Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Tbx3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes TBX3
- Mouse genes Tbx3
- Rat genes Tbx3
- Zfish genes tbx3a
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tbx3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	TBX3	IDA		Human	PMID:22130515
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Tbx3	IDA		Mouse	PMID:17473172
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	TBX3	IDA		Human	PMID:11689487
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	TBX3	IDA		Human	PMID:22130515
Molecular Function	GO:0005515	protein binding	TBX3	IPI	UniProtKB:P29590-4	Human	PMID:22002537
Molecular Function	GO:0005515	protein binding	TBX3	IPI	UniProtKB:P35219	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TBX3	IPI	UniProtKB:Q08117	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TBX3	IPI	UniProtKB:P86480	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX3	IPI	UniProtKB:Q6NVU6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX3	IPI	UniProtKB:Q8N4W3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TBX3	IPI	UniProtKB:Q99471	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Tbx3	IPI	UniProtKB:B7ZNG0	Mouse	PMID:27046536
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	TBX3	IDA		Human	PMID:11689487
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	TBX3	IDA		Human	PMID:12000749
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	TBX3	IDA		Human	PMID:22130515
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Tbx3	IDA		Mouse	MGI:MGI:5805984\|PMID:27720610
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Tbx3	IPI	UniProtKB:Q02591\|UniProtKB:Q9WUI0	Mouse	MGI:MGI:5448510\|PMID:22164283
Molecular Function	GO:0043565	sequence-specific DNA binding	TBX3	IDA		Human	PMID:11689487
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	TBX3	IDA		Human	PMID:28473536
Cellular Component	GO:0005929	cilium	Tbx3	IDA		Mouse	PMID:27046536
Cellular Component	GO:0005634	nucleus	TBX3	IDA		Human	PMID:11689487
Cellular Component	GO:0005634	nucleus	Tbx3	IDA		Mouse	PMID:19765559
Cellular Component	GO:0005634	nucleus	Tbx3	IDA		Mouse	PMID:18534921
Cellular Component	GO:0005634	nucleus	Tbx3	IDA		Mouse	PMID:18723448
Cellular Component	GO:0005667	transcription regulator complex	Tbx3	IPI	UniProtKB:Q5SSP7	Mouse	PMID:18285513
Biological Process	GO:0009887	animal organ morphogenesis	TBX3	IDA		Human	PMID:9207801
Biological Process	GO:0008595	anterior/posterior axis specification, embryo	TBX3	IMP		Human	PMID:9207801
Biological Process	GO:0003167	atrioventricular bundle cell differentiation	Tbx3	IMP	MGI:MGI:3710254	Mouse	PMID:18467625
Biological Process	GO:0036302	atrioventricular canal development	Tbx3	IGI	UniProtKB:Q60707	Mouse	MGI:MGI:5311550\|PMID:22130515
Biological Process	GO:1905222	atrioventricular canal morphogenesis	Tbx3	IGI	UniProtKB:Q60707	Mouse	MGI:MGI:5311550\|PMID:22130515
Biological Process	GO:0001568	blood vessel development	Tbx3	IMP	MGI:MGI:2655214	Mouse	PMID:12668638
Biological Process	GO:0060444	branching involved in mammary gland duct morphogenesis	Tbx3	IMP	MGI:MGI:2655214	Mouse	PMID:16222716
Biological Process	GO:0060317	cardiac epithelial to mesenchymal transition	TBX3	IMP		Human	PMID:22130515
Biological Process	GO:1905072	cardiac jelly development	TBX3	IMP		Human	PMID:22130515
Biological Process	GO:0055007	cardiac muscle cell differentiation	Tbx3	IMP	MGI:MGI:2655214	Mouse	PMID:17234970
Biological Process	GO:0060923	cardiac muscle cell fate commitment	Tbx3	IMP	MGI:MGI:3710254	Mouse	PMID:18467625
Biological Process	GO:0090398	cellular senescence	TBX3	IDA		Human	PMID:11748239
Biological Process	GO:0090398	cellular senescence	TBX3	IDA		Human	PMID:22002537
Biological Process	GO:0090398	cellular senescence	Tbx3	IDA		Mouse	PMID:11748239
Biological Process	GO:0006351	DNA-templated transcription	Tbx3	IMP	MGI:MGI:3710254	Mouse	PMID:17473172
Biological Process	GO:0042733	embryonic digit morphogenesis	TBX3	IMP		Human	PMID:12116211
Biological Process	GO:0042733	embryonic digit morphogenesis	TBX3	IMP		Human	PMID:9207801
Biological Process	GO:0042733	embryonic digit morphogenesis	Tbx3	IMP	MGI:MGI:5538564	Mouse	PMID:27046536
Biological Process	GO:0042733	embryonic digit morphogenesis	Tbx3	IMP	MGI:MGI:5538565	Mouse	PMID:23844108
Biological Process	GO:0035115	embryonic forelimb morphogenesis	TBX3	IMP		Human	PMID:12116211
Biological Process	GO:0035050	embryonic heart tube development	Tbx3	IMP	MGI:MGI:5538565	Mouse	PMID:23844108
Biological Process	GO:0035050	embryonic heart tube development	tbx3a	IMP	ZFIN:ZDB-MRPHLNO-080303-4	Zfish	PMID:17460765
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	Tbx3	IMP	MGI:MGI:5538565	Mouse	PMID:23844108
Biological Process	GO:0003272	endocardial cushion formation	TBX3	IMP		Human	PMID:22130515
Biological Process	GO:0030540	female genitalia development	TBX3	IMP		Human	PMID:12116211
Biological Process	GO:0046884	follicle-stimulating hormone secretion	TBX3	IMP		Human	PMID:12116211
Biological Process	GO:0035136	forelimb morphogenesis	TBX3	IDA		Human	PMID:9207801
Biological Process	GO:0001947	heart looping	Tbx3	IMP	MGI:MGI:2655214	Mouse	PMID:18723448
Biological Process	GO:0001947	heart looping	Tbx3	IMP	MGI:MGI:3769504	Mouse	PMID:17460765
Biological Process	GO:0003007	heart morphogenesis	Tbx3	IMP	MGI:MGI:3710254	Mouse	PMID:17473172
Biological Process	GO:0061017	hepatoblast differentiation	Tbx3	IMP	MGI:MGI:3769504	Mouse	PMID:18356246
Biological Process	GO:0001701	in utero embryonic development	Tbx3	IMP	MGI:MGI:3710254	Mouse	PMID:17473172
Biological Process	GO:0042472	inner ear morphogenesis	Tbx3	IGI	UniProtKB:Q60707	Mouse	MGI:MGI:6710296\|PMID:33795231
Biological Process	GO:0035108	limb morphogenesis	Tbx3	IMP	MGI:MGI:5538564	Mouse	PMID:27046536
Biological Process	GO:0035108	limb morphogenesis	Tbx3	IMP	MGI:MGI:2655214	Mouse	PMID:12668638
Biological Process	GO:0021761	limbic system development	Tbx3	IMP	MGI:MGI:3710254	Mouse	PMID:17473172
Biological Process	GO:0032275	luteinizing hormone secretion	TBX3	IMP		Human	PMID:12116211
Biological Process	GO:0030539	male genitalia development	TBX3	IMP		Human	PMID:12116211
Biological Process	GO:0030879	mammary gland development	TBX3	IMP		Human	PMID:12116211
Biological Process	GO:0030879	mammary gland development	Tbx3	IMP	MGI:MGI:2655214	Mouse	PMID:12668638
Biological Process	GO:0030879	mammary gland development	Tbx3	IMP	MGI:MGI:2655214	Mouse	PMID:16222716
Biological Process	GO:0030879	mammary gland development	Tbx3	IMP	MGI:MGI:3710254	Mouse	PMID:17473172
Biological Process	GO:0060596	mammary placode formation	Tbx3	IGI	MGI:MGI:98494	Mouse	PMID:16222716
Biological Process	GO:0060596	mammary placode formation	Tbx3	IDA		Mouse	PMID:17071745
Biological Process	GO:0048332	mesoderm morphogenesis	TBX3	IMP		Human	PMID:9207801
Biological Process	GO:0043066	negative regulation of apoptotic process	TBX3	IDA		Human	PMID:12032820
Biological Process	GO:0043066	negative regulation of apoptotic process	Tbx3	IMP		Rat	PMID:15694670\|RGD:1601420
Biological Process	GO:2000137	negative regulation of cell proliferation involved in heart morphogenesis	TBX3	IMP		Human	PMID:22130515
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	TBX3	IDA		Human	PMID:10468588
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	TBX3	IDA		Human	PMID:11689487
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Tbx3	IMP	MGI:MGI:3710254	Mouse	PMID:17473172
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Tbx3	IDA		Mouse	PMID:11748239
Biological Process	GO:0030857	negative regulation of epithelial cell differentiation	Tbx3	IMP	MGI:MGI:3769504	Mouse	PMID:18356246
Biological Process	GO:0045662	negative regulation of myoblast differentiation	TBX3	IDA		Human	PMID:12032820
Biological Process	GO:2000737	negative regulation of stem cell differentiation	Tbx3	IMP	MGI:MGI:3769504	Mouse	PMID:18356246
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	TBX3	IDA		Human	PMID:11689487
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	TBX3	IMP		Human	PMID:12000749
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	TBX3	IMP		Human	PMID:22130515
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Tbx3	IMP		Mouse	MGI:MGI:5805984\|PMID:27720610
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Tbx3	IMP		Rat	PMID:18285513\|RGD:8553896
Biological Process	GO:0003151	outflow tract morphogenesis	Tbx3	IMP	MGI:MGI:2655214	Mouse	PMID:18723448
Biological Process	GO:0045787	positive regulation of cell cycle	TBX3	IDA		Human	PMID:12032820
Biological Process	GO:0008284	positive regulation of cell population proliferation	TBX3	IDA		Human	PMID:12032820
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Tbx3	IMP	MGI:MGI:3710254	Mouse	PMID:17473172
Biological Process	GO:2000648	positive regulation of stem cell proliferation	Tbx3	IMP	MGI:MGI:3769504	Mouse	PMID:18356246
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	TBX3	IMP		Human	PMID:22130515
Biological Process	GO:0042127	regulation of cell population proliferation	Tbx3	IMP	MGI:MGI:3769504	Mouse	PMID:17460765
Biological Process	GO:0061635	regulation of protein complex stability	Tbx3	IMP	MGI:MGI:5538564	Mouse	PMID:27046536
Biological Process	GO:0031647	regulation of protein stability	Tbx3	IMP	MGI:MGI:5538564	Mouse	PMID:27046536
Biological Process	GO:0060021	roof of mouth development	Tbx3	IGI	MGI:MGI:98494	Mouse	PMID:19769959
Biological Process	GO:0048752	semicircular canal morphogenesis	Tbx3	IMP		Mouse	MGI:MGI:6710296\|PMID:33795231
Biological Process	GO:0060931	sinoatrial node cell development	TBX3	IDA		Human	PMID:22130515
Biological Process	GO:0060931	sinoatrial node cell development	Tbx3	IMP	MGI:MGI:3710254	Mouse	PMID:19096026
Biological Process	GO:0001501	skeletal system development	TBX3	IMP		Human	PMID:9207801
Biological Process	GO:0051145	smooth muscle cell differentiation	Tbx3	IGI	MGI:98494	Mouse	PMID:30478225
Biological Process	GO:0010159	specification of animal organ position	Tbx3	IDA		Mouse	PMID:17071745
Biological Process	GO:0019827	stem cell population maintenance	Tbx3	IMP	MGI:MGI:3769504	Mouse	PMID:18356246
Biological Process	GO:0072089	stem cell proliferation	Tbx3	IMP	MGI:MGI:3769504	Mouse	PMID:18356246
Biological Process	GO:0072105	ureteric peristalsis	Tbx3	IGI	MGI:98494	Mouse	PMID:30478225
Biological Process	GO:0060412	ventricular septum morphogenesis	Tbx3	IMP	MGI:MGI:3710254	Mouse	PMID:18467625

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.