About   Help   FAQ
Tgfb3
Gene Detail
Symbol

Name
ID
Tgfb3
transforming growth factor, beta 3
MGI:98727
Synonyms
Tgfb-3
Feature Type
protein coding gene
Genetic Map
Chromosome 12
40.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:86056744-86079041 bp, - strand
From Ensembl annotation of GRCm38

  22298 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2433  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: TGFB3
Protein SuperFamily: transforming growth factor-beta
Gene Tree: Tgfb3

Human
homologs
TGFB3, transforming growth factor, beta 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7043
neXtProt AC: NX_P10600

Human Synonyms: ARVD, ARVD1, RNHF, TGF-beta3

Human Chr (Location): 14q24; chr14:75958097-75982991 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human TGFB3

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit cleft palate, lung hypoplasia, hemothorax, impaired suckling, respiratory distress, and neonatal lethality.
 
Interactions
Tgfb3 interacts with 163 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (65 annotations)
Process activation of MAPK activity, cell-cell junction organization, ...
Component cell surface, cytoplasm, ...
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (116 records)
Data Summary: Results (248)    Tissues (172)    Images (74)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 71
RNA in situ 124
Northern blot 37
RT-PCR 16
cDNA source data(104)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA TGFB3 ZFIN tgfb3    NEW 
Molecular
reagents
All nucleic(120) cDNA(109) Primer pair(7) Other(4)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000021253 (Evidence)
Entrez Gene 21809 (Evidence)
UniGene 3992
DFCI TC1575978
DoTS DT.101710465, DT.492007
NIA Mouse Gene Index U034193
Consensus CDS Project CCDS49116.1
International Mouse Phenotyping Consortium Status Tgfb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021253 Ensembl Gene Model | MGI Sequence Detail 22298 C57BL/6J ±  kb
transcript ENSMUST00000003687 Ensembl | MGI Sequence Detail 3384 Not Applicable 
polypeptide ENSMUSP00000003687 Ensembl | MGI Sequence Detail 412 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(6)
Polymorphisms
SNPs within 2kb(131 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016319 Transforming growth factor-beta
InterPro IPR015618 Transforming growth factor beta 3
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000184 TGF-beta 3
References
(Earliest) J:9636 Barton DE, et al., Chromosomal mapping of genes for transforming growth factors beta 2 and beta 3 in man and mouse: dispersion of TGF-beta gene family. Oncogene Res. 1988;3(4):323-31
(Latest) J:218835 Lane J, et al., Tak1, Smad4 and Trim33 redundantly mediate TGF-beta3 signaling during palate development. Dev Biol. 2015 Feb 15;398(2):231-41
All references(205)
Other
accession IDs
MGD-MRK-15066, MGD-MRK-15069

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/20/2015
MGI 5.22
The Jackson Laboratory