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Tgfb3
Gene Detail
 Symbol
Name
ID
Tgfb3
transforming growth factor, beta 3
MGI:98727
Synonyms Tgfb-3
Feature Type protein coding gene
Genetic Map
Chromosome 12
40.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:86056744-86079041 bp, - strand
From Ensembl annotation of GRCm38

  22298 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2433  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transforming growth factor-beta
Gene Tree: Tgfb3

Human
homologs
Human Homolog TGFB3, transforming growth factor, beta 3
NCBI Gene ID 7043
neXtProt AC  NX_P10600
Human Synonyms  ARVD, ARVD1, RNHF, TGF-beta3
Human Chr (Location)  14q24; chr14:75958097-75982991 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human TGFB3
Alleles
and
phenotypes
All alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit cleft palate, lung hypoplasia, hemothorax, impaired suckling, respiratory distress, and neonatal lethality.
 
Gene Ontology
(GO)
classifications
All GO classifications: (57 annotations)
Process activation of MAPK activity, cell-cell junction organization, ...
Component cell surface, cytoplasm, ...
Function growth factor activity, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (108 records)
Data Summary: Results (247)    Tissues (171)    Images (73)
Theiler Stages: 1, 2, 3, 4, 9, 12, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 72
RNA in situ 124
Northern blot 37
RT-PCR 14
cDNA source data(104)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(119) cDNA(109) Primer pair(6) Other(4)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021253 (Evidence)
Entrez Gene21809 (Evidence)
UniGene3992
DFCITC1575978
DoTSDT.101710465, DT.492007
NIA Mouse Gene IndexU034193
Consensus CDS ProjectCCDS49116.1
International Mouse Knockout Project StatusTgfb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021253 Ensembl Gene Model | MGI Sequence Detail 22298 C57BL/6J ±  kb
transcript ENSMUST00000003687 Ensembl | MGI Sequence Detail 3384 Not Applicable 
polypeptide ENSMUSP00000003687 Ensembl | MGI Sequence Detail 412 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(6)
Polymorphisms SNPs within 2kb(131 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016319 Transforming growth factor-beta
InterPro IPR015618 Transforming growth factor beta 3
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000184 TGF-beta 3
References (Earliest) J:9636 Barton DE, et al., Chromosomal mapping of genes for transforming growth factors beta 2 and beta 3 in man and mouse: dispersion of TGF-beta gene family. Oncogene Res. 1988;3(4):323-31
(Latest) J:208341 Seth A, et al., Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
All references(196)
Other
accession IDs
MGD-MRK-15066, MGD-MRK-15069

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory