Slc6a3^tm1Rbl
Targeted Allele Detail

Summary

• Symbol: Slc6a3^tm1Rbl
• Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 1, Randy D Blakely
• MGI ID: MGI:5643943
• Synonyms: DAT Val559
• Gene: Slc6a3 Location: Chr13:73684866-73726791 bp, + strand Genetic Position: Chr13, 40.1 cM
• Alliance: Slc6a3^tm1Rbl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221936
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Humanized sequence, Modified isoform(s))
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A valine for alanine substitution at amino acid 559 (A559V, equivalent to that found in ADHD probands) was introduced in exon 13, along with a self-excising loxP-flanked cre recombinase and neomycin resistance cassettes in the 3 intron. (J:221936)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc6a3 Mutation: 66 strains or lines available

References

• Original: J:221936 Mergy MA, et al., Genetic targeting of the amphetamine and methylphenidate-sensitive dopamine transporter: on the path to an animal model of attention-deficit hyperactivity disorder. Neurochem Int. 2014 Jul;73:56-70
• All: 5 reference(s)