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Nat2 Gene Detail
Summary
  • Symbol
    Nat2
  • Name
    N-acetyltransferase 2 (arylamine N-acetyltransferase)
  • Feature Type
    protein coding gene
  • IDs
    MGI:109201
    NCBI Gene: 17961
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:67947510-67955236 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 33.38 cM, cytoband B3.1
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    378 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109201
 protein coding gene Chr8:67947510-67955296 (+)
129S1/SvImJ ENSMUSG00200029221
 protein coding gene Chr8:62791613-62799339 (+)
A/J ENSMUSG00195016283
 protein coding gene Chr8:63193838-63201564 (+)
AKR/J ENSMUSG00220024583
 protein coding gene Chr8:63010956-63018680 (+)
BALB/cJ ENSMUSG00180025972
 protein coding gene Chr8:62766150-62773876 (+)
C3H/HeJ ENSMUSG00175018966
 protein coding gene Chr8:63008995-63016719 (+)
C57BL/6NJ ENSMUSG00215030674
 protein coding gene Chr8:62773215-62780941 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031099
 protein coding gene Chr8:59799135-59806842 (+)
CAST/EiJ ENSTCUG00005030568
 protein coding gene Chr8:62548927-62556650 (+)
CBA/J ENSMUSG00210029004
 protein coding gene Chr8:62892602-62900326 (+)
DBA/2J ENSMUSG00185022290
 protein coding gene Chr8:68940807-68948531 (+)
FVB/NJ ENSMUSG00205031572
 protein coding gene Chr8:62334355-62342081 (+)
JF1/MsJ ENSUMUG00000013861
 protein coding gene Chr8:71206748-71216147 (+)
LP/J ENSMUSG00230032363
 protein coding gene Chr8:72583140-72590866 (+)
NOD/ShiLtJ ENSMUSG00190019777
 protein coding gene Chr8:62809419-62817145 (+)
NZO/HlLtJ ENSMUSG00225047592
 protein coding gene Chr8:76014887-76022611 (+)
PWK/PhJ ENSLUMG00010030569
 protein coding gene Chr8:62689916-62697643 (+)
SPRET/EiJ ENSMSPG00010038335
 protein coding gene Chr8:64012039-64019699 (+)
WSB/EiJ ENSIUOG00005024261
 protein coding gene Chr8:63637658-63645378 (+)



Homology
more
  • Human Ortholog
    NAT1, N-acetyltransferase 1
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NAT1, N-acetyltransferase 1
  • Synonyms
    AAC1, MNAT, NAT-1, NATI
  • Links
    NCBI Gene ID: 9
    UniProt: P18440

  • Chr Location
    8p22; chr8:18170399-18223739 (+)  GRCh38
  • Human Ortholog
    NAT2, N-acetyltransferase 2
  • Synonyms
    AAC2, NAT-2, PNAT
  • Links
    NCBI Gene ID: 10
    UniProt: P11245

  • Chr Location
    8p22; chr8:18386301-18401218 (+)  GRCh38
Human Diseases
more
  • Diseases
    29 with human NAT1,NAT2 associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 5 genetic backgrounds
    2 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this gene does not result in an overt phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    16
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    871
  • Tissues
    190
  • cDNA Data
    13
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051147 Ensembl Gene Model | MGI Sequence Detail 7727 C57BL/6J ±  kb
    transcript ENSMUST00000163856 Ensembl | MGI Sequence Detail 1463 Not Applicable  
    polypeptide ENSMUSP00000130065 Ensembl | MGI Sequence Detail 290 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 7
      cDNA 13
      Primer pair 1
      Antibodies 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-38245, MGI:2142742
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 7
      Gene Ontology 12
      Phenotypes 23
    • Earliest
      J:8150 Ebihara S, et al., Genetic control of melatonin synthesis in the pineal gland of the mouse. Science. 1986 Jan 31;231(4737):491-3
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory