Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TIMP1
  • Mouse genes Timp1
  • Rat genes Timp1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Timp1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	TIMP1	IDA		Human	PMID:3839290
Molecular Function	GO:0008191	metalloendopeptidase inhibitor activity	TIMP1	IDA		Human	PMID:12714508
Molecular Function	GO:0008191	metalloendopeptidase inhibitor activity	TIMP1	IDA		Human	PMID:3903517
Molecular Function	GO:0030414	peptidase inhibitor activity	TIMP1	IDA		Human	PMID:9573338
Molecular Function	GO:0002020	protease binding	Timp1	IPI	RGD:1307917	Rat	PMID:21846328|RGD:7207284
Molecular Function	GO:0005515	protein binding	TIMP1	IPI	UniProtKB:P08962	Human	PMID:16917503
Molecular Function	GO:0005515	protein binding	TIMP1	IPI	UniProtKB:P20908	Human	PMID:20979576
Molecular Function	GO:0005515	protein binding	TIMP1	IPI	UniProtKB:P14780	Human	PMID:2251898
Molecular Function	GO:0005515	protein binding	TIMP1	IPI	UniProtKB:P08962	Human	PMID:28030805
Molecular Function	GO:0005515	protein binding	TIMP1	IPI	UniProtKB:P27701	Human	PMID:28030805
Molecular Function	GO:0005515	protein binding	Timp1	IPI	UniProtKB:P98158	Rat	PMID:28659595|RGD:13210547
Molecular Function	GO:0008270	zinc ion binding	TIMP1	IDA		Human	PMID:22427646
Cellular Component	GO:0005604	basement membrane	Timp1	IDA		Mouse	PMID:12950084
Cellular Component	GO:0005604	basement membrane	Timp1	IDA		Rat	PMID:9579471|RGD:2290365
Cellular Component	GO:0070062	extracellular exosome	TIMP1	HDA		Human	PMID:23533145
Cellular Component	GO:0031012	extracellular matrix	Timp1	IDA		Mouse	PMID:12950084
Cellular Component	GO:0005615	extracellular space	TIMP1	IDA		Human	PMID:3903517
Cellular Component	GO:0005615	extracellular space	Timp1	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Biological Process	GO:0007568	aging	Timp1	IEP		Rat	PMID:18278151|RGD:2290357
Biological Process	GO:0051216	cartilage development	Timp1	IEP		Rat	PMID:16208432|RGD:8694091
Biological Process	GO:0001775	cell activation	Timp1	IMP		Rat	PMID:15389776|RGD:1580120
Biological Process	GO:0071492	cellular response to UV-A	TIMP1	IDA		Human	PMID:31380578
Biological Process	GO:0002248	connective tissue replacement involved in inflammatory response wound healing	Timp1	IDA		Mouse	PMID:23100531
Biological Process	GO:0043066	negative regulation of apoptotic process	Timp1	IMP		Rat	PMID:12081564|RGD:1580121
Biological Process	GO:0043086	negative regulation of catalytic activity	TIMP1	IDA		Human	PMID:3903517
Biological Process	GO:0010951	negative regulation of endopeptidase activity	TIMP1	IDA		Human	PMID:3903517
Biological Process	GO:0051045	negative regulation of membrane protein ectodomain proteolysis	TIMP1	IDA		Human	PMID:12714508
Biological Process	GO:1905049	negative regulation of metallopeptidase activity	TIMP1	IDA		Human	PMID:9573338
Biological Process	GO:1901164	negative regulation of trophoblast cell migration	TIMP1	IMP		Human	PMID:21356369
Biological Process	GO:0008284	positive regulation of cell population proliferation	TIMP1	IDA		Human	PMID:3839290
Biological Process	GO:2001044	regulation of integrin-mediated signaling pathway	TIMP1	IMP		Human	PMID:16917503
Biological Process	GO:0034097	response to cytokine	Timp1	IEP		Rat	PMID:10435007|RGD:2290469
Biological Process	GO:0010033	response to organic substance	Timp1	IEP		Rat	PMID:17555880|RGD:2290355
Biological Process	GO:0043434	response to peptide hormone	Timp1	IEP		Rat	PMID:1327205|RGD:2290366
Biological Process	GO:0042060	wound healing	Timp1	IEP		Rat	PMID:9579471|RGD:2290365

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern