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Pon1 Gene Detail
Summary
  • Symbol
    Pon1
  • Name
    paraoxonase 1
  • Synonyms
    Pon
  • Feature Type
    protein coding gene
  • IDs
    MGI:103295
    NCBI Gene: 18979
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:5168101-5193824 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 1.99 cM, cytoband A2
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103295
 protein coding gene Chr6:5168090-5193946 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030432
 protein coding gene Chr6:1992680-2021042 (-)
A/J MGP_AJ_G0030405
 protein coding gene Chr6:1917221-1943403 (-)
AKR/J MGP_AKRJ_G0030332
 protein coding gene Chr6:1967963-1997266 (-)
BALB/cJ MGP_BALBcJ_G0030414
 protein coding gene Chr6:1893683-1920177 (-)
C3H/HeJ MGP_C3HHeJ_G0030128
 protein coding gene Chr6:1944444-1970201 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030869
 protein coding gene Chr6:2056672-2085271 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028080
 protein coding gene Chr6:1645678-1670671 (-)
CAST/EiJ MGP_CASTEiJ_G0029529
 protein coding gene Chr6:1942305-1967840 (-)
CBA/J MGP_CBAJ_G0030106
 protein coding gene Chr6:2097806-2129940 (-)
DBA/2J MGP_DBA2J_G0030250
 protein coding gene Chr6:1873795-1899277 (-)
FVB/NJ MGP_FVBNJ_G0030204
 protein coding gene Chr6:1884066-1909483 (-)
LP/J MGP_LPJ_G0030337
 protein coding gene Chr6:1953148-1978733 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030240
 protein coding gene Chr6:2183287-2209222 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030899
 protein coding gene Chr6:1927892-1953418 (-)
PWK/PhJ MGP_PWKPhJ_G0029244
 protein coding gene Chr6:1818705-1845412 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029080
 protein coding gene Chr6:1987689-2013285 (-)
WSB/EiJ MGP_WSBEiJ_G0029606
 protein coding gene Chr6:1925166-1954569 (-)



Homology
more
  • Human Ortholog
    PON1, paraoxonase 1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PON1, paraoxonase 1
  • Synonyms
    ESA, MVCD5, PON
  • Links
    NCBI Gene ID: 5444
    neXtProt AC: NX_P27169
    UniProt: P27169

  • Chr Location
    7q21.3; chr7:95297676-95324532 (-)  GRCh38
Human Diseases
more
  • Diseases
    29 with human PON1 associations

Human Disease Mouse Models
      
IDs
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in increased susceptibility to organophosphate toxicity and atherosclerosis when fed a high-fat/cholesterol diet. Females exhibit increased LDL and VLD cholesterol levels. Macrophages show increased oxidative stress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    858
  • Tissues
    142
  • cDNA Data
    62
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18979 NCBI Gene Model | MGI Sequence Detail 25724 C57BL/6J ±  kb
    transcript NM_001410259 RefSeq | MGI Sequence Detail 1563 ZRU/MplStud  
    polypeptide P52430 UniProt | EBI | MGI Sequence Detail 355 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      Genomic 3
      cDNA 63
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24177, MGD-MRK-37426, MGI:108386
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 14
      Gene Ontology 9
      Phenotypes 23
    • Earliest
      J:28139 Sorenson RC, et al., Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase. Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7187-91
    • Latest
      J:296562 Kofman O, et al., Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults. PLoS One. 2020;15(9):e0239738
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory