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Ifnar2 Gene Detail
Summary
  • Symbol
    Ifnar2
  • Name
    interferon (alpha and beta) receptor 2
  • Synonyms
    Ifnar-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098243
    NCBI Gene: 15976
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:91169671-91202477 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 52.82 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    809 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098243
 protein coding gene Chr16:91166517-91202477 (+)
129S1/SvImJ ENSMUSG00200036849
 protein coding gene Chr16:88093259-88126069 (+)
A/J ENSMUSG00195026328
 protein coding gene Chr16:87847644-87880458 (+)
AKR/J ENSMUSG00220015848
 protein coding gene Chr16:88043761-88076579 (+)
BALB/cJ ENSMUSG00180014043
 protein coding gene Chr16:87920975-87953785 (+)
C3H/HeJ ENSMUSG00175015693
 protein coding gene Chr16:88258294-88291107 (+)
C57BL/6NJ ENSMUSG00215029374
 protein coding gene Chr16:88057955-88090763 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020957
 protein coding gene Chr16:85762281-85793696 (+)
CAST/EiJ ENSTCUG00005018206
 protein coding gene Chr16:87594844-87628075 (+)
CBA/J ENSMUSG00210036243
 protein coding gene Chr16:88152776-88185235 (+)
DBA/2J ENSMUSG00185033977
 protein coding gene Chr16:88108942-88141752 (+)
FVB/NJ ENSMUSG00205021913
 protein coding gene Chr16:87880746-87913566 (+)
JF1/MsJ ENSUMUG00000035358
 protein coding gene Chr16:88240856-88273317 (+)
LP/J ENSMUSG00230033389
 protein coding gene Chr16:90640050-90672858 (+)
NOD/ShiLtJ ENSMUSG00190022657
 protein coding gene Chr16:88082837-88115643 (+)
NZO/HlLtJ ENSMUSG00225029589
 protein coding gene Chr16:93755506-93788321 (+)
PWK/PhJ ENSLUMG00010012160
 protein coding gene Chr16:87876281-87909417 (+)
SPRET/EiJ ENSMSPG00010025735
 protein coding gene Chr16:89025442-89057656 (+)
WSB/EiJ ENSIUOG00005018424
 protein coding gene Chr16:87987877-88020825 (+)



Homology
more
  • Human Ortholog
    IFNAR2, interferon alpha and beta receptor subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFNAR2, interferon alpha and beta receptor subunit 2
  • Synonyms
    IFNABR, IFN-alpha-REC, IFNARB, IFN-R, IFN-R-2, IMD45
  • Links
    NCBI Gene ID: 3455
    UniProt: P48551

  • Chr Location
    21q22.11; chr21:33205282-33265675 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human IFNAR2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    121 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with mutations of this gene have defects in immune responses involving, variously, NK cells, CD4+ and CD8+ T cells and B cells in response to induced and transplanted tumors, viruses, and double stranded DNA. These defects include diminished secretion of type I and type II interferons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    853
  • Tissues
    176
  • cDNA Data
    75
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022971 Ensembl Gene Model | MGI Sequence Detail 32807 C57BL/6J ±  kb
    transcript ENSMUST00000023693 Ensembl | MGI Sequence Detail 3047 Not Applicable  
    polypeptide ENSMUSP00000023693 Ensembl | MGI Sequence Detail 513 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 78
      cDNA 75
      Primer pair 2
      Other 1
      Antibodies 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2146482
    References
    more
    • Summaries
      All 196
      Developmental Gene Expression 8
      Diseases 4
      Gene Ontology 9
      Phenotypes 121
    • Earliest
      J:39777 Pfeffer LM, et al., The short form of the interferon alpha/beta receptor chain 2 acts as a dominant negative for type I interferon action. J Biol Chem. 1997 Apr 25;272(17):11002-5
    • Latest
      J:385727 Harada K, et al., Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome. Immunology. 2026 Mar;177(3):596-612
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/01/2026
    MGI 6.24     		The Jackson Laboratory