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Gc Gene Detail
Summary
  • Symbol
    Gc
  • Name
    vitamin D binding protein
  • Synonyms
    DBP, vitamin D binding protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:95669
    NCBI Gene: 14473
  • Alliance
    genome feature page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:89565381-89605757 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 44.32 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1175 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95669
 protein coding gene Chr5:89565370-89605757 (-)
129S1/SvImJ ENSMUSG00200007916
 protein coding gene Chr5:85287371-85320943 (-)
A/J ENSMUSG00195025277
 protein coding gene Chr5:84467676-84508058 (-)
AKR/J ENSMUSG00220011051
 protein coding gene Chr5:84610914-84651289 (-)
BALB/cJ ENSMUSG00180024202
 protein coding gene Chr5:84304152-84344185 (-)
C3H/HeJ ENSMUSG00175041411
 protein coding gene Chr5:86399445-86439484 (-)
C57BL/6NJ ENSMUSG00215029614
 protein coding gene Chr5:85160586-85200968 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027381
 protein coding gene Chr5:82648304-82685004 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210005795
 protein coding gene Chr5:85199332-85239381 (-)
DBA/2J ENSMUSG00185036536
 protein coding gene Chr5:87113733-87153441 (-)
FVB/NJ ENSMUSG00205016857
 protein coding gene Chr5:83998567-84041758 (-)
JF1/MsJ ENSUMUG00000025962
 protein coding gene Chr5:91423692-91457399 (-)
LP/J ENSMUSG00230024667
 protein coding gene Chr5:91813808-91847364 (-)
NOD/ShiLtJ ENSMUSG00190028884
 protein coding gene Chr5:84067636-84107670 (-)
NZO/HlLtJ ENSMUSG00225008223
 protein coding gene Chr5:96962140-96995629 (-)
PWK/PhJ ENSLUMG00010027227
 protein coding gene Chr5:84085108-84119055 (-)
SPRET/EiJ ENSMSPG00010034811
 protein coding gene Chr5:86501273-86527625 (-)
WSB/EiJ ENSIUOG00005025820
 protein coding gene Chr5:87106956-87146974 (-)



Homology
more
  • Human Ortholog
    GC, GC vitamin D binding protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GC, GC vitamin D binding protein
  • Synonyms
    DBP, DBP/GC, DBP-maf, Gc-MAF, GcMAF, GRD3, HEL-S-51, VDB, VDBG, VDBP
  • Links
    NCBI Gene ID: 2638
    UniProt: P02774

  • Chr Location
    4q13.3; chr4:71735436-71805527 (-)  GRCh38
  • MGI Vertebrate Homology
    Gc stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: GC
  • Gene Tree
    Gc
Human Diseases
more
  • Diseases
    13 with human GC associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene show an essentially normal phenotype. However, they have an increased sensitivity to vitamin D deficiency in the diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    634
  • Tissues
    16
  • cDNA Data
    190
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035540 Ensembl Gene Model | MGI Sequence Detail 40377 C57BL/6J ±  kb
    transcript ENSMUST00000049209 Ensembl | MGI Sequence Detail 1801 Not Applicable  
    polypeptide ENSMUSP00000046636 Ensembl | MGI Sequence Detail 476 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 197
      Genomic 2
      cDNA 192
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10014
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 27
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:391189 Qin LN, et al., Vitamin D binding protein (VDBP) hijacks twist1 to inhibit vasculogenic mimicry in hepatocellular carcinoma. Theranostics. 2024;14(1):436-450
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory