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Matn3 Gene Detail
Summary
  • Symbol
    Matn3
  • Name
    matrilin 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1328350
    NCBI Gene: 17182
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:8997929-9022028 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 3.96 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    720 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1328350
 protein coding gene Chr12:8997929-9022028 (+)
129S1/SvImJ ENSMUSG00200023668
 protein coding gene Chr12:5968965-5993136 (+)
A/J ENSMUSG00195015561
 protein coding gene Chr12:6017939-6042134 (+)
AKR/J ENSMUSG00220025954
 protein coding gene Chr12:6046367-6070544 (+)
BALB/cJ ENSMUSG00180014592
 protein coding gene Chr12:6010486-6034662 (+)
C3H/HeJ ENSMUSG00175009503
 protein coding gene Chr12:5999148-6023332 (+)
C57BL/6NJ ENSMUSG00215012151
 protein coding gene Chr12:5833687-5857876 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017606
 protein coding gene Chr12:5668742-5690175 (+)
CAST/EiJ ENSTCUG00005020666
 protein coding gene Chr12:5690864-5714532 (+)
CBA/J ENSMUSG00210013075
 protein coding gene Chr12:6029888-6054069 (+)
DBA/2J ENSMUSG00185019747
 protein coding gene Chr12:5972707-5996880 (+)
FVB/NJ ENSMUSG00205002984
 protein coding gene Chr12:5729331-5753509 (+)
JF1/MsJ ENSUMUG00000015962
 protein coding gene Chr12:5925224-5948025 (+)
LP/J ENSMUSG00230011445
 protein coding gene Chr12:7802627-7826801 (+)
NOD/ShiLtJ ENSMUSG00190007879
 protein coding gene Chr12:7216888-7241059 (+)
NZO/HlLtJ ENSMUSG00225017363
 protein coding gene Chr12:9881865-9906036 (+)
PWK/PhJ ENSLUMG00010016910
 protein coding gene Chr12:5662786-5685028 (+)
SPRET/EiJ ENSMSPG00010004849
 protein coding gene Chr12:6276370-6296893 (+)
WSB/EiJ ENSIUOG00005002228
 protein coding gene Chr12:6005480-6030050 (+)



Homology
more
  • Human Ortholog
    MATN3, matrilin 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MATN3, matrilin 3
  • Synonyms
    DIPOA, EDM5, HOA, OADIP, OS2, SEMDBCD
  • Links
    NCBI Gene ID: 4148
    UniProt: O15232

  • Chr Location
    2p24.1; chr2:19992052-20012669 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Matn3 mouse models; 3 with human MATN3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    789
  • Tissues
    46
  • cDNA Data
    11
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17182 NCBI Gene Model | MGI Sequence Detail 24100 C57BL/6J ±  kb
    transcript NM_010770 RefSeq | MGI Sequence Detail 3014 ZRU/MplStud  
    polypeptide O35701 UniProt | EBI | MGI Sequence Detail 481 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 12
      Primer pair 1
      Antibodies 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2144975
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 16
      Diseases 2
      Gene Ontology 12
      Phenotypes 20
    • Earliest
      J:51112 Wagener R, et al., Primary structure of matrilin-3, a new member of a family of extracellular matrix proteins related to cartilage matrix protein (matrilin-1) and von Willebrand factor. FEBS Lett. 1997 Aug 11;413(1):129-34
    • Latest
      J:348599 Zhou X, et al., Matrilin-3 supports neuroprotection in ischemic stroke by suppressing astrocyte-mediated neuroinflammation. Cell Rep. 2024 Mar 21;43(4):113980
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory