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Tbx3
Gene Detail
Symbol

Name
ID
Tbx3
T-box 3
MGI:98495
Synonyms
D5Ertd189e
Feature Type
protein coding gene
Genetic Map
Chromosome 5
60.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:119670669-119684724 bp, + strand
From VEGA annotation of GRCm38

  14056 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4371  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TBX3
Protein SuperFamily: transcription factor Tbx2
Gene Tree: Tbx3

Human
homologs
TBX3, T-box 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6926
neXtProt AC: NX_O15119

Human Synonyms: TBX3-ISO, UMS, XHL

Human Chr (Location): 12q24.21; chr12:114670254-114684164 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TBX3

Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(19) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice die are embryonic lethal exhibiting defects in the yolk sac and limb defects. Female embryos show impaired mammary bud induction. Mice homozygous for hypomorphic alleles exhibit varying degrees of prenatal lethality and premature death, heart defects and limb abnormalities.
 
Human Diseases Modeled in Mice Using Tbx3 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Tbx3 interacts with 225 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Expression
Literature Summary: (115 records)
Data Summary: Results (516)    Tissues (282)    Images (133)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 437
Northern blot 12
RT-PCR 64
cDNA source data(23)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA TBX3 ; Xenbase tbx3 ; ZFIN tbx3a    NEW 
Molecular
reagents
All nucleic(33) cDNA(24) Primer pair(8) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000029655 (Evidence)
Ensembl Gene Model ENSMUSG00000018604 (Evidence)
Entrez Gene 21386 (Evidence)
DFCI TC1580848, TC1585487, TC1588645, TC1596166, TC1625873, TC1679694
DoTS DT.101272459, DT.101334916, DT.482666, DT.523086, DT.94122291
NIA Mouse Gene Index U006096
Consensus CDS Project CCDS19613.1, CCDS19614.1
International Mouse Phenotyping Consortium Status Tbx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029655 VEGA Gene Model | MGI Sequence Detail 14056 C57BL/6J ±  kb
transcript OTTMUST00000073569 VEGA | MGI Sequence Detail 4856 Not Applicable 
polypeptide OTTMUSP00000038109 VEGA | MGI Sequence Detail 741 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(6) UniProt(8)
Polymorphisms
SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR002070 Transcription factor, Brachyury
InterPro IPR001699 Transcription factor, T-box
InterPro IPR018186 Transcription factor, T-box, conserved site
InterPro IPR022582 Transcription factor, T-box, region of unknown function
Protein Ontology PR:000016151 T-box transcription factor TBX3
References
(Earliest) J:864 Namba T, et al., Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis. Biochem Biophys Res Commun. 1992 May 15;184(3):1197-203
(Latest) J:222440 Huang J, et al., Bmp4 from the optic vesicle specifies murine retina formation. Dev Biol. 2015 Jun 1;402(1):119-26
All references(162)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14732, MGI:1098785

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory