Hba Complex/Cluster/Region Detail

Summary

• Symbol
  Hba
• Name
  hemoglobin alpha chain complex

• Feature Type
  complex/cluster/region
• IDs
  MGI:96014
  NCBI Gene: 15121
• Cluster Members
  Hba-x, Hba-a1, Hba-a2 (3 members)
• Regulated by
  Rr348, Rr350, Rr349 ... (6 regulatory regions)

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 11, cytoband A
• Mapping Data
  78 experiments

Strain
Comparison

• RFLP
  5

Human Diseases

• Diseases
  1 with Hba mouse models

Human Disease

Mouse Models

alpha thalassemia

IDs

alpha thalassemia      

DOID:1099
ICD10CM:D56.0
ICD9CM:282.43
MESH:D017085
NCI:C34368
OMIM:604131
UMLS_CUI:C0002312

View 8 models

Mouse Models

Human Disease Modeled: alpha thalassemia

Allelic Composition	Genetic Background	Reference	Phenotypes
Hbatm1Ney/Hbatm1Ney	either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)	J:86682	View
Hbab2(th)/Hba+	either: (involves: 101 * SEC) or (involves: 101 * C57BL * SEC)	J:123943	View
Hbab3(th)/Hba+	either: (involves: 101 * SEC) or (involves: 101 * C57BL * SEC)	J:123943	View
Hbath-J/Hba+	involves: C57BL/6J	J:45721 J:32654	View
Hbab2(th)/Hba+	involves: C57BL/6J * SEC	J:32654	View
Hbab3(th)/Hba+	involves: C57BL/6J * SEC	J:32654	View
Hbab2(th)/Hba+	SEC-Hba^b2(th)	J:6452	View
Hbab3(th)/Hba+	SEC-Hba^b3(th)	J:6452	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  6 with disease annotations

• References
  9 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  45 phenotypes from 12 alleles in 14 genetic backgrounds
  78 phenotypes from multigenic genotypes
  253 phenotype references
  

• All Mutations and Alleles
  13
• Chemically induced (ENU)
  2
• Chemically induced (other)
  1
• Radiation induced
  2
• Targeted
  8
• Genomic Mutations
  1 involving Hba
• Find Mice (IMSR)
  10 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for one knock-out allele exhibit lethality during fetal development, reduced size and anemia. Mice homozygous for another knock-out allele exhibit preweaning lethality, pallor and anemia.

Expression

• Assay Results
  18
• Tissues
  16
• Literature Summary
  22

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Sequences &
Gene Models

• NCBI Gene
  15121

Molecular
Reagents

• All nucleic 23

  Genomic 9

  cDNA 4

  Primer pair 1

  Other 9

Other
Accession IDs

MGD-MRK-10623

References

• Summaries
  All 366

  Developmental Gene Expression 22

  Diseases 9

  Phenotypes 253
• Earliest
  J:107 POPP RA, Studies on the mouse hemoglobin loci. II. Position of the hemoglobin locus with respect to albinism and shaker-1 loci. J Hered. 1962 Mar-Apr;53:73-80
• Latest
  J:364463 Xiao L, et al., Fibroblast growth factor 23 neutralizing antibody partially rescues bone loss and increases hematocrit in sickle cell disease mice. Sci Rep. 2025 Mar 28;15(1):10727

Hba expression regulated by:

Feature	Feature Type	Location	Reference
Rr348, regulatory region 348	enhancer	Chr11:32195540-32196033	J:259286
Rr350, regulatory region 350	enhancer	Chr11:32195540-32219344	J:259286
Rr349, regulatory region 349	silencer	Chr11:32200804-32201369	J:267605
Rr351, regulatory region 351	enhancer	Chr11:32206068-32206646	J:184965
Rr352, regulatory region 352	enhancer	Chr11, Syntenic	J:267605
Rr353, regulatory region 353	enhancer	Chr11, Syntenic	J:184965

Hba Cluster contains:

More Data for these features

Member	Feature Type	Location
Hba-x, hemoglobin X, alpha-like embryonic chain in Hba complex	protein coding gene	Chr11:32226600-32228116 (+)
Hba-a1, hemoglobin alpha, adult chain 1	protein coding gene	Chr11:32233672-32234486 (+)
Hba-a2, hemoglobin alpha, adult chain 2	protein coding gene	Chr11:32246489-32247298 (+)