Timp1 MGI Mouse Gene Detail - MGI:98752 - tissue inhibitor of metalloproteinase 1

Symbol

Timp1
Name

tissue inhibitor of metalloproteinase 1
Synonyms

Clgi, MGC:7143, TIMP-1

Feature Type

protein coding gene
IDs

MGI:98752
NCBI Gene: 21857
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

ChrX:20736524-20740972 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 16.38 cM
Mapping Data

19 experiments

SNPs within 2kb

131 from dbSNP Build 142
Strain Annotations

19
RFLP

8

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98752	protein coding gene	ChrX:20736405-20740974 (+)
129S1/SvImJ	ENSMUSG00200014928	protein coding gene	ChrX:15500370-15504939 (+)
A/J	ENSMUSG00195007156	protein coding gene	ChrX:15501441-15506011 (+)
AKR/J	ENSMUSG00220017610	protein coding gene	ChrX:14996231-15000801 (+)
BALB/cJ	ENSMUSG00180021925	protein coding gene	ChrX:15435102-15439671 (+)
C3H/HeJ	ENSMUSG00175027987	protein coding gene	ChrX:15475708-15480278 (+)
C57BL/6NJ	ENSMUSG00215015044	protein coding gene	ChrX:16079717-16084287 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032969	protein coding gene	ChrX:14109238-14113807 (+)
CAST/EiJ	ENSTCUG00005026304	protein coding gene	ChrX:15409701-15414268 (+)
CBA/J	ENSMUSG00210020312	protein coding gene	ChrX:15532281-15536851 (+)
DBA/2J	ENSMUSG00185030796	protein coding gene	ChrX:22132884-22137454 (+)
FVB/NJ	ENSMUSG00205017686	protein coding gene	ChrX:15076493-15081063 (+)
JF1/MsJ	ENSUMUG00000021416	protein coding gene	ChrX:35958938-35963504 (+)
LP/J	ENSMUSG00230005577	protein coding gene	ChrX:26702136-26706705 (+)
NOD/ShiLtJ	ENSMUSG00190027770	protein coding gene	ChrX:15478766-15483336 (+)
NZO/HlLtJ	ENSMUSG00225041151	protein coding gene	ChrX:31942060-31946629 (+)
PWK/PhJ	ENSLUMG00010015635	protein coding gene	ChrX:15364825-15369391 (+)
SPRET/EiJ	ENSMSPG00010010514	protein coding gene	ChrX:16632082-16636646 (+)
WSB/EiJ	ENSIUOG00005029583	protein coding gene	ChrX:12081331-12085900 (+)

Human Ortholog

TIMP1, TIMP metallopeptidase inhibitor 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TIMP1, TIMP metallopeptidase inhibitor 1
Synonyms

CLGI, EPA, EPO, HCI, TIMP, TIMP-1
Links

HGNC:11820

NCBI Gene ID: 7076

UniProt: P01033
Chr Location

Xp11.3; chrX:47582408-47586789 (+) GRCh38

MGI Vertebrate Homology

Timp1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TIMP1
Gene Tree

Timp1

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Phenotype Summary

34 phenotypes from 2 alleles in 4 genetic backgrounds
3 phenotypes from multigenic genotypes
87 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Endonuclease-mediated

7
Gene trapped

15
Targeted

5
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Nullizygous mice show altered endometrial gland number and estrous cycles, increased uterus and testis weight, reduced female fertility, aortic aneurysms, reduced bone marrow cellularity and susceptibility to bacterial infection, and altered response to myocardium infarction and induced lung injury.

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All GO Annotations

55
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1025
Tissues

199
cDNA Data

55
Literature Summary

67

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase timp1

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All Sequences

53
RefSeq

12
UniProt

2
CCDS

CCDS30046.1

Ensembl

ENSMUSG00000001131 (Evidence)
NCBI Gene

21857

			Length	Strain/Species	Flank
genomic	21857	NCBI Gene Model \| MGI Sequence Detail	4449	C57BL/6J	± kb
transcript	NM_001044384	RefSeq \| MGI Sequence Detail	767	C57BL/6
polypeptide	P12032	UniProt \| EBI \| MGI Sequence Detail	205	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016352 metalloproteinase inhibitor 1

(term hierarchy)
InterPro Domains

IPR001134 Netrin domain

IPR001820 Protease inhibitor I35 (TIMP)

IPR027465 Proteinase inhibitor I35b (TIMP), C-terminal

IPR030490 Tissue inhibitor of metalloproteinase, conserved site

IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
GlyGen

P12032 2 sites, 1 N-linked glycan (1 site)

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All nucleic 83

Genomic 9

cDNA 56

Primer pair 15

Other 3

Antibodies 3

Microarray probesets 4

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MGD-MRK-15110, MGD-MRK-2015

Summaries

All 291

Developmental Gene Expression 67

Gene Ontology 12

Phenotypes 87
Earliest

J:6817 Skup D, et al., Molecular cloning of partial cDNA copies of two distinct mouse IFN-beta mRNAs. Nucleic Acids Res. 1982 May 25;10(10):3069-84
Latest

J:384797 Bobo-Jimenez V, et al., Perinatal liver sympathetic innervation governs body size. Commun Biol. 2026 Mar 14;9(1)

TSS for Timp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160688	ChrX:20736454-20736465 (+)	-64 bp
Tssr160689	ChrX:20736475-20736512 (+)	-30 bp
Tssr160690	ChrX:20736515-20736537 (+)	2 bp
Tssr160691	ChrX:20737348-20737367 (+)	834 bp
Tssr160692	ChrX:20739016-20739059 (+)	2,514 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24