Ppdpf MGI Mouse Gene Detail - MGI:1913746 - pancreatic progenitor cell differentiation and proliferation factor

Symbol

Ppdpf
Name

pancreatic progenitor cell differentiation and proliferation factor
Synonyms

0610012G23Rik, 2610317A05Rik, 2700038C09Rik, 3110053G12Rik

Feature Type

protein coding gene
IDs

MGI:1913746
NCBI Gene: 66496
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:180829040-180830564 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 103.62 cM
Mapping Data

1 experiment

SNPs within 2kb

53 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913746	protein coding gene	Chr2:180828615-180830564 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027012	protein coding gene	Chr2:187762557-187764081 (+)
A/J	MGP_AJ_G0026978	protein coding gene	Chr2:180037625-180039149 (+)
AKR/J	MGP_AKRJ_G0026948	protein coding gene	Chr2:185431627-185433151 (+)
BALB/cJ	MGP_BALBcJ_G0026987	protein coding gene	Chr2:180503479-180505003 (+)
C3H/HeJ	MGP_C3HHeJ_G0026728	protein coding gene	Chr2:185788161-185789685 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027433	protein coding gene	Chr2:193182663-193184659 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024798	protein coding gene	Chr2:170725416-170726942 (+)
CAST/EiJ	MGP_CASTEiJ_G0026187	protein coding gene	Chr2:184045368-184046892 (+)
CBA/J	MGP_CBAJ_G0026705	protein coding gene	Chr2:200184884-200186408 (+)
DBA/2J	MGP_DBA2J_G0026843	protein coding gene	Chr2:179130874-179132398 (+)
FVB/NJ	MGP_FVBNJ_G0026809	protein coding gene	Chr2:177747806-177749330 (+)
LP/J	MGP_LPJ_G0026944	protein coding gene	Chr2:187774284-187775808 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026828	protein coding gene	Chr2:202753683-202755207 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027492	protein coding gene	Chr2:185400612-185402136 (+)
PWK/PhJ	MGP_PWKPhJ_G0025923	protein coding gene	Chr2:176656229-176657753 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025723	protein coding gene	Chr2:181888281-181892078 (+)
WSB/EiJ	MGP_WSBEiJ_G0026259	protein coding gene	Chr2:186386624-186388148 (+)

Human Ortholog

PPDPF, pancreatic progenitor cell differentiation and proliferation factor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPDPF, pancreatic progenitor cell differentiation and proliferation factor
Synonyms

C20orf149, dJ697K14.9, exdpf
Links

HGNC:16142

NCBI Gene ID: 79144

neXtProt AC: NX_Q9H3Y8

UniProt: Q9H3Y8
Chr Location

20q13.33; chr20:63520741-63522206 (+) GRCh38

MGI Vertebrate Homology

Ppdpf stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PPDPF
Gene Tree

Ppdpf

Diseases

1 with Ppdpf mouse models

Human Disease

Mouse Models

metabolic dysfunction-associated steatotic liver disease

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

1
Gene trapped

10
Targeted

5
Incidental Mutations

APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Liver-specific knock-out mice develop fatty liver disease.

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All GO Annotations

1
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

719
Tissues

8
cDNA Data

16
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppdpf

ZFIN ppdpfa, ppdpfb

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All Sequences

54
RefSeq

7
UniProt

1
CCDS

CCDS17202.1

Ensembl

ENSMUSG00000016344 (Evidence)
NCBI Gene

66496

			Length	Strain/Species	Flank
genomic	ENSMUSG00000016344	Ensembl Gene Model \| MGI Sequence Detail	1525	C57BL/6J	± kb
transcript	ENSMUST00000016488	Ensembl \| MGI Sequence Detail	1160	Not Applicable
polypeptide	ENSMUSP00000016488	Ensembl \| MGI Sequence Detail	115	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007244 exocrine differentiation and proliferation factor

(term hierarchy)
InterPro Domains

IPR026754 Pancreatic progenitor cell differentiation and proliferation factor

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All nucleic 16

cDNA 16

Microarray probesets 5

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MGI:1913313, MGI:1919783, MGI:1920465

Summaries

All 33

Developmental Gene Expression 2

Diseases 1

Gene Ontology 1

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:329185 Zheng QW, et al., PPDPF promotes lung adenocarcinoma progression via inhibiting apoptosis and NK cell-mediated cytotoxicity through STAT3. Oncogene. 2022 Sep;41(36):4244-4256

TSS for Ppdpf:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr22287	Chr2:180829068-180829140 (+)	64 bp
Tssr22288	Chr2:180829168-180829212 (+)	150 bp
Tssr22289	Chr2:180829302-180829388 (+)	305 bp
Tssr22290	Chr2:180829390-180829411 (+)	361 bp
Tssr22291	Chr2:180829429-180829445 (+)	397 bp
Tssr22292	Chr2:180829572-180829601 (+)	547 bp
Tssr22293	Chr2:180829670-180829709 (+)	650 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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