Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables thymidylate synthase activity. Involved in dTMP biosynthetic process and tetrahydrofolate interconversion. Is active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; cerebral infarction; gastrointestinal system cancer (multiple); hematologic cancer (multiple); and rheumatoid arthritis. Orthologous to human TYMS (thymidylate synthetase).