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Mapk8ip1 Gene Detail
Summary
  • Symbol
    Mapk8ip1
  • Name
    mitogen-activated protein kinase 8 interacting protein 1
  • Synonyms
    IB1, Jip1, JIP-1, MAPK8IP1, mjip-2a, Prkm8ip, Skip
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309464
    NCBI Gene: 19099
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:92214021-92231608 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 50.99 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    342 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1309464
protein coding gene Chr2:92214021-92231608 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026167
protein coding gene Chr2:93814340-93831908 (-)
A/J MGP_AJ_G0026128
protein coding gene Chr2:90017305-90034827 (-)
AKR/J MGP_AKRJ_G0026109
protein coding gene Chr2:92506582-92525712 (-)
BALB/cJ MGP_BALBcJ_G0026137
protein coding gene Chr2:90201675-90219172 (-)
C3H/HeJ MGP_C3HHeJ_G0025888
protein coding gene Chr2:92812520-92830051 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026588
protein coding gene Chr2:97029622-97047131 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023979
protein coding gene Chr2:86509540-86526964 (-)
CAST/EiJ MGP_CASTEiJ_G0025353
protein coding gene Chr2:93358687-93376199 (-)
CBA/J MGP_CBAJ_G0025866
protein coding gene Chr2:100415605-100433353 (-)
DBA/2J MGP_DBA2J_G0026002
protein coding gene Chr2:89610367-89627932 (-)
FVB/NJ MGP_FVBNJ_G0025965
protein coding gene Chr2:88721173-88739001 (-)
LP/J MGP_LPJ_G0026106
protein coding gene Chr2:94010403-94028137 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025991
protein coding gene Chr2:103374054-103392560 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026642
protein coding gene Chr2:92590138-92607733 (-)
PWK/PhJ MGP_PWKPhJ_G0025088
protein coding gene Chr2:89355988-89373550 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024889
protein coding gene Chr2:92160272-92179490 (-)
WSB/EiJ MGP_WSBEiJ_G0025420
protein coding gene Chr2:93208186-93228644 (-)



Homology
more
  • Human Ortholog
    MAPK8IP1, mitogen-activated protein kinase 8 interacting protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAPK8IP1, mitogen-activated protein kinase 8 interacting protein 1
  • Synonyms
    IB1, JIP-1, JIP1, PRKM8IP
  • Links
    NCBI Gene ID: 9479
    neXtProt AC: NX_Q9UQF2
    UniProt: Q9UQF2

  • Chr Location
    11p11.2; chr11:45885651-45906465 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human MAPK8IP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 5 alleles in 5 genetic backgrounds
    12 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in a decreased susceptibility to ischemic brain injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19099 NCBI Gene Model | MGI Sequence Detail 17588 C57BL/6J ±  kb
    transcript NM_001202445 RefSeq | MGI Sequence Detail 3246 C57BL/6  
    polypeptide Q9WVI9 UniProt | EBI | MGI Sequence Detail 707 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 42
      Primer pair 3
      Other 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 16
      Gene Ontology 19
      Phenotypes 28
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:347592 Fei Q, et al., Timing dependent neuronal migration is regulated by Cdk5-mediated phosphorylation of JIP1. Front Cell Dev Biol. 2024;12:1371568

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/24/2024
    MGI 6.24
    The Jackson Laboratory