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Jarid2 Gene Detail
Summary
  • Symbol
    Jarid2
  • Name
    jumonji and AT-rich interaction domain containing 2
  • Synonyms
    Jmj, jumonji
  • Feature Type
    protein coding gene
  • IDs
    MGI:104813
    NCBI Gene: 16468
  • Alliance
    genome feature page
  • Transcription Start Sites
    35 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:44882950-45075119 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 21.66 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3502 from dbSNP Build 142
  • Strain Annotations
    31
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104813
 protein coding gene Chr13:44881817-45075119 (+)
129S1/SvImJ ENSMUSG00200035287
 protein coding gene Chr13:42247298-42329351 (+)
129S1/SvImJ ENSMUSGG00200054733
 protein coding gene Chr13:42138848-42230108 (+)
A/J ENSMUSG00195028199
 protein coding gene Chr13:41307404-41389474 (+)
A/J ENSMUSGG00195055351
 protein coding gene Chr13:41198931-41290206 (+)
AKR/J ENSMUSG00220008491
 protein coding gene Chr13:41109521-41191591 (+)
AKR/J ENSMUSGG00220054351
 protein coding gene Chr13:41001025-41092353 (+)
BALB/cJ ENSMUSG00180008061
 protein coding gene Chr13:41613978-41696032 (+)
BALB/cJ ENSMUSGG00180055469
 protein coding gene Chr13:41505521-41596791 (+)
C3H/HeJ ENSMUSGG00175054964
 protein coding gene Chr13:41469830-41561095 (+)
C3H/HeJ ENSMUSG00175027194
 protein coding gene Chr13:41578291-41660340 (+)
C57BL/6NJ ENSMUSG00215004870
 protein coding gene Chr13:41737881-41819925 (+)
C57BL/6NJ ENSMUSGG00215055650
 protein coding gene Chr13:41628894-41720716 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018474
 protein coding gene Chr13:39989849-40177451 (+)
CAST/EiJ ENSTCUG00005030577
 protein coding gene Chr13:41638456-41712180 (+)
CBA/J ENSMUSGG00210054859
 protein coding gene Chr13:41475406-41566674 (+)
CBA/J ENSMUSG00210026337
 protein coding gene Chr13:41583862-41665897 (+)
DBA/2J ENSMUSGG00185057671
 protein coding gene Chr13:42284018-42375794 (+)
DBA/2J ENSMUSG00185029650
 protein coding gene Chr13:42392962-42475005 (+)
FVB/NJ ENSMUSGG00205054368
 protein coding gene Chr13:41227238-41318533 (+)
FVB/NJ ENSMUSG00205010752
 protein coding gene Chr13:41335727-41417789 (+)
JF1/MsJ ENSUMUG00000011723
 protein coding gene Chr13:41928878-42011423 (+)
LP/J ENSMUSG00230025866
 protein coding gene Chr13:51716171-51798214 (+)
LP/J ENSMUSGG00230055783
 protein coding gene Chr13:51607709-51698978 (+)
NOD/ShiLtJ ENSMUSG00190011714
 protein coding gene Chr13:41791898-41873943 (+)
NOD/ShiLtJ ENSMUSGG00190054547
 protein coding gene Chr13:41682944-41774729 (+)
NZO/HlLtJ ENSMUSGG00225055452
 protein coding gene Chr13:45375625-45466206 (+)
NZO/HlLtJ ENSMUSG00225036077
 protein coding gene Chr13:45483355-45565314 (+)
PWK/PhJ ENSLUMG00010020016
 protein coding gene Chr13:40771327-40853382 (+)
SPRET/EiJ ENSMSPG00010026949
 protein coding gene Chr13:40745313-40925619 (+)
WSB/EiJ ENSIUOG00005025621
 protein coding gene Chr13:40919745-41001709 (+)



Homology
more
  • Human Ortholog
    JARID2, jumonji and AT-rich interaction domain containing 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    JARID2, jumonji and AT-rich interaction domain containing 2
  • Synonyms
    DIDDF, JMJ
  • Links
    NCBI Gene ID: 3720
    UniProt: Q92833

  • Chr Location
    6p22.3; chr6:15244937-15522042 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human JARID2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    71 phenotypes from 7 alleles in 9 genetic backgrounds
    3 phenotypes from multigenic genotypes
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants show strain-specific phenotypes, including embryonic death and defective neural tube closure, impaired hematopoiesis and hypoplasia of liver, thymus and spleen. Homozygotes for another mutation die at birth with cardiac defects. Homozygous expression of the methylation-blocking p.K116R mutation is not viable, but in embryos leads to homeotic transformation of vertebrae and extra vertebrae.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    891
  • Tissues
    193
  • cDNA Data
    25
  • Literature Summary
    39
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038518 Ensembl Gene Model | MGI Sequence Detail 192170 C57BL/6J ±  kb
    transcript ENSMUST00000173704 Ensembl | MGI Sequence Detail 4135 Not Applicable  
    polypeptide ENSMUSP00000134675 Ensembl | MGI Sequence Detail 1234 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 1
      cDNA 26
      Primer pair 8
      Other 1
      Antibodies 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-28107, MGI:2139495, MGI:2145204, MGI:2145380, MGI:2145512
    References
    more
    • Summaries
      All 144
      Developmental Gene Expression 39
      Gene Ontology 25
      Phenotypes 56
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:383110 Agius SC, et al., Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains. Mol Cell. 2026 Mar 19;86(6):1032-1045.e10
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory