Hba Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hba
hemoglobin alpha chain complex
MGI:96014

45 phenotypes from 12 alleles in 14 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hba^b2(th)/Hba⁺ either: (involves: 101 * SEC) or (involves: 101 * C57BL * SEC)	acanthocytosis	J:86011
	anisocytosis	J:123943
	anisopoikilocytosis	J:86011
	dacryocytosis	J:86011
	decreased hematocrit	J:123943
	decreased hemoglobin content	J:123943
	decreased mean corpuscular hemoglobin	J:123943
	decreased mean corpuscular volume	J:123943
	hypochromic microcytic anemia	J:123943
	increased erythrocyte cell number	J:123943
	increased leukocyte cell number	J:123943
	leptocytosis	J:86011
	microcytosis	J:123943
	poikilocytosis	J:86011
	reticulocytosis	J:123943
Hba^b2(th)/Hba⁺ involves: 101/Rl * SEC/Rl	abnormal hemoglobin	J:5686
	increased erythrocyte clearance	J:150481
	premature death	J:150481
Hba^b2(th)/Hba⁺ involves: C57BL/6J * SEC	postnatal lethality	J:32654
Hba^b2(th)/Hba⁺ SEC-Hba^b2(th)	abnormal fetal derived definitive erythrocyte morphology	J:6452
Hba^b2(th)/Hba⁺ SEC-Hba^b2(th)	normal growth/size/body region phenotype	J:6452
Hba^b2(th)/Hba^b2(th) SEC-Hba^b2(th)	embryonic growth retardation	J:6452
	embryonic lethality between implantation and somite formation, incomplete penetrance	J:6452
	trophectoderm cell degeneration	J:6452
Hba^b3(th)/Hba⁺ either: (involves: 101 * SEC) or (involves: 101 * C57BL * SEC)	acanthocytosis	J:86011
	anisocytosis	J:123943
	anisopoikilocytosis	J:86011
	dacryocytosis	J:86011
	decreased hematocrit	J:123943
	decreased hemoglobin content	J:123943
	decreased mean corpuscular hemoglobin	J:123943
	decreased mean corpuscular volume	J:123943
	hypochromic microcytic anemia	J:123943
	increased erythrocyte cell number	J:123943
	leptocytosis	J:86011
	microcytosis	J:123943
	poikilocytosis	J:86011
	reticulocytosis	J:123943
Hba^b3(th)/Hba⁺ involves: 101 * SEC	abnormal hemoglobin	J:5686
Hba^b3(th)/Hba⁺ involves: C57BL/6J * SEC	postnatal lethality	J:32654
Hba^b3(th)/Hba⁺ SEC-Hba^b3(th)	abnormal fetal derived definitive erythrocyte morphology	J:6452
	decreased birth body size	J:6452
	decreased body weight	J:6452
	postnatal lethality, incomplete penetrance	J:6452
Hba^b3(th)/Hba^b3(th) SEC-Hba^b3(th)	embryonic growth retardation	J:6452
	embryonic lethality between implantation and somite formation, incomplete penetrance	J:6452
	trophectoderm cell degeneration	J:6452
Hba^c2/Hba^c2 involves: C3H/HeH	no abnormal phenotype detected	J:185113
Hba^g2/Hba^g2 involves: C57BL/6J * DBA/2J	no abnormal phenotype detected	J:7188
Hba^th-J/Hba⁺ B6.Cg-Hba^th-J	maternal effect	J:29127
Hba^th-J/Hba⁺ involves: C57BL/6J	decreased body weight	J:45721
	decreased hemoglobin content	J:45721
	increased erythrocyte cell number	J:45721
	microcytosis	J:45721
	postnatal lethality	J:32654
Hba^th-J/Hba^th-J involves: C57BL/6J	abnormal blastocyst morphology	J:29665
	abnormal inner cell mass morphology	J:29665
	abnormal trophectoderm morphology	J:29665
	embryonic lethality between implantation and somite formation, complete penetrance	J:29665
Hba^tm1.1Ney/Hba^tm1.1Ney either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)	no abnormal phenotype detected	J:86682
Hba^tm1Ney/Hba^tm1Ney either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)	abnormal erythrocyte morphology	J:86682
	anemia	J:86682
	anisopoikilocytosis	J:86682
	decreased hemoglobin content	J:86682
	decreased mean corpuscular hemoglobin	J:86682
	decreased mean corpuscular volume	J:86682
	hydrops fetalis	J:86682
	increased erythrocyte cell number	J:86682
	leptocytosis	J:86682
	pallor	J:86682
	preweaning lethality, incomplete penetrance	J:86682
	reticulocytosis	J:86682
	schistocytosis	J:86682
Hba^tm1Paz/Hba⁺ involves: 129S7/SvEvBrd	decreased hemoglobin content	J:117887
	decreased mean corpuscular hemoglobin	J:117887
	decreased mean corpuscular volume	J:117887
	reticulocytosis	J:117887
Hba^tm1Paz/Hba^tm1Paz involves: 129S7/SvEvBrd	abnormal erythrocyte morphology	J:28392
	decreased fetal size	J:28392
	decreased mean corpuscular hemoglobin	J:28392
	decreased mean corpuscular volume	J:28392
	hydrops fetalis	J:28392
	lethality throughout fetal growth and development, complete penetrance	J:28392
Rhbdf1/Hba^{tm1(RHBDF1/HBA)Ajhs}/Hba⁺ involves: 129P2/OlaHsd * C57BL/6 * CBA	anisopoikilocytosis	J:117887
Rhbdf1/Hba^{tm1(RHBDF1/HBA)Ajhs}/Rhbdf1/Hba^{tm1(RHBDF1/HBA)Ajhs} involves: 129P2/OlaHsd * C57BL/6 * CBA	anisopoikilocytosis	J:117887
	decreased hemoglobin content	J:117887
	decreased mean corpuscular hemoglobin	J:117887
	decreased mean corpuscular volume	J:117887
	microcytosis	J:117887
	neonatal lethality, incomplete penetrance	J:117887
	prenatal lethality, incomplete penetrance	J:117887
	reticulocytosis	J:117887
Rhbdf1/Hba^{tm1.1(RHBDF1/HBA)Ajhs}/Rhbdf1/Hba^{tm1.1(RHBDF1/HBA)Ajhs} involves: 129P2/OlaHsd * C57BL/6 * CBA	decreased hemoglobin content	J:117887
	decreased mean corpuscular hemoglobin	J:117887
	decreased mean corpuscular volume	J:117887
	reticulocytosis	J:117887
Rhbdf1/Hba^tm2.1Ajhs/Hba⁺ involves: 129P2/OlaHsd * C57BL/6	decreased hemoglobin content	J:117887
	decreased mean corpuscular hemoglobin	J:117887
	decreased mean corpuscular volume	J:117887
Rhbdf1/Hba^tm2Ajhs/Hba⁺ involves: 129P2/OlaHsd * C57BL/6	anisopoikilocytosis	J:117887
	decreased hemoglobin content	J:117887
	decreased mean corpuscular hemoglobin	J:117887
	decreased mean corpuscular volume	J:117887
	microcytosis	J:117887
Rhbdf1/Hba^tm2Ajhs/Rhbdf1/Hba^tm2Ajhs involves: 129P2/OlaHsd * C57BL/6	anemia	J:117887
	decreased embryo size	J:117887
	embryonic lethality during organogenesis, complete penetrance	J:117887
	pallor	J:117887

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24