About   Help   FAQ
Slc6a3 Gene Detail
Summary
  • Symbol
    Slc6a3
  • Name
    solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
  • Synonyms
    DAT, Dat1
  • Feature Type
    protein coding gene
  • IDs
    MGI:94862
    NCBI Gene: 13162
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:73684866-73726791 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 40.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1370 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94862
 protein coding gene Chr13:73684270-73726791 (+)
129S1/SvImJ ENSMUSG00200010112
 protein coding gene Chr13:68076058-68117980 (+)
A/J ENSMUSG00195026709
 protein coding gene Chr13:68664038-68705974 (+)
AKR/J ENSMUSG00220031980
 protein coding gene Chr13:67258401-67300319 (+)
BALB/cJ ENSMUSG00180020171
 protein coding gene Chr13:69162413-69204347 (+)
C3H/HeJ ENSMUSG00175007473
 protein coding gene Chr13:69443940-69485866 (+)
C57BL/6NJ ENSMUSG00215006596
 protein coding gene Chr13:69228407-69270344 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018703
 protein coding gene Chr13:68176924-68216378 (+)
CAST/EiJ ENSTCUG00005011620
 protein coding gene Chr13:68750604-68792626 (+)
CBA/J ENSMUSG00210008594
 protein coding gene Chr13:68763738-68805670 (+)
DBA/2J ENSMUSG00185017726
 protein coding gene Chr13:72455289-72497214 (+)
FVB/NJ ENSMUSG00205019172
 protein coding gene Chr13:68142660-68184592 (+)
JF1/MsJ ENSUMUG00000021664
 protein coding gene Chr13:72221304-72263334 (+)
LP/J ENSMUSG00230024968
 protein coding gene Chr13:82377240-82418918 (+)
NOD/ShiLtJ ENSMUSG00190026890
 protein coding gene Chr13:68763979-68805814 (+)
NZO/HlLtJ ENSMUSG00225027764
 protein coding gene Chr13:74881263-74923185 (+)
PWK/PhJ ENSLUMG00010011069
 protein coding gene Chr13:68256192-68298229 (+)
SPRET/EiJ ENSMSPG00010029524
 protein coding gene Chr13:69145023-69182509 (+)
WSB/EiJ ENSIUOG00005019067
 protein coding gene Chr13:68020396-68062117 (+)



Homology
more
  • Human Ortholog
    SLC6A3, solute carrier family 6 member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC6A3, solute carrier family 6 member 3
  • Synonyms
    DAT, DAT1, PKDYS, PKDYS1
  • Links
    NCBI Gene ID: 6531
    UniProt: Q01959

  • Chr Location
    5p15.33; chr5:1392794-1445514 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with Slc6a3 mouse models; 5 with human SLC6A3 associations

Human Disease Mouse Models
      
IDs
 View 4 models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    8 with disease annotations
  • References
    12 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    66 phenotypes from 14 alleles in 17 genetic backgrounds
    104 phenotypes from multigenic genotypes
    3 images
    976 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit dwarfism, hyperactivity (especially in a novel environment), 5-fold higher extracellular dopamine levels, impaired spatial cognitive function, anterior pituitary hypoplasia, and failure to lactate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    103
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    909
  • Tissues
    164
  • cDNA Data
    11
  • Literature Summary
    84
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021609 Ensembl Gene Model | MGI Sequence Detail 41926 C57BL/6J ±  kb
    transcript ENSMUST00000022100 Ensembl | MGI Sequence Detail 3456 Not Applicable  
    polypeptide ENSMUSP00000022100 Ensembl | MGI Sequence Detail 619 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000015188 sodium-dependent dopamine transporter
      (term hierarchy)
    • InterPro Domains
      IPR000175 Sodium:neurotransmitter symporter
      IPR002436 Sodium:neurotransmitter symporter, dopamine
      IPR037272 Sodium:neurotransmitter symporter superfamily
    • GlyGen
      Q61327 5 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 14
      Primer pair 2
      Other 4
      Antibodies 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-8798
    References
    more
    • Summaries
      All 1129
      Developmental Gene Expression 84
      Diseases 12
      Gene Ontology 25
      Phenotypes 976
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:391275 Jin S, et al., Status-dependent competition engagement via mesocortical pathway. Neuron. 2026 Aug 12;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory