Tgfb3
Gene Detail

Symbol Name ID

Tgfb3 transforming growth factor, beta 3 MGI:98727

Synonyms

Tgfb-3

Feature Type

protein coding gene

Genetic Map

Chromosome 12

40.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr12:86056744-86079041 bp, - strand From Ensembl annotation of GRCm38   22298 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2433  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transforming growth factor-beta
Gene Tree: Tgfb3

Human homologs

Human Homolog		TGFB3, transforming growth factor, beta 3
NCBI Gene ID		7043
neXtProt AC		NX_P10600
Human Synonyms		ARVD, TGF-beta3
Human Chr (Location)		14q24; chr14:76424442-76448092 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TGFB3

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Homozygotes for targeted null mutations exhibit cleft palate, lung hypoplasia, hemothorax, impaired suckling, respiratory distress, and neonatal lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (57 annotations)

Process	activation of MAPK activity, cell-cell junction organization, ...
Component	cell surface, cytoplasm, ...
Function	growth factor activity, identical protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (103 records)
Data Summary: Results (188)    Tissues (146)    Images (49)
Theiler Stages: 1, 2, 3, 4, 9, 12, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	66
RNA in situ	71
Northern blot	37
RT-PCR	14

cDNA source data(100)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(113) cDNA(104) Primer pair(6) Other(3)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000021253 (Evidence)
Entrez Gene	21809 (Evidence)
UniGene	3992
DFCI	TC1575978
DoTS	DT.101710465, DT.492007
NIA Mouse Gene Index	U034193
Consensus CDS Project	CCDS49116.1
International Mouse Knockout Project Status	Tgfb3

Sequences

Length	Strain/Species
genomic	ENSMUSG00000021253	Ensembl Gene Model | MGI Sequence Detail	22298	C57BL/6J
transcript	ENSMUST00000003687	Ensembl | MGI Sequence Detail	3384	Not Applicable
polypeptide	ENSMUSP00000003687	Ensembl | MGI Sequence Detail	412	Not Applicable

All sequences(30) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(120 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016319	Transforming growth factor-beta
InterPro	IPR015618	Transforming growth factor beta 3
InterPro	IPR017948	Transforming growth factor beta, conserved site
InterPro	IPR001839	Transforming growth factor-beta, C-terminal
InterPro	IPR001111	Transforming growth factor-beta, N-terminal
InterPro	IPR015615	Transforming growth factor-beta-related
Protein Ontology	PR:000000184	TGF-beta 3

References

(Earliest) J:9636 Barton DE, et al., Chromosomal mapping of genes for transforming growth factors beta 2 and beta 3 in man and mouse: dispersion of TGF-beta gene family. Oncogene Res. 1988;3(4):323-31
(Latest) J:194131 Sugiyama D, et al., TGF-beta-1 up-regulates extra-cellular matrix production in mouse hepatoblasts. Mech Dev. 2013 Feb;130(2-3):195-206
All references(187)

Other accession IDs

MGD-MRK-15066, MGD-MRK-15069