Tbx3
Gene Detail

Symbol Name ID

Tbx3 T-box 3 MGI:98495

Synonyms

D5Ertd189e

Feature Type

protein coding gene

Genetic Map

Chromosome 5

60.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr5:119670862-119684724 bp, + strand From VEGA annotation of GRCm38   13863 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4371  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transcription factor Tbx2
Gene Tree: Tbx3

Human homologs

Human Homolog		TBX3, T-box 3
NCBI Gene ID		6926
neXtProt AC		NX_O15119
Human Synonyms		TBX3-ISO, UMS, XHL
Human Chr (Location)		12q24.21; chr12:115108059-115121969 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TBX3

Alleles and phenotypes

All alleles(23) : Targeted(4) Gene trapped(19)
 

Homozygous null mice die are embryonic lethal exhibiting defects in the yolk sac and limb dysmorphology. Female embryos show impaired mammary bud induction.

 
Human Diseases Modeled Using Mouse Tbx3 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (61 annotations)

Process	anterior/posterior axis specification, embryo, atrioventricular bundle cell differentiation, ...
Component	nucleus, transcription factor complex
Function	DNA binding, RNA polymerase II activating transcription factor binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (94 records)
Data Summary: Results (471)    Tissues (245)    Images (104)
Theiler Stages: 2, 3, 4, 5, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	390
Northern blot	12
RT-PCR	66

cDNA source data(23)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(32) cDNA(24) Primer pair(7) Other(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000029655 (Evidence)
Ensembl Gene Model	ENSMUSG00000018604 (Evidence)
Entrez Gene	21386 (Evidence)
DFCI	TC1580848, TC1585487, TC1588645, TC1596166, TC1625873, TC1679694
DoTS	DT.101272459, DT.101334916, DT.482666, DT.523086, DT.94122291
NIA Mouse Gene Index	U006096
Consensus CDS Project	CCDS19613.1, CCDS19614.1
International Mouse Knockout Project Status	Tbx3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029655	VEGA Gene Model | MGI Sequence Detail	13863	C57BL/6J
transcript	OTTMUST00000073569	VEGA | MGI Sequence Detail	4856	Not Applicable
polypeptide	OTTMUSP00000038109	VEGA | MGI Sequence Detail	741	Not Applicable

All sequences(64) RefSeq(4) UniProt(8)

Polymorphisms

SNPs within 2kb(62 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR002070	Transcription factor, Brachyury
InterPro	IPR001699	Transcription factor, T-box
InterPro	IPR018186	Transcription factor, T-box, conserved site
InterPro	IPR022582	Transcription factor, T-box, region of unknown function
Protein Ontology	PR:000016151	T-box transcription factor TBX3

References

(Earliest) J:864 Namba T, et al., Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis. Biochem Biophys Res Commun. 1992 May 15;184(3):1197-203
(Latest) J:198684 Trowe MO, et al., Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis. Development. 2013 Jun;140(11):2299-309
All references(141)

Other accession IDs

MGD-MRK-14732, MGI:1098785