Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ZMPSTE24
  • Mouse genes Zmpste24
  • Rat genes Zmpste24
  • Zfish genes zmpste24
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Zmpste24

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003690	double-stranded DNA binding	Zmpste24	IGI	MGI:MGI:1347476	Mouse	PMID:23117660
Molecular Function	GO:0004175	endopeptidase activity	Zmpste24	IDA		Mouse	PMID:17652517
Molecular Function	GO:0004222	metalloendopeptidase activity	Zmpste24	IMP		Mouse	MGI:MGI:2388414|PMID:12235369
Molecular Function	GO:0004222	metalloendopeptidase activity	Zmpste24	IDA		Mouse	MGI:MGI:5796042|PMID:27462105
Molecular Function	GO:0004222	metalloendopeptidase activity	Zmpste24	IMP	MGI:MGI:2158363	Mouse	PMID:11399759
Molecular Function	GO:0004222	metalloendopeptidase activity	Zmpste24	IDA		Mouse	PMID:11399759
Molecular Function	GO:0005515	protein binding	ZMPSTE24	IPI	UniProtKB:P02545-1	Human	PMID:23539603
Molecular Function	GO:0005515	protein binding	ZMPSTE24	IPI	UniProtKB:C5E519	Human	PMID:28169297
Molecular Function	GO:0005515	protein binding	ZMPSTE24	IPI	UniProtKB:P06821	Human	PMID:28169297
Molecular Function	GO:0005515	protein binding	ZMPSTE24	IPI	UniProtKB:Q20MH8	Human	PMID:28169297
Cellular Component	GO:0070062	extracellular exosome	ZMPSTE24	HDA		Human	PMID:19056867
Cellular Component	GO:0016020	membrane	ZMPSTE24	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Zmpste24	IDA		Mouse	PMID:11399759
Cellular Component	GO:0005635	nuclear envelope	Zmpste24	IDA		Mouse	PMID:15980864
Cellular Component	GO:0032991	protein-containing complex	ZMPSTE24	IDA		Human	PMID:28246125
Biological Process	GO:0007628	adult walking behavior	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:11923874
Biological Process	GO:0030282	bone mineralization	Zmpste24	IGI	MGI:MGI:1888594	Mouse	PMID:23686339
Biological Process	GO:1990036	calcium ion import into sarcoplasmic reticulum	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:27799555
Biological Process	GO:0061762	CAMKK-AMPK signaling cascade	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:18443001
Biological Process	GO:0061337	cardiac conduction	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:27799555
Biological Process	GO:0055013	cardiac muscle cell development	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:11923874
Biological Process	GO:0003231	cardiac ventricle development	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:11923874
Biological Process	GO:0044255	cellular lipid metabolic process	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:11923874
Biological Process	GO:0071480	cellular response to gamma radiation	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:15980864
Biological Process	GO:0006325	chromatin organization	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:16079796
Biological Process	GO:0006325	chromatin organization	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:20961378
Biological Process	GO:0051276	chromosome organization	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:15980864
Biological Process	GO:0008340	determination of adult lifespan	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:16079796
Biological Process	GO:0008340	determination of adult lifespan	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:18443001
Biological Process	GO:0008340	determination of adult lifespan	Zmpste24	IGI	MGI:MGI:1099440	Mouse	PMID:23695662
Biological Process	GO:0008340	determination of adult lifespan	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:11923874
Biological Process	GO:0008340	determination of adult lifespan	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:21746928
Biological Process	GO:0008340	determination of adult lifespan	Zmpste24	IGI	MGI:MGI:1931221	Mouse	PMID:21746928
Biological Process	GO:0008340	determination of adult lifespan	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:27799555
Biological Process	GO:0008340	determination of adult lifespan	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:15980864
Biological Process	GO:0008340	determination of adult lifespan	Zmpste24	IGI	MGI:MGI:1888594	Mouse	PMID:23686339
Biological Process	GO:0006974	DNA damage response	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:16079796
Biological Process	GO:0006974	DNA damage response	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:21522133
Biological Process	GO:0006974	DNA damage response	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:15980864
Biological Process	GO:0006281	DNA repair	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:15980864
Biological Process	GO:0006281	DNA repair	Zmpste24	IGI	MGI:MGI:1931221	Mouse	PMID:21746928
Biological Process	GO:0006281	DNA repair	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:21746928
Biological Process	GO:0008544	epidermis development	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:11923874
Biological Process	GO:0003417	growth plate cartilage development	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:11923874
Biological Process	GO:0001942	hair follicle development	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:11923874
Biological Process	GO:0003007	heart morphogenesis	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:11923874
Biological Process	GO:0006925	inflammatory cell apoptotic process	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:11923874
Biological Process	GO:0060993	kidney morphogenesis	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:11923874
Biological Process	GO:0001889	liver development	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:23117660
Biological Process	GO:0043007	maintenance of rDNA	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:20961378
Biological Process	GO:0035264	multicellular organism growth	Zmpste24	IGI	MGI:MGI:1888594	Mouse	PMID:23686339
Biological Process	GO:0035264	multicellular organism growth	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:11923874
Biological Process	GO:0010629	negative regulation of gene expression	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:23117660
Biological Process	GO:0010629	negative regulation of gene expression	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:16079796
Biological Process	GO:1903799	negative regulation of miRNA processing	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:21522133
Biological Process	GO:1903799	negative regulation of miRNA processing	Zmpste24	IGI	MGI:MGI:98834	Mouse	PMID:21522133
Biological Process	GO:0050905	neuromuscular process	Zmpste24	IGI	MGI:MGI:1888594	Mouse	PMID:23686339
Biological Process	GO:0050905	neuromuscular process	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:11923874
Biological Process	GO:0006998	nuclear envelope organization	Zmpste24	IMP		Mouse	MGI:MGI:2388414|PMID:12235369
Biological Process	GO:0006998	nuclear envelope organization	Zmpste24	IDA		Mouse	MGI:MGI:5796042|PMID:27462105
Biological Process	GO:0006998	nuclear envelope organization	Zmpste24	IDA		Mouse	MGI:MGI:3719516|PMID:17652517
Biological Process	GO:0006998	nuclear envelope organization	Zmpste24	IGI	MGI:MGI:96794	Mouse	PMID:15608054
Biological Process	GO:0006998	nuclear envelope organization	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:11923874
Biological Process	GO:0006998	nuclear envelope organization	Zmpste24	IMP	MGI:MGI:2158363	Mouse	PMID:15608054
Biological Process	GO:0006998	nuclear envelope organization	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:20961378
Biological Process	GO:0006997	nucleus organization	Zmpste24	IGI	MGI:MGI:96794	Mouse	PMID:16511604
Biological Process	GO:0006997	nucleus organization	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:11923874
Biological Process	GO:0006997	nucleus organization	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:16079796
Biological Process	GO:0010628	positive regulation of gene expression	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:27498005
Biological Process	GO:0044029	positive regulation of gene expression via CpG island demethylation	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:20961378
Biological Process	GO:0030327	prenylated protein catabolic process	Zmpste24	IDA		Mouse	PMID:11399759
Biological Process	GO:0051604	protein maturation	Zmpste24	IDA		Mouse	MGI:MGI:3719516|PMID:17652517
Biological Process	GO:0051604	protein maturation	Zmpste24	IMP		Mouse	MGI:MGI:2388414|PMID:12235369
Biological Process	GO:0051604	protein maturation	Zmpste24	IDA		Mouse	MGI:MGI:5796042|PMID:27462105
Biological Process	GO:0016485	protein processing	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:11923874
Biological Process	GO:0010506	regulation of autophagy	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:18443001
Biological Process	GO:1903522	regulation of blood circulation	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:18443001
Biological Process	GO:0030500	regulation of bone mineralization	Zmpste24	IGI	MGI:MGI:1099440	Mouse	PMID:23695662
Biological Process	GO:0008360	regulation of cell shape	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:16079796
Biological Process	GO:2000772	regulation of cellular senescence	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:21746928
Biological Process	GO:2000772	regulation of cellular senescence	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:16079796
Biological Process	GO:2000772	regulation of cellular senescence	Zmpste24	IGI	MGI:MGI:1888594	Mouse	PMID:23686339
Biological Process	GO:0050688	regulation of defense response to virus	ZMPSTE24	IDA		Human	PMID:28246125
Biological Process	GO:0050688	regulation of defense response to virus	Zmpste24	IMP	MGI:MGI:2158363	Mouse	PMID:28246125
Biological Process	GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:16079796
Biological Process	GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	Zmpste24	IGI	MGI:MGI:98834	Mouse	PMID:21522133
Biological Process	GO:0044030	regulation of DNA methylation	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:20961378
Biological Process	GO:0006355	regulation of DNA-templated transcription	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:20961378
Biological Process	GO:0048145	regulation of fibroblast proliferation	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:16079796
Biological Process	GO:0010906	regulation of glucose metabolic process	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:18443001
Biological Process	GO:0008016	regulation of heart contraction	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:27799555
Biological Process	GO:0032350	regulation of hormone metabolic process	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:18443001
Biological Process	GO:0019216	regulation of lipid metabolic process	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:18443001
Biological Process	GO:0007346	regulation of mitotic cell cycle	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:16079796
Biological Process	GO:1903463	regulation of mitotic cell cycle DNA replication	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:15980864
Biological Process	GO:0040014	regulation of multicellular organism growth	Zmpste24	IGI	MGI:MGI:1099440	Mouse	PMID:23695662
Biological Process	GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:15980864
Biological Process	GO:0070302	regulation of stress-activated protein kinase signaling cascade	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:16079796
Biological Process	GO:2000730	regulation of termination of RNA polymerase I transcription	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:20961378
Biological Process	GO:0032006	regulation of TOR signaling	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:18443001
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:27799555
Biological Process	GO:0072423	response to DNA damage checkpoint signaling	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:15980864
Biological Process	GO:0048538	thymus development	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:11923874
Biological Process	GO:0003229	ventricular cardiac muscle tissue development	Zmpste24	IMP	MGI:MGI:2180033	Mouse	PMID:27799555

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern