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Targeted Allele Detail
Symbol: Cisd2tm1Tfts
Name: CDGSH iron sulfur domain 2; targeted mutation 1, Ting-Fen Tsai
MGI ID: MGI:3846404
Gene: Cisd2  Location: Chr3:135112173-135129194 bp, - strand  Genetic Position: Chr3, 62.55 cM, cytoband H2
Alliance: Cisd2tm1Tfts page
Germline Transmission:  Earliest citation of germline transmission: J:148467
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Duplication, Insertion
  Cisd2tm1Tfts involves 1 genes/genome features (Cisd2) View all
Mutation detailsThe genomic sequence extending from the 3' end of intron 1 through the 5' end of exon 3 was replaced with the missing portion of intron 1 through the 5' end of exon 3 following by a puromycin resistance cassette, loxP site, 3'Hprt mini-gene, and a duplication of the 3' end of intron 1 through the 5' end of exon 3. The absence of transcript expression was confirmed by northern blot analysis on brain extracts. (J:148467)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cisd2 Mutation:  34 strains or lines available
Original:  J:148467 Chen YF, et al., Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice. Genes Dev. 2009 May 15;23(10):1183-94
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory