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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Hba
hemoglobin alpha chain complex
MGI:96014
78 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Hba-a1tm1Ywk/Hbath-J
involves: 129X1/SvJ * C57BL/6J
abnormal erythrocyte morphology J:35018
abnormal hemoglobin J:35018
anisocytosis J:35018
decreased fetal size J:35018
hemolytic anemia J:35018
leptocytosis J:35018
pallor J:35018
perinatal lethality, complete penetrance J:35018
poikilocytosis J:35018
polychromatophilia J:35018
reticulocytosis J:35018
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBB*)Tow/Hbbtm2(HBG1,HBB*)Tow
Not Specified
abnormal erythrocyte morphology J:134980
abnormal kidney corticomedullary boundary morphology J:134980
abnormal Kupffer cell morphology J:134980
abnormal liver morphology J:134980
abnormal spleen white pulp morphology J:134980
anemia J:137709
anisocytosis J:134980
decreased erythrocyte cell number J:134980
decreased hematocrit J:134980
decreased hemoglobin content J:134980
decreased urine osmolality J:134980
enlarged spleen J:134980
extramedullary hematopoiesis J:134980
focal hepatic necrosis J:134980
increased liver iron level J:134980
increased spleen red pulp amount J:134980
kidney vascular congestion J:134980
liver vascular congestion J:134980
poikilocytosis J:134980
polychromatophilia J:134980
reticulocytosis J:134980
spleen vascular congestion J:134980
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBB*)Tow/Hbbtm2(HBG1,HBB*)Tow
Slc12a4Rbc10/Slc12a4+
involves: 129 * BALB/c * C57BL/6J
abnormal erythrocyte physiology J:227339
abnormal liver morphology J:227339
abnormal lung morphology J:227339
abnormal pulmonary circulation J:227339
abnormal renal tubule morphology J:227339
enlarged spleen J:227339
hepatic necrosis J:227339
increased mesangial cell number J:227339
liver inflammation J:227339
microcytic anemia J:227339
premature death J:227339
reticulocytosis J:227339
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBB*)Tow/Hbbtm2(HBG1,HBB*)Tow
Slc12a4Rbc10/Slc12a4Rbc10
involves: 129 * BALB/c * C57BL/6J
premature death J:227339
preweaning lethality, incomplete penetrance J:227339
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBB*)Tow/Hbbtm3(HBG1,HBB)Tow
Not Specified
anemia J:137709
normal hematopoietic system phenotype J:134980
normal liver/biliary system phenotype J:134980
normal renal/urinary system phenotype J:134980
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBB*)Tow/Hbbtm3(HBG1,HBB)Tow
Slc12a4Rbc10/Slc12a4Rbc10
involves: 129 * BALB/c * C57BL/6J
microcytic anemia J:227339
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBD,HBB*)Ryan/Hbbtm2(HBG1,HBD,HBB*)Ryan
Not Specified
abnormal proerythroblast morphology J:148521
anemia J:148521
anisopoikilocytosis J:148521
decreased hemoglobin content J:148521
decreased mean corpuscular volume J:148521
extramedullary hematopoiesis J:148521
hemolytic anemia J:148521
increased circulating bilirubin level J:148521
intermingled spleen red and white pulp J:148521
low mean erythrocyte cell number J:148521
polychromatophilia J:148521
premature death J:148521
reticulocytosis J:148521
spherocytosis J:148521
spleen hyperplasia J:148521
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBD,HBB*)Ryan/Hbbtm3(HBG1,HBB)Tow
Not Specified
abnormal definitive hematopoiesis J:148521
decreased hemoglobin content J:148521
decreased mean corpuscular volume J:148521
high mean erythrocyte cell number J:148521
reticulocytosis J:148521
spleen hyperplasia J:148521
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm3(HBG1,HBB)Tow/Hbbtm3(HBG1,HBB)Tow
Not Specified
anemia J:137709
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm4(HBB*)Tow/Hbbtm4(HBB*)Tow
Not Specified
abnormal erythrocyte physiology J:137709
anemia J:137709
normal cardiovascular system phenotype J:137709
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm5(HBG1,HBB*)Tow/Hbbtm5(HBG1,HBB*)Tow
Not Specified
abnormal erythrocyte physiology J:137709
anemia J:137709
normal cardiovascular system phenotype J:137709
Hbatm1Paz/Hba+
Hbbtm1Tow/Hbbtm1Tow
involves: 129S2/SvPas * 129S7/SvEvBrd
abnormal erythroid progenitor cell morphology J:204029
decreased erythroid progenitor cell number J:204029
Hbatm1Paz/Hbatm1Paz
Hbbtm1Tow/Hbb+
involves: 129S2/SvPas * 129S7/SvEvBrd
normal hematopoietic system phenotype J:204029
Hbatm1Paz/Hbatm1Paz
Hbbtm1Tow/Hbbtm1Tow
involves: 129S2/SvPas * 129S7/SvEvBrd
abnormal embryonic erythrocyte morphology J:204029
abnormal embryonic erythropoiesis J:204029
abnormal erythroid progenitor cell morphology J:204029
decreased embryo size J:204029
decreased erythroid progenitor cell number J:204029
embryonic lethality during organogenesis, complete penetrance J:204029
liver hypoplasia J:204029
microcytic anemia J:204029
microcytosis J:204029
pallor J:204029
small liver J:204029
Hbatm1Paz/Hbatm1Paz
Hbbtm1Tow/Hbbtm1Tow
Tg(HBA-HBBs)41Paz/0
involves: 129 * Black Swiss * C57BL/6 * DBA/2 * FVB/N
abnormal penile erection J:135978
priapism J:135978
Hbatm1Paz/Hbatm1Paz
Hbbtm1Tow/Hbbtm1Tow
Tg(HBA-HBBs)41Paz/?
involves: 129S2/SvPas * 129S7/SvEvBrd * Black Swiss * C57BL/6 * DBA/2* FVB/N
abnormal erythrocyte morphology J:44161
abnormal hemoglobin J:44161
abnormal kidney vasculature morphology J:44161
abnormal liver vasculature morphology J:44161
abnormal lung vasculature morphology J:44161
anemia J:44161
anisopoikilocytosis J:44161
decreased erythrocyte osmotic fragility J:44161
decreased hematocrit J:44161
decreased mean corpuscular hemoglobin J:44161
decreased mean corpuscular hemoglobin concentration J:44161
decreased mean corpuscular volume J:44161
hypoxia J:44161
increased heart weight J:44161
increased kidney iron level J:44161
increased kidney weight J:44161
increased liver iron level J:44161
increased spleen weight J:44161
kidney atrophy J:44161
kidney cyst J:44161
neonatal lethality, incomplete penetrance J:44161
renal fibrosis J:44161
reticulocytosis J:44161
spleen vascular congestion J:44161

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory