Stk39^tm2.1Arte
Targeted Allele Detail

Summary

• Symbol: Stk39^tm2.1Arte
• Name: serine/threonine kinase 39; targeted mutation 2.1, TaconicArtemis
• MGI ID: MGI:5770425
• Synonyms: SPAK^L502A
• Gene: Stk39 Location: Chr2:68040789-68302381 bp, - strand Genetic Position: Chr2, 39.53 cM, cytoband C3
• Alliance: Stk39^tm2.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224087
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 16 was replaced with a modified exon 16 in which nucleotide substitutions result in the amino acid substitution of alanine for leucine at position 502 (L502A) in the conserved carboxy-terminal (CCT) domain. Flp-mediated recombination removed an FRT-flanked puromycin cassette inserted in intron 15. This mutation suppresses protein phosphorylation by WNK isoforms and results in markedly reduced phosphorylation and expression of sodium ion co-transporters NCC and NKCC2 in the kidney. (J:224087)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk39 Mutation: 44 strains or lines available

References

• Original: J:224087 Zhang J, et al., Critical role of the SPAK protein kinase CCT domain in controlling blood pressure. Hum Mol Genet. 2015 Aug 15;24(16):4545-58
• All: 2 reference(s)