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Zmpste24 Gene Detail
Summary
  • Symbol
    Zmpste24
  • Name
    zinc metallopeptidase, STE24
  • Synonyms
    A530043O15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890508
    NCBI Gene: 230709
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:121059237-121098241 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      39005 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 56.80 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ZMPSTE24, zinc metallopeptidase STE24
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZMPSTE24, zinc metallopeptidase STE24
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FACE1, FACE-1, HGPS, PRO1, STE24, Ste24p
  • Links
    NCBI Gene ID: 10269
    neXtProt AC: NX_O75844
    UniProt: O75844

  • Chr Location
    1p34.2; chr1:40258050-40294184 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    4 with Zmpste24 mouse models; 1 with human ZMPSTE24 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
IDs
View 1 model
IDs
View 3 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    76 phenotypes from 2 alleles in 5 genetic backgrounds
    18 phenotypes from multigenic genotypes
    4 images
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutants are deficient in proteolytic processing of prelamin A and display many abnormalities including retarded growth, bone fragility, hair loss, cardiomyopathy, muscular dystrophy and lipodystrophy. Most die prematurely, but some survive and reproduce.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000008909 VEGA Gene Model | MGI Sequence Detail 39005 C57BL/6J ±  kb
    transcript OTTMUST00000020234 VEGA | MGI Sequence Detail 3429 Not Applicable  
    polypeptide OTTMUSP00000009273 VEGA | MGI Sequence Detail 475 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      242 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2443572
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 1
      Diseases 5
      Gene Ontology 5
      Phenotypes 39
    • Earliest
      J:70661 Leung GK, et al., Biochemical studies of Zmpste24-deficient mice. J Biol Chem. 2001 Aug 3;276(31):29051-8
    • Latest
      J:261917 Whitton H, et al., Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver. Aging Cell. 2018 Jun;17(3):e12742

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/03/2018
    MGI 6.12
    The Jackson Laboratory