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Zmpste24
Gene Detail
Symbol

Name
ID
Zmpste24
zinc metallopeptidase, STE24
MGI:1890508
Synonyms
A530043O15Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 4
56.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:121059237-121098241 bp, - strand
From VEGA annotation of GRCm38

  39005 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4277  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Zmpste24

Human
homologs
Human Homolog ZMPSTE24, zinc metallopeptidase STE24
NCBI Gene ID 10269
neXtProt AC  NX_O75844
Human Synonyms  FACE1, FACE-1, HGPS, PRO1, STE24, Ste24p
Human Chr (Location)  1p34; chr1:40258050-40294184 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human ZMPSTE24
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mutants are deficient in proteolytic processing of prelamin A and display many abnormalities including retarded growth, bone fragility, hair loss, cardiomyopathy, muscular dystrophy and lipodystrophy. Most die prematurely, but some survive and reproduce.
 
Human Diseases Modeled Using Mouse Zmpste24 (4)    Alleles Annotated to Human Diseases(2)    Phenotype Images(4)
Interactions
Zmpste24 interacts with 277 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process CAAX-box protein processing, nuclear envelope organization, ...
Component endoplasmic reticulum, extracellular vesicular exosome, ...
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 2
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000008909 (Evidence)
Ensembl Gene ModelENSMUSG00000043207 (Evidence)
Entrez Gene230709 (Evidence)
DFCITC1577999, TC1598551
DoTSDT.529811, DT.97375507
NIA Mouse Gene IndexU041007, U330686
EC3.4.24.84
Consensus CDS ProjectCCDS18600.1
International Mouse Knockout Project StatusZmpste24
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008909 VEGA Gene Model | MGI Sequence Detail 39005 C57BL/6J ±  kb
transcript OTTMUST00000020234 VEGA | MGI Sequence Detail 3429 Not Applicable 
polypeptide OTTMUSP00000009273 VEGA | MGI Sequence Detail 475 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(267 from dbSNP Build 137)    SNPs within 2kb including multiple locations(291)
Protein-related
information
ResourceIDDescription
InterPro IPR027057 CAAX prenyl protease 1
InterPro IPR001915 Peptidase M48
Protein Ontology PR:000017685 CAAX prenyl protease 1
References
(Earliest) J:70661 Leung GK, et al., Biochemical studies of Zmpste24-deficient mice. J Biol Chem. 2001 Aug 3;276(31):29051-8
(Latest) J:199185 Ibrahim MX, et al., Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria. Science. 2013 Jun 14;340(6138):1330-3
All references(51)
Disease annotation references (5)
Other
accession IDs
MGI:2443572

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory