Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Tgfb3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes TGFB3
- Mouse genes Tgfb3
- Rat genes Tgfb3
- Zfish genes tgfb3
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tgfb3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	TGFB3	IDA		Human	PMID:18243111
Molecular Function	GO:0042802	identical protein binding	TGFB3	IPI	UniProtKB:P10600	Human	PMID:19073914
Molecular Function	GO:0042802	identical protein binding	TGFB3	IPI	UniProtKB:P10600	Human	PMID:21423151
Molecular Function	GO:0005515	protein binding	TGFB3	IPI	UniProtKB:Q14766	Human	PMID:10930463
Molecular Function	GO:0005515	protein binding	TGFB3	IPI	UniProtKB:Q9NS15	Human	PMID:10930463
Molecular Function	GO:0005515	protein binding	TGFB3	IPI	UniProtKB:P37173-1	Human	PMID:11157754
Molecular Function	GO:0005515	protein binding	TGFB3	IPI	UniProtKB:P37173-2	Human	PMID:11157754
Molecular Function	GO:0005515	protein binding	TGFB3	IPI	UniProtKB:P37173	Human	PMID:11850637
Molecular Function	GO:0005515	protein binding	TGFB3	IPI	UniProtKB:P17813	Human	PMID:1326540
Molecular Function	GO:0005515	protein binding	TGFB3	IPI	UniProtKB:Q99MQ4	Human	PMID:17827158
Molecular Function	GO:0005515	protein binding	TGFB3	IPI	UniProtKB:P36897	Human	PMID:18243111
Molecular Function	GO:0005515	protein binding	TGFB3	IPI	UniProtKB:P37173	Human	PMID:18243111
Molecular Function	GO:0005515	protein binding	TGFB3	IPI	UniProtKB:P37173	Human	PMID:21423151
Molecular Function	GO:0005515	protein binding	TGFB3	IPI	UniProtKB:P37173	Human	PMID:7852346
Molecular Function	GO:0005515	protein binding	TGFB3	IPI	UniProtKB:P17813	Human	PMID:9872992
Molecular Function	GO:0005515	protein binding	Tgfb3	IPI	UniProtKB:G3XA59	Mouse	MGI:MGI:5920420\|PMID:28912269
Molecular Function	GO:0044877	protein-containing complex binding	Tgfb3	IDA		Rat	PMID:18406405\|RGD:2302086
Molecular Function	GO:0050431	transforming growth factor beta binding	TGFB3	IDA		Human	PMID:18243111
Molecular Function	GO:0034713	type I transforming growth factor beta receptor binding	TGFB3	IDA		Human	PMID:18243111
Molecular Function	GO:0005114	type II transforming growth factor beta receptor binding	TGFB3	IDA		Human	PMID:11157754
Molecular Function	GO:0005114	type II transforming growth factor beta receptor binding	TGFB3	IPI	UniProtKB:P37173	Human	PMID:1333888
Molecular Function	GO:0005114	type II transforming growth factor beta receptor binding	TGFB3	IDA		Human	PMID:18243111
Molecular Function	GO:0005114	type II transforming growth factor beta receptor binding	TGFB3	IMP	UniProtKB:Q90999	Human	PMID:8167376
Molecular Function	GO:0034714	type III transforming growth factor beta receptor binding	TGFB3	IMP	UniProtKB:Q90998	Human	PMID:8167376
Cellular Component	GO:0009986	cell surface	Tgfb3	IDA		Rat	PMID:16479080\|RGD:2302094
Cellular Component	GO:0062023	collagen-containing extracellular matrix	TGFB3	IDA		Human	PMID:18049952
Cellular Component	GO:0005737	cytoplasm	Tgfb3	IDA		Rat	PMID:9281452\|RGD:1625705
Cellular Component	GO:0031012	extracellular matrix	Tgfb3	IDA		Mouse	PMID:10521784
Cellular Component	GO:0005615	extracellular space	Tgfb3	IDA		Rat	PMID:16891311\|RGD:1625706
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	TGFB3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043025	neuronal cell body	Tgfb3	IDA		Rat	PMID:15214860\|RGD:1601584
Cellular Component	GO:0005634	nucleus	Tgfb3	IDA		Rat	PMID:9281452\|RGD:1625705
Cellular Component	GO:0030141	secretory granule	Tgfb3	IDA		Rat	PMID:15214860\|RGD:1601584
Cellular Component	GO:0030315	T-tubule	Tgfb3	IDA		Rat	PMID:9281452\|RGD:1625705
Biological Process	GO:0007568	aging	Tgfb3	IEP		Rat	PMID:12051734\|RGD:2302033
Biological Process	GO:0009887	animal organ morphogenesis	Tgfb3	IMP	MGI:MGI:1857259	Mouse	PMID:14697364
Biological Process	GO:0008283	cell population proliferation	Tgfb3	IDA		Mouse	PMID:12815624
Biological Process	GO:0045216	cell-cell junction organization	TGFB3	IDA		Human	PMID:18505915
Biological Process	GO:0071363	cellular response to growth factor stimulus	Tgfb3	IDA		Mouse	PMID:7848824
Biological Process	GO:0070483	detection of hypoxia	TGFB3	IDA		Human	PMID:18156205
Biological Process	GO:0048565	digestive tract development	Tgfb3	IEP		Rat	PMID:12815632\|RGD:2302031
Biological Process	GO:0009790	embryo development	Tgfb3	IMP	MGI:MGI:2158731	Mouse	PMID:14729481
Biological Process	GO:0048702	embryonic neurocranium morphogenesis	Tgfb3	IDA		Rat	PMID:11002343\|RGD:1579866
Biological Process	GO:0050673	epithelial cell proliferation	Tgfb3	IDA		Mouse	PMID:12815624
Biological Process	GO:0060325	face morphogenesis	TGFB3	IMP		Human	PMID:12651933
Biological Process	GO:0060325	face morphogenesis	Tgfb3	IEP		Mouse	MGI:MGI:3796269\|PMID:18498113
Biological Process	GO:0007565	female pregnancy	Tgfb3	IEP		Rat	PMID:15927076\|RGD:2302099
Biological Process	GO:0046847	filopodium assembly	Tgfb3	IMP	MGI:MGI:2158731	Mouse	PMID:16806156
Biological Process	GO:0060364	frontal suture morphogenesis	Tgfb3	IEP		Rat	PMID:12416537\|RGD:2302805
Biological Process	GO:0010467	gene expression	Tgfb3	IMP		Mouse	PMID:16245336
Biological Process	GO:0060218	hematopoietic stem cell differentiation	tgfb3	IGI	ZFIN:ZDB-GENE-030618-1,ZFIN:ZDB-GENE-091028-1	Zfish	PMID:27499523
Biological Process	GO:0001701	in utero embryonic development	Tgfb3	IMP	MGI:MGI:2158731	Mouse	PMID:14729481
Biological Process	GO:0048839	inner ear development	Tgfb3	IEP		Rat	PMID:16479080\|RGD:2302094
Biological Process	GO:0048286	lung alveolus development	Tgfb3	IMP		Mouse	MGI:MGI:77427\|PMID:7493022
Biological Process	GO:0030879	mammary gland development	Tgfb3	IDA		Mouse	PMID:1821856
Biological Process	GO:0008285	negative regulation of cell population proliferation	TGFB3	IMP		Human	PMID:11158066
Biological Process	GO:0008285	negative regulation of cell population proliferation	Tgfb3	IDA		Rat	PMID:11002343\|RGD:1579866
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Tgfb3	IDA		Mouse	PMID:12815624
Biological Process	GO:0010936	negative regulation of macrophage cytokine production	TGFB3	IDA		Human	PMID:20875417
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Tgfb3	IMP	MGI:MGI:1857259	Mouse	PMID:17159989
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Tgfb3	IDA		Rat	PMID:12071374\|RGD:730235
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	TGFB3	IDA		Human	PMID:26315405
Biological Process	GO:0051402	neuron apoptotic process	Tgfb3	IMP	MGI:MGI:1857259	Mouse	PMID:17159989
Biological Process	GO:0043065	positive regulation of apoptotic process	Tgfb3	IMP	MGI:MGI:2158731	Mouse	PMID:16806156
Biological Process	GO:0043065	positive regulation of apoptotic process	Tgfb3	IDA		Rat	PMID:11002343\|RGD:1579866
Biological Process	GO:0043065	positive regulation of apoptotic process	Tgfb3	IMP		Rat	PMID:16532270\|RGD:2302092
Biological Process	GO:0008284	positive regulation of cell population proliferation	TGFB3	IMP		Human	PMID:11158066
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	TGFB3	IMP		Human	PMID:11158066
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	TGFB3	IDA		Human	PMID:18156205
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Tgfb3	IMP		Mouse	MGI:MGI:2683382\|PMID:14691138
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	TGFB3	IDA		Human	PMID:18505915
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	TGFB3	IDA		Human	PMID:18718461
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	Tgfb3	IMP		Mouse	MGI:MGI:2683382\|PMID:14691138
Biological Process	GO:0051491	positive regulation of filopodium assembly	Tgfb3	IMP	MGI:MGI:2158731	Mouse	PMID:16806156
Biological Process	GO:0010628	positive regulation of gene expression	Tgfb3	IDA		Mouse	MGI:MGI:5688835\|PMID:21984612
Biological Process	GO:0043410	positive regulation of MAPK cascade	Tgfb3	IDA		Rat	PMID:14605008\|RGD:1579859
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	Tgfb3	IMP		Mouse	MGI:MGI:2683382\|PMID:14691138
Biological Process	GO:0050714	positive regulation of protein secretion	TGFB3	IDA		Human	PMID:18505915
Biological Process	GO:0060391	positive regulation of SMAD protein signal transduction	Tgfb3	IMP		Mouse	MGI:MGI:2683382\|PMID:14691138
Biological Process	GO:0051496	positive regulation of stress fiber assembly	TGFB3	IDA		Human	PMID:18718461
Biological Process	GO:1905075	positive regulation of tight junction disassembly	TGFB3	IDA		Human	PMID:18718461
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tgfb3	IGI	MGI:MGI:108051	Mouse	PMID:17159989
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tgfb3	IGI	MGI:MGI:1201674	Mouse	PMID:17159989
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tgfb3	IGI	MGI:MGI:1314872	Mouse	PMID:17159989
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tgfb3	IGI	MGI:MGI:894293	Mouse	PMID:17159989
Biological Process	GO:0061035	regulation of cartilage development	tgfb3	IMP	ZFIN:ZDB-MRPHLNO-100630-2	Zfish	PMID:20406684
Biological Process	GO:0061035	regulation of cartilage development	tgfb3	IMP	ZFIN:ZDB-MRPHLNO-110929-8	Zfish	PMID:20406684
Biological Process	GO:0061035	regulation of cartilage development	tgfb3	IMP	ZFIN:ZDB-MRPHLNO-100630-2,ZFIN:ZDB-MRPHLNO-110929-7	Zfish	PMID:20406684
Biological Process	GO:0061035	regulation of cartilage development	tgfb3	IMP	ZFIN:ZDB-MRPHLNO-110929-7	Zfish	PMID:20406684
Biological Process	GO:0030278	regulation of ossification	tgfb3	IMP	ZFIN:ZDB-MRPHLNO-100630-2,ZFIN:ZDB-MRPHLNO-110929-7	Zfish	PMID:20406684
Biological Process	GO:0043627	response to estrogen	Tgfb3	IDA		Rat	PMID:14605008\|RGD:1579859
Biological Process	GO:0001666	response to hypoxia	TGFB3	IDA		Human	PMID:18156205
Biological Process	GO:0001666	response to hypoxia	Tgfb3	IEP		Rat	PMID:14697406\|RGD:1625703
Biological Process	GO:0034616	response to laminar fluid shear stress	Tgfb3	IEP		Rat	PMID:16217485\|RGD:2302098
Biological Process	GO:0032570	response to progesterone	TGFB3	IDA		Human	PMID:18039789
Biological Process	GO:0060021	roof of mouth development	Tgfb3	IMP		Mouse	PMID:16245336
Biological Process	GO:0007435	salivary gland morphogenesis	TGFB3	IEP		Human	PMID:18080134
Biological Process	GO:0062009	secondary palate development	Tgfb3	IMP		Mouse	MGI:MGI:5920420\|PMID:28912269
Biological Process	GO:0062009	secondary palate development	Tgfb3	IMP		Mouse	MGI:MGI:2683382\|PMID:14691138
Biological Process	GO:0062009	secondary palate development	Tgfb3	IMP		Mouse	MGI:MGI:77426\|PMID:7493021
Biological Process	GO:0062009	secondary palate development	Tgfb3	IMP		Mouse	MGI:MGI:77427\|PMID:7493022
Biological Process	GO:0062009	secondary palate development	Tgfb3	IMP		Mouse	MGI:MGI:1341549\|PMID:10433915
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	TGFB3	IDA		Human	PMID:11157754
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	TGFB3	IDA		Human	PMID:18718461
Biological Process	GO:0042060	wound healing	Tgfb3	IEP		Rat	PMID:18205704\|RGD:2292158

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.