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Timp1
Gene Detail
Symbol

Name
ID
Timp1
tissue inhibitor of metalloproteinase 1
MGI:98752
Synonyms
Clgi, MGC:7143, TIMP-1
Feature Type
protein coding gene
Genetic Map
Chromosome X
16.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
ChrX:20870166-20874735 bp, + strand
From VEGA annotation of GRCm38

  4570 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36321  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: metalloproteinase inhibitor
Gene Tree: Timp1

Human
homologs
Human Homolog TIMP1, TIMP metallopeptidase inhibitor 1
NCBI Gene ID 7076
neXtProt AC  NX_P01033
Human Synonyms  CLGI, EPA, EPO, HCI, TIMP
Human Chr (Location)  Xp11.3-p11.23; chrX:47582291-47586791 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(15) Targeted(3)
 
Nullizygous mice show altered endometrial gland number and estrous cycles, increased uterus and testis weight, reduced female fertility, aortic aneurysms, reduced bone marrow cellularity and susceptibility to bacterial infection, and altered response to myocardium infarction and induced lung injury.
 
Interactions
Timp1 interacts with 29 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cell activation, negative regulation of apoptotic process, ...
Component basement membrane, extracellular matrix, ...
Function cytokine activity, enzyme inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (42 records)
Data Summary: Results (197)    Tissues (101)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 119
Northern blot 18
Western blot 28
RT-PCR 28
cDNA source data(49)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(64) Genomic(9) cDNA(50) Primer pair(5)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017184 (Evidence)
Ensembl Gene ModelENSMUSG00000001131 (Evidence)
Entrez Gene21857 (Evidence)
UniGene8245
DFCITC1578071, TC1745019, TC1746283
DoTSDT.101387924, DT.111029799, DT.491485, DT.94363271
NIA Mouse Gene IndexU019754
Consensus CDS ProjectCCDS30046.1
International Mouse Knockout Project StatusTimp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017184 VEGA Gene Model | MGI Sequence Detail 4570 C57BL/6J ±  kb
transcript OTTMUST00000041617 VEGA | MGI Sequence Detail 883 Not Applicable 
polypeptide OTTMUSP00000018692 VEGA | MGI Sequence Detail 205 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(8) : SNPs within 2kb(21 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001134 Netrin domain
InterPro IPR001820 Proteinase inhibitor I35, tissue inhibitor of metalloproteinase
InterPro IPR027465 Proteinase inhibitor I35, tissue inhibitor of metalloproteinase, C-terminal domain
InterPro IPR015611 Tissue inhibitor of metalloprotease 1
InterPro IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology PR:000016352 metalloproteinase inhibitor 1
References
(Earliest) J:6817 Skup D, et al., Molecular cloning of partial cDNA copies of two distinct mouse IFN-beta mRNAs. Nucleic Acids Res. 1982 May 25;10(10):3069-84
(Latest) J:211441 Basu R, et al., TIMP3 is the primary TIMP to regulate agonist-induced vascular remodelling and hypertension. Cardiovasc Res. 2013 Jun 1;98(3):360-71
All references(165)
Other
accession IDs
MGD-MRK-15110, MGD-MRK-2015

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory