Sequence Detail

ID/Version

Q9Z1W9 Q80W13 (UniProt | EBI)

Last sequence update: 1999-05-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=STE20/SPS1-related proline-alanine-rich protein kinase; Short=Ste-20-related kinase; EC=2.7.11.1 {ECO:0000269|PubMed:16382158};AltName: Full=Serine/threonine-protein kinase 39;

Provider

SWISS-PROT

Sequence

Polypeptide 556 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Stk39	serine/threonine kinase 39	86	106	3	16

Sequence references in MGI

J:62150 Johnston AM, et al., SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. Oncogene. 2000 Aug 31;19(37):4290-7
J:129716 Yang SS, et al., Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab. 2007 May;5(5):331-44
J:139340 Piechotta K, et al., Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase. J Biol Chem. 2003 Dec 26;278(52):52848-56
J:152915 Ohta A, et al., Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. Hum Mol Genet. 2009 Oct 15;18(20):3978-86
J:162573 Reiche J, et al., SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2. Mol Cell Biol. 2010 Jun;30(12):3027-37
J:172037 Yang D, et al., IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest. 2011 Mar 1;121(3):956-65
J:177214 Rinehart J, et al., WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters. J Biol Chem. 2011 Aug 26;286(34):30171-80
J:182953 Chiga M, et al., Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade. J Cell Sci. 2011 May 1;124(Pt 9):1391-5
J:220505 Park S, et al., Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice. Gastroenterology. 2013 Jul;145(1):232-41
J:265615 Polek TC, et al., The TNF receptor, RELT, binds SPAK and uses it to mediate p38 and JNK activation. Biochem Biophys Res Commun. 2006 Apr 28;343(1):125-34
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89