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Timp1 Gene Detail
Summary
  • Symbol
    Timp1
  • Name
    tissue inhibitor of metalloproteinase 1
  • Synonyms
    Clgi, MGC:7143, TIMP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98752
    NCBI Gene: 21857
  • Gene Overview
    MyGene.info: TIMP1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:20870166-20874735 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 16.38 cM
  • Mapping Data
    19 experiments
Strain
Comparison
more
  • SNPs within 2kb
    21 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98752
protein coding gene ChrX:20870166-20874737 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035599
protein coding gene ChrX:15765602-15770171 (+)
A/J MGP_AJ_G0035576
protein coding gene ChrX:15851870-15856439 (+)
AKR/J MGP_AKRJ_G0035509
protein coding gene ChrX:16404668-16409237 (+)
BALB/cJ MGP_BALBcJ_G0035569
protein coding gene ChrX:15619857-15624426 (+)
C3H/HeJ MGP_C3HHeJ_G0035287
protein coding gene ChrX:15988929-15993534 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036105
protein coding gene ChrX:16184043-16188612 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032969
protein coding gene ChrX:14109238-14113807 (+)
CAST/EiJ MGP_CASTEiJ_G0034578
protein coding gene ChrX:15281637-15286203 (+)
CBA/J MGP_CBAJ_G0035256
protein coding gene ChrX:16924752-16929321 (+)
DBA/2J MGP_DBA2J_G0035408
protein coding gene ChrX:15650947-15655516 (+)
FVB/NJ MGP_FVBNJ_G0035354
protein coding gene ChrX:15561262-15565891 (+)
LP/J MGP_LPJ_G0035490
protein coding gene ChrX:16021321-16025890 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035398
protein coding gene ChrX:17182679-17187248 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036112
protein coding gene ChrX:15688001-15692570 (+)
PWK/PhJ MGP_PWKPhJ_G0034279
protein coding gene ChrX:14851683-14856249 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034119
protein coding gene ChrX:15684476-15689392 (+)
WSB/EiJ MGP_WSBEiJ_G0034713
protein coding gene ChrX:15554597-15559166 (+)



Homology
more
  • Human Ortholog
    TIMP1, TIMP metallopeptidase inhibitor 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    TIMP1, TIMP metallopeptidase inhibitor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CLGI, EPA, EPO, HCI, TIMP, TIMP-1
  • Links
    NCBI Gene ID: 7076
    neXtProt AC: NX_P01033
    UniProt: P01033

  • Chr Location
    Xp11.3; chrX:47582291-47586791 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 2 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mice show altered endometrial gland number and estrous cycles, increased uterus and testis weight, reduced female fertility, aortic aneurysms, reduced bone marrow cellularity and susceptibility to bacterial infection, and altered response to myocardium infarction and induced lung injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001131 Ensembl Gene Model | MGI Sequence Detail 4570 C57BL/6J ±  kb
    transcript ENSMUST00000115342 Ensembl | MGI Sequence Detail 883 Not Applicable  
    polypeptide ENSMUSP00000110999 Ensembl | MGI Sequence Detail 205 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 69
      Genomic 9
      cDNA 53
      Primer pair 6
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15110, MGD-MRK-2015
    References
    more
    • Summaries
      All 207
      Developmental Gene Expression 50
      Gene Ontology 7
      Phenotypes 66
    • Earliest
      J:6817 Skup D, et al., Molecular cloning of partial cDNA copies of two distinct mouse IFN-beta mRNAs. Nucleic Acids Res. 1982 May 25;10(10):3069-84
    • Latest
      J:273336 Flood HM, et al., The Forkhead box F1 transcription factor inhibits collagen deposition and accumulation of myofibroblasts during liver fibrosis. Biol Open. 2019 Feb 11;8(2)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    07/09/2019
    MGI 6.14
    The Jackson Laboratory