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Tmem97 Gene Detail
Summary
  • Symbol
    Tmem97
  • Name
    transmembrane protein 97
  • Synonyms
    1810014L12Rik, D11Bhm182e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916321
    NCBI Gene: 69071
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:78432643-78441561 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 46.74 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    286 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916321
 protein coding gene Chr11:78432643-78441603 (-)
129S1/SvImJ ENSMUSG00200051050
 protein coding gene Chr11:75549523-75558483 (-)
A/J ENSMUSG00195044310
 protein coding gene Chr11:75428323-75437283 (-)
AKR/J ENSMUSG00220048141
 protein coding gene Chr11:75652262-75661223 (-)
BALB/cJ ENSMUSG00180032690
 protein coding gene Chr11:75617123-75626083 (-)
C3H/HeJ ENSMUSG00175028345
 protein coding gene Chr11:75586344-75595304 (-)
C57BL/6NJ ENSMUSG00215041421
 protein coding gene Chr11:75210346-75219308 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016814
 protein coding gene Chr11:73482971-73492077 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210033713
 protein coding gene Chr11:75410080-75419040 (-)
DBA/2J ENSMUSG00185038831
 protein coding gene Chr11:75674784-75683744 (-)
FVB/NJ ENSMUSG00205043915
 protein coding gene Chr11:75504382-75513626 (-)
JF1/MsJ ENSUMUG00000042783
 protein coding gene Chr11:76055743-76064874 (-)
LP/J ENSMUSG00230042400
 protein coding gene Chr11:76705219-76714179 (-)
NOD/ShiLtJ ENSMUSG00190030430
 protein coding gene Chr11:75721836-75730796 (-)
NZO/HlLtJ ENSMUSG00225036738
 protein coding gene Chr11:78872737-78881697 (-)
PWK/PhJ ENSLUMG00010019059
 protein coding gene Chr11:75580350-75589485 (-)
SPRET/EiJ ENSMSPG00010031548
 protein coding gene Chr11:75990018-75999307 (-)
WSB/EiJ ENSIUOG00005027615
 protein coding gene Chr11:75564903-75573863 (-)



Homology
more
  • Human Ortholog
    TMEM97, transmembrane protein 97
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM97, transmembrane protein 97
  • Synonyms
    MAC30, S2R, sigma2R
  • Links
    NCBI Gene ID: 27346
    UniProt: Q5BJF2

  • Chr Location
    17q11.2; chr17:28319200-28328685 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice exhibit normal male fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    958
  • Tissues
    61
  • cDNA Data
    128
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69071 NCBI Gene Model | MGI Sequence Detail 8919 C57BL/6J ±  kb
    transcript NM_133706 RefSeq | MGI Sequence Detail 1333 ZRU/MplStud  
    polypeptide Q8VD00 UniProt | EBI | MGI Sequence Detail 176 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 137
      Genomic 8
      cDNA 128
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35365, MGI:106904, MGI:2144068, MGI:2144345
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 28
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:375187 Li J, et al., TMEM97 governs partial epithelial-mesenchymal transition of retinal pigment epithelial cells via the CTNND2-ADAM10 axis. Mol Ther Nucleic Acids. 2025 Mar 11;36(1):102460
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory