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Gene Detail
T-box 3
Synonyms D5Ertd189e
Feature Type protein coding gene
Genetic Map
Chromosome 5
60.34 cM
Detailed Genetic Map ± 1 cM

Mapping data(5)
Sequence Map
Chr5:119670862-119684724 bp, + strand
From VEGA annotation of GRCm38

  13863 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:4371  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor Tbx2
Gene Tree: Tbx3

Human Homolog TBX3, T-box 3
NCBI Gene ID 6926
neXtProt AC  NX_O15119
Human Synonyms  TBX3-ISO, UMS, XHL
Human Chr (Location)  12q24.21; chr12:114670254-114684164 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TBX3
alleles, and
All mutations/alleles(28) : Gene trapped(19) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
Homozygous null mice die are embryonic lethal exhibiting defects in the yolk sac and limb defects. Female embryos show impaired mammary bud induction. Mice homozygous for hypomorphic alleles exhibit varying degrees of prenatal lethality and premature death, heart defects and limb abnormalities.
Human Diseases Modeled Using Mouse Tbx3 (1)    Alleles Annotated to Human Diseases(1)   
Tbx3 interacts with 225 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (61 annotations)
Process anterior/posterior axis specification, embryo, atrioventricular bundle cell differentiation, ...
Component nucleus, transcription factor complex
Function DNA binding, RNA polymerase II activating transcription factor binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Literature Summary: (103 records)
Data Summary: Results (468)    Tissues (250)    Images (105)
Theiler Stages: 2, 3, 4, 5, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 27, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 394
Northern blot 12
cDNA source data(23)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(32) cDNA(24) Primer pair(7) Other(1)
Microarray probesets(7)
Other database
VEGA Gene ModelOTTMUSG00000029655 (Evidence)
Ensembl Gene ModelENSMUSG00000018604 (Evidence)
Entrez Gene21386 (Evidence)
DFCITC1580848, TC1585487, TC1588645, TC1596166, TC1625873, TC1679694
DoTSDT.101272459, DT.101334916, DT.482666, DT.523086, DT.94122291
NIA Mouse Gene IndexU006096
Consensus CDS ProjectCCDS19613.1, CCDS19614.1
International Mouse Knockout Project StatusTbx3
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029655 VEGA Gene Model | MGI Sequence Detail 13863 C57BL/6J ±  kb
transcript OTTMUST00000073569 VEGA | MGI Sequence Detail 4856 Not Applicable 
polypeptide OTTMUSP00000038109 VEGA | MGI Sequence Detail 741 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(8) UniProt(8)
Polymorphisms SNPs within 2kb(62 from dbSNP Build 137)
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR002070 Transcription factor, Brachyury
InterPro IPR001699 Transcription factor, T-box
InterPro IPR018186 Transcription factor, T-box, conserved site
InterPro IPR022582 Transcription factor, T-box, region of unknown function
Protein Ontology PR:000016151 T-box transcription factor TBX3
References (Earliest) J:864 Namba T, et al., Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis. Biochem Biophys Res Commun. 1992 May 15;184(3):1197-203
(Latest) J:208341 Seth A, et al., Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
All references(153)
Disease annotation references (1)
accession IDs
MGD-MRK-14732, MGI:1098785

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory