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Stk39 Gene Detail
Summary
  • Symbol
    Stk39
  • Name
    serine/threonine kinase 39
  • Synonyms
    DCHT, RF005, Rnl5, SPAK
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858416
    NCBI Gene: 53416
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:68040789-68302381 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 39.53 cM, cytoband C3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2236 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858416
 protein coding gene Chr2:68040789-68302612 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025790
 protein coding gene Chr2:68105698-68390580 (-)
A/J MGP_AJ_G0025767
 protein coding gene Chr2:65485046-65753452 (-)
AKR/J MGP_AKRJ_G0025736
 protein coding gene Chr2:67260786-67532818 (-)
BALB/cJ MGP_BALBcJ_G0025762
 protein coding gene Chr2:65670627-65937996 (-)
C3H/HeJ MGP_C3HHeJ_G0025522
 protein coding gene Chr2:67470787-67748071 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026209
 protein coding gene Chr2:70156103-70438299 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023612
 protein coding gene Chr2:62755511-63016245 (-)
CAST/EiJ MGP_CASTEiJ_G0024986
 protein coding gene Chr2:67570857-67869889 (-)
CBA/J MGP_CBAJ_G0025502
 protein coding gene Chr2:72724663-73028036 (-)
DBA/2J MGP_DBA2J_G0025633
 protein coding gene Chr2:65137241-65408336 (-)
FVB/NJ MGP_FVBNJ_G0025596
 protein coding gene Chr2:64514067-64780294 (-)
LP/J MGP_LPJ_G0025722
 protein coding gene Chr2:67969313-68246238 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025625
 protein coding gene Chr2:74824426-75122052 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026266
 protein coding gene Chr2:67319909-67598376 (-)
PWK/PhJ MGP_PWKPhJ_G0024727
 protein coding gene Chr2:64958640-65228548 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024534
 protein coding gene Chr2:67534399-67815964 (-)
WSB/EiJ MGP_WSBEiJ_G0025054
 protein coding gene Chr2:67762250-68040250 (-)



Homology
more
  • Human Ortholog
    STK39, serine/threonine kinase 39
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STK39, serine/threonine kinase 39
  • Synonyms
    DCHT, PASK, SPAK
  • Links
    NCBI Gene ID: 27347
    neXtProt AC: NX_Q9UEW8
    UniProt: Q9UEW8

  • Chr Location
    2q24.3; chr2:167954020-168247595 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Stk39 mouse models

Human Disease Mouse Models
      
IDs
 View 3 models
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 7 alleles in 7 genetic backgrounds
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced bumetanide-sensitive thallium, a potassium tracer, uptake in dorsal root ganglion neurons and reduced fertility. Mice with an ENU mutation in intron 8 exhibit elevated albumin-creatinine (ACR) ratios.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    83
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
DNA-templated transcription
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    766
  • Tissues
    15
  • cDNA Data
    99
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53416 NCBI Gene Model | MGI Sequence Detail 261593 C57BL/6J ±  kb
    transcript NM_016866 RefSeq | MGI Sequence Detail 3303 ZRU/MplStud  
    polypeptide Q9Z1W9 UniProt | EBI | MGI Sequence Detail 556 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 100
      cDNA 99
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2139330, MGI:2139399, MGI:3844884
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 4
      Diseases 3
      Gene Ontology 21
      Phenotypes 43
    • Earliest
      J:62150 Johnston AM, et al., SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. Oncogene. 2000 Aug 31;19(37):4290-7
    • Latest
      J:342289 Grimm PR, et al., Dietary potassium stimulates Ppp1Ca-Ppp1r1a dephosphorylation of kidney NaCl cotransporter and reduces blood pressure. J Clin Invest. 2023 Nov 1;133(21)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/21/2023
    MGI 6.22     		The Jackson Laboratory