESH:D015470 NCI:C3171 OMIM:601626 UMLS_CUI:C0023467
				cerebral infarction IDs cerebral infarction DOID:3526 ICD10CM:I63 MESH:D002544 NCI:C50486 OMIM:601367 UMLS_CUI:C0007785
				colon carcinoma IDs colon carcinoma DOID:1520 NCI:C4910 UMLS_CUI:C0699790
				digenic dyskeratosis congenita IDs digenic dyskeratosis congenita DOID:0060984 OMIM:620040
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				multiple myeloma IDs multiple myeloma DOID:9538 EFO:0001378 ICD10CM:C90.0 ICD9CM:203.0 MESH:D009101 NCI:C3242 OMIM:254500 ORDO:29073 UMLS_CUI:C0026764
				rheumatoid arthritis IDs rheumatoid arthritis DOID:7148 EFO:0000685 ICD10CM:M06.9 ICD9CM:714.0 KEGG:05323 MESH:D001172 NCI:C2884 OMIM:180300 UMLS_CUI:C0003873

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

less

Phenotype Summary

30 phenotype references

All Mutations and Alleles

19
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

8
Radiation induced

3
Spontaneous

1
Targeted

3
Genomic Mutations

6 involving Tyms
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available

less

All GO Annotations

62
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1370
Tissues

166
cDNA Data

60
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tyms

ZFIN tyms

less

All Sequences

72
RefSeq

10
UniProt

11
CCDS

CCDS19154.1

Ensembl

ENSMUSG00000025747 (Evidence)
NCBI Gene

22171

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025747	Ensembl Gene Model \| MGI Sequence Detail	15416	C57BL/6J	± kb
transcript	ENSMUST00000026846	Ensembl \| MGI Sequence Detail	3163	Not Applicable
polypeptide	ENSMUSP00000026846	Ensembl \| MGI Sequence Detail	307	Not Applicable

less

UniProt

11 Sequences
Protein Ontology

PR:000016876 thymidylate synthase

(term hierarchy)
PDB

3IHI, 4E5O, 4EB4, 4EIN, 4EZ8, 5FCT, 6F6Z, 6GKO, 6GYJ, 6Y08
EC

2.1.1.45
InterPro Domains

IPR000398 Thymidylate synthase

IPR020940 Thymidylate synthase, active site

IPR045097 Thymidylate synthase/dCMP hydroxymethylase

IPR023451 Thymidylate synthase/dCMP hydroxymethylase domain

IPR036926 Thymidylate synthase/dCMP hydroxymethylase superfamily
GlyGen

P07607 1 site, 1 O-linked glycan (1 site)

less

All nucleic 71

Genomic 8

cDNA 60

Other 3

Microarray probesets 6

less

MGD-MRK-15313

Summaries

All 83

Developmental Gene Expression 7

Diseases 1

Gene Ontology 13

Phenotypes 30
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tyms:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr50474	Chr5:30278552-30278607 (-)	35 bp
Tssr50473	Chr5:30277362-30277366 (-)	1,251 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24