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Defb3 Gene Detail
Summary
  • Symbol
    Defb3
  • Name
    defensin beta 3
  • Synonyms
    mBD-3
Location &
Maps
more
  • Sequence Map
    Chr8:19343376-19345307 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 10.35 cM, cytoband A4
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    226 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351612
 protein coding gene Chr8:19343376-19345355 (+)
129S1/SvImJ ENSMUSG00200029198
 protein coding gene Chr8:16146025-16147969 (+)
A/J ENSMUSG00195038479
 protein coding gene Chr8:16569104-16571048 (+)
AKR/J ENSMUSG00220030720
 protein coding gene Chr8:16341467-16343398 (+)
BALB/cJ ENSMUSG00180020821
 protein coding gene Chr8:16189457-16191403 (+)
C3H/HeJ ENSMUSG00175036837
 protein coding gene Chr8:16367507-16369451 (+)
C57BL/6NJ ENSMUSG00215023782
 protein coding gene Chr8:16313496-16315427 (+)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005018110
 protein coding gene Chr8:16144079-16146006 (+)
CBA/J ENSMUSG00210041612
 protein coding gene Chr8:16206342-16208286 (+)
DBA/2J ENSMUSG00185006548
 protein coding gene Chr8:16334151-16336095 (+)
FVB/NJ ENSMUSG00205023661
 protein coding gene Chr8:16215635-16217579 (+)
JF1/MsJ ENSUMUG00000031309
 protein coding gene Chr8:16246460-16248387 (+)
LP/J ENSMUSG00230019358
 protein coding gene Chr8:18421985-18423916 (+)
NOD/ShiLtJ ENSMUSG00190028924
 protein coding gene Chr8:16338592-16340536 (+)
NZO/HlLtJ ENSMUSG00225041628
 protein coding gene Chr8:26276904-26278835 (+)
PWK/PhJ ENSLUMG00010026084
 protein coding gene Chr8:16216438-16218384 (+)
SPRET/EiJ ENSMSPG00010013166
 protein coding gene Chr8:16448499-16450394 (+)
WSB/EiJ ENSIUOG00005018494
 protein coding gene Chr8:16283313-16285244 (+)



Homology
more
  • Human Ortholog
    DEFB4A, defensin beta 4A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEFB4A, defensin beta 4A
  • Synonyms
    BD-2, DEFB102, DEFB-2, DEFB2, DEFB4, HBD-2, SAP1
  • Links
    NCBI Gene ID: 1673
    UniProt: O15263

  • Chr Location
    8p23.1
  • Human Ortholog
    DEFB4B, defensin beta 4B
  • Synonyms
    DEFB4P
  • Links
    NCBI Gene ID: 100289462

  • Chr Location
    8
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibits increased susceptibility to P. aeruginosa- or F. solani-induced keratitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    603
  • Tissues
    3
  • cDNA Data
    4
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039775 Ensembl Gene Model | MGI Sequence Detail 1932 C57BL/6J ±  kb
    transcript ENSMUST00000033852 Ensembl | MGI Sequence Detail 275 Not Applicable  
    polypeptide ENSMUSP00000033852 Ensembl | MGI Sequence Detail 63 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      Genomic 4
      cDNA 4
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:55859 Bals R, et al., Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs. Infect Immun. 1999 Jul;67(7):3542-7
    • Latest
      J:341717 Taylor TC, et al., IkappaBzeta is an essential mediator of immunity to oropharyngeal candidiasis. Cell Host Microbe. 2023 Oct 11;31(10):1700-1713.e4
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory