Tbx3
Gene Detail

Symbol

Name
ID

Tbx3
T-box 3
MGI:98495

Synonyms

D5Ertd189e

Feature Type

protein coding gene

Genetic Map

Chromosome 5
60.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr5:119670862-119684724 bp, + strand From VEGA annotation of GRCm38   13863 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:4371  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor Tbx2
Gene Tree: Tbx3

Human
homologs

Human Homolog		TBX3, T-box 3
NCBI Gene ID		6926
neXtProt AC		NX_O15119
Human Synonyms		TBX3-ISO, UMS, XHL
Human Chr (Location)		12q24.21; chr12:114670254-114684164 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human TBX3

Mutations,
alleles, and
phenotypes

All mutations/alleles(28) : Gene trapped(19) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous null mice die are embryonic lethal exhibiting defects in the yolk sac and limb defects. Female embryos show impaired mammary bud induction. Mice homozygous for hypomorphic alleles exhibit varying degrees of prenatal lethality and premature death, heart defects and limb abnormalities.

 
Human Diseases Modeled in Mice Using Tbx3 (1)    Mutations Annotated to Human Diseases (1)   

Interactions

Tbx3 interacts with 225 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (68 annotations)

Process	anterior/posterior axis specification, embryo, atrioventricular bundle cell differentiation, ...
Component	nucleus, transcription factor complex
Function	DNA binding, RNA polymerase II activating transcription factor binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (112 records)

Data Summary: Results (508)    Tissues (279)    Images (128)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	3
RNA in situ	434
Northern blot	12
RT-PCR	59

cDNA source data(23)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(32) cDNA(24) Primer pair(7) Other(1)
Microarray probesets(7)

Other database
links

VEGA Gene Model	OTTMUSG00000029655 (Evidence)
Ensembl Gene Model	ENSMUSG00000018604 (Evidence)
Entrez Gene	21386 (Evidence)
DFCI	TC1580848, TC1585487, TC1588645, TC1596166, TC1625873, TC1679694
DoTS	DT.101272459, DT.101334916, DT.482666, DT.523086, DT.94122291
NIA Mouse Gene Index	U006096
Consensus CDS Project	CCDS19613.1, CCDS19614.1
International Mouse Knockout Project Status	Tbx3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029655	VEGA Gene Model | MGI Sequence Detail	13863	C57BL/6J
transcript	OTTMUST00000073569	VEGA | MGI Sequence Detail	4856	Not Applicable
polypeptide	OTTMUSP00000038109	VEGA | MGI Sequence Detail	741	Not Applicable

All sequences(75) RefSeq(8) UniProt(15)

Polymorphisms

SNPs within 2kb(62 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR002070	Transcription factor, Brachyury
InterPro	IPR001699	Transcription factor, T-box
InterPro	IPR018186	Transcription factor, T-box, conserved site
InterPro	IPR022582	Transcription factor, T-box, region of unknown function
Protein Ontology	PR:000016151	T-box transcription factor TBX3

References

(Earliest) J:864 Namba T, et al., Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis. Biochem Biophys Res Commun. 1992 May 15;184(3):1197-203
(Latest) J:214093 Cambier L, et al., Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. Development. 2014 Aug;141(15):2959-71
All references(161)
Disease annotation references (1)

Other
accession IDs

MGD-MRK-14732, MGI:1098785