Rr350 Other Genome Feature Detail

Summary

• Symbol
  Rr350
• Name
  regulatory region 350
• Synonyms
  Erythroid super-enhancer SE

• Feature Type
  enhancer
• IDs
  MGI:7432648
• Cluster Members
  Rr348, Rr349, Rr351 ... (5 members)
• Regulates expression of
  Hba (1 regulated gene)

Location &
Maps

• Sequence Map
  Chr11:32195540-32219344 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• J:259286: R1-R4 chr11:32145540-32169344 (NCBIm37) chr11:32195540-32219344 (GRCm39)

• Genetic Map
  Chromosome 11, Syntenic

Strain
Comparison

• SNPs within 2kb
  688 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotype references
  

• All Mutations and Alleles
  4
• Endonuclease-mediated
  1
• Targeted
  3
• Genomic Mutations
  1 involving Rr350
• Find Mice (IMSR)
  0 strains or lines available

References

• Summaries
  All 3

  Phenotypes 2
• Earliest
  J:259286 Hay D, et al., Genetic dissection of the alpha-globin super-enhancer in vivo. Nat Genet. 2016 Aug;48(8):895-903
• Latest
  J:366854 Kassouf MT, et al., The alpha-globin super-enhancer acts in an orientation-dependent manner. Nat Commun. 2025 Jan 25;16(1):1033

Rr350 regulates expression of:

Feature	Feature Type	Location	Reference
Hba, hemoglobin alpha chain complex	complex/cluster/region	Chr11, cytoband A	J:259286

Rr350 Cluster contains:

More Data for these features

Member	Feature Type	Location
Rr348, regulatory region 348	enhancer	Chr11:32195540-32196033
Rr349, regulatory region 349	silencer	Chr11:32200804-32201369
Rr351, regulatory region 351	enhancer	Chr11:32206068-32206646
Rr352, regulatory region 352	enhancer	Chr11, Syntenic
Rr353, regulatory region 353	enhancer	Chr11, Syntenic