About   Help   FAQ
Timp1 Gene Detail
Summary
  • Symbol
    Timp1
  • Name
    tissue inhibitor of metalloproteinase 1
  • Synonyms
    Clgi, MGC:7143, TIMP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98752
    NCBI Gene: 21857
  • Gene Overview
    MyGene.info: TIMP1
Location & Maps
more
  • Sequence Map
    ChrX:20870166-20874735 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4570 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TIMP1, TIMP metallopeptidase inhibitor 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    TIMP1, TIMP metallopeptidase inhibitor 1
    Orthology source: HomoloGene
  • Synonyms
    CLGI, EPA, EPO, HCI, TIMP, TIMP-1
  • Links
    NCBI Gene ID: 7076
    neXtProt AC: NX_P01033

  • Chr Location
    Xp11.3-p11.23; chrX:47582291-47586791 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 2 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Gene trapped
    15
  • Targeted
    4
  • Transgenic
    1
Nullizygous mice show altered endometrial gland number and estrous cycles, increased uterus and testis weight, reduced female fertility, aortic aneurysms, reduced bone marrow cellularity and susceptibility to bacterial infection, and altered response to myocardium infarction and induced lung injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017184 VEGA Gene Model | MGI Sequence Detail 4570 C57BL/6J ±  kb
transcript OTTMUST00000041617 VEGA | MGI Sequence Detail 883 Not Applicable  
polypeptide OTTMUSP00000018692 VEGA | MGI Sequence Detail 205 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    21 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000016352 metalloproteinase inhibitor 1
  • InterPro Domains
    IPR015611 Metalloproteinase inhibitor 1
    IPR001134 Netrin domain
    IPR001820 Protease inhibitor I35 (TIMP)
    IPR027465 Proteinase inhibitor I35b (TIMP), C-terminal
    IPR030490 Tissue inhibitor of metalloproteinase, conserved site
    IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Molecular
Reagents
less
  • All nucleic 65
    Genomic 9
    cDNA 50
    Primer pair 6

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-15110, MGD-MRK-2015
References
more
  • Summaries
    All 172
    Developmental Gene Expression 46
    Gene Ontology 5
    Phenotypes 59
  • Earliest
    J:6817 Skup D, et al., Molecular cloning of partial cDNA copies of two distinct mouse IFN-beta mRNAs. Nucleic Acids Res. 1982 May 25;10(10):3069-84
  • Latest
    J:224431 Besschetnova TY, et al., Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis. Matrix Biol. 2015 Mar;42:56-73

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/26/2016
MGI 6.03
The Jackson Laboratory