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Cisd2 Gene Detail
Summary
  • Symbol
    Cisd2
  • Name
    CDGSH iron sulfur domain 2
  • Synonyms
    1500009M05Rik, 1500026J14Rik, 1500031D15Rik, B630006A20Rik, Miner1, Zcd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914256
    NCBI Gene: 67006
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:135112173-135129194 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 62.55 cM, cytoband H2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    542 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914256
 protein coding gene Chr3:135112173-135129686 (-)
129S1/SvImJ ENSMUSG00200002651
 protein coding gene Chr3:131883453-131900228 (-)
A/J ENSMUSG00195004206
 protein coding gene Chr3:132009889-132027404 (-)
AKR/J ENSMUSG00220022360
 protein coding gene Chr3:130461761-130479299 (-)
BALB/cJ ENSMUSG00180011689
 protein coding gene Chr3:131931661-131949176 (-)
C3H/HeJ ENSMUSG00175018152
 protein coding gene Chr3:131532607-131550120 (-)
C57BL/6NJ ENSMUSG00215016497
 protein coding gene Chr3:132269902-132287417 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025658
 protein coding gene Chr3:128670941-128688457 (-)
CAST/EiJ ENSTCUG00005003642
 protein coding gene Chr3:132601774-132618499 (-)
CBA/J ENSMUSG00210031844
 protein coding gene Chr3:132122485-132139999 (-)
DBA/2J ENSMUSG00185003319
 protein coding gene Chr3:132760281-132777811 (-)
FVB/NJ ENSMUSG00205017525
 protein coding gene Chr3:131074265-131091793 (-)
JF1/MsJ ENSUMUG00000018610
 protein coding gene Chr3:131489621-131506329 (-)
LP/J ENSMUSG00230002114
 protein coding gene Chr3:134697486-134714258 (-)
NOD/ShiLtJ ENSMUSG00190004433
 protein coding gene Chr3:133139216-133156745 (-)
NZO/HlLtJ ENSMUSG00225005289
 protein coding gene Chr3:137178622-137196158 (-)
PWK/PhJ ENSLUMG00010014777
 protein coding gene Chr3:131418810-131435547 (-)
SPRET/EiJ ENSMSPG00010013190
 protein coding gene Chr3:132554213-132568548 (-)
WSB/EiJ ENSIUOG00005017755
 protein coding gene Chr3:132252439-132269224 (-)



Homology
more
  • Human Ortholog
    CISD2, CDGSH iron sulfur domain 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CISD2, CDGSH iron sulfur domain 2
  • Synonyms
    ERIS, Miner1, NAF-1, WFS2, ZCD2
  • Links
    NCBI Gene ID: 493856
    UniProt: Q8N5K1

  • Chr Location
    4q24; chr4:102868971-102892807 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CISD2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 2 alleles in 2 genetic backgrounds
    41 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit numerous symptoms of premature aging associated with reduced mitochondrial degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    638
  • Tissues
    27
  • cDNA Data
    94
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67006 NCBI Gene Model | MGI Sequence Detail 17022 C57BL/6J ±  kb
    transcript NM_025902 RefSeq | MGI Sequence Detail 2885 C57BL/6  
    polypeptide Q9CQB5 UniProt | EBI | MGI Sequence Detail 135 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000005502 CDGSH iron-sulfur domain-containing protein 2
      (term hierarchy)
    • InterPro Domains
      IPR045131 CDGSH iron-sulfur domain-containing protein 1/2
      IPR018967 Iron-binding zinc finger, CDGSH type
      IPR019610 Iron sulphur domain-containing, mitoNEET, N-terminal
      IPR042216 MitoNEET, CDGSH iron-sulfur domain
    Molecular
    Reagents
    less
    • All nucleic 94
      cDNA 94

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1916247, MGI:1916261, MGI:2139813, MGI:2442890
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 9
      Phenotypes 31
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:372092 Chou YJ, et al., Activation of CISD2 as a protective strategy against doxorubicin-induced cardiotoxicity. Redox Biol. 2025 Aug 22;86:103840
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/15/2026
    MGI 6.29     		The Jackson Laboratory